Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Laura A. Bruins"'
Autor:
Yuan Xiao Zhu, Laura A. Bruins, Xianfeng Chen, Chang‐Xin Shi, Cecilia Bonolo De Campos, Nathalie Meurice, Xuewei Wang, Greg J. Ahmann, Colleen A. Ramsower, Esteban Braggio, Lisa M. Rimsza, A. Keith Stewart
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 804-814 (2022)
Abstract Identifying biomarkers associated with disease progression and drug resistance are important for personalized care. We investigated the expression of 121 curated genes, related to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs
Externí odkaz:
https://doaj.org/article/8f3eb729be1e4a28ae8d99d742fc9bbd
Autor:
Cecilia Bonolo de Campos, Yuan Xiao Zhu, Nikolai Sepetov, Sergei Romanov, Laura Ann Bruins, Chang-Xin Shi, Caleb K. Stein, Joachim L. Petit, Alysia N. Polito, Meaghen E. Sharik, Erin W. Meermeier, Gregory J. Ahmann, Ilsel D. Lopez Armenta, Jonas Kruse, P. Leif Bergsagel, Marta Chesi, Nathalie Meurice, Esteban Braggio, A. Keith Stewart
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo
Externí odkaz:
https://doaj.org/article/36f9707664964168a6cc9caa0c85b080
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
The 31 most abundant of these sgRNAs found in cells surviving BTZ treatment were selected for secondary screening (Figure 2B). Each of the 31 potential BTZ resistance inducing genes was targeted by four sgRNAs, including three sgRNAs from the GeCKO V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e28fb5f94c566f66c12d1b4ddbeef22
https://doi.org/10.1158/1535-7163.22509895.v1
https://doi.org/10.1158/1535-7163.22509895.v1
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
We performed secondary screening in quadruplicate and next generation sequencing was again performed in the resistant cells. Sequencing results were listed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a420ba86562c631b721f38f7607bb7e
https://doi.org/10.1158/1535-7163.22509892
https://doi.org/10.1158/1535-7163.22509892
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
Figure legends for Figure S1 and S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e6d1cb0416b6bd323b9879c003290d
https://doi.org/10.1158/1535-7163.22509886
https://doi.org/10.1158/1535-7163.22509886
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
Bortezomib is highly effective in the treatment of multiple myeloma; however, emergent drug resistance is common. Consequently, we employed CRISPR targeting 19,052 human genes to identify unbiased targets that contribute to bortezomib resistance. Spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991771d07e189474207f72cdbc207bff
https://doi.org/10.1158/1535-7163.c.6539428
https://doi.org/10.1158/1535-7163.c.6539428
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
A&B. Cloned KMS11 cells with deleted PSMC6 had no difference for response against dexamethasone and melphalan. C. The 26S proteasome has no significant change in MM cells without PSMC6. D&E. Deficiency of PSMC1 to 5 had similar influence on sensitivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fea55ddb848237f78029dbda338044c
https://doi.org/10.1158/1535-7163.22509904
https://doi.org/10.1158/1535-7163.22509904
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
The mutation profile of all proteasome subunits in the genomic sequences derived by whole exome sequencing of 895 patients in the IA10 release of the CoMMpass study (https://www.themmrf.org/). A total of 36 mutations in 19S proteasome subunits were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c70080769bd0bda2a92681c4d369c8
https://doi.org/10.1158/1535-7163.22509889
https://doi.org/10.1158/1535-7163.22509889
Autor:
A. Keith Stewart, Esteban Braggio, William Stewart, Cecilia Bonolo de Campos, Laura A. Bruins, Yuan Xiao Zhu, Chang-Xin Shi
Sup.Fig.1. Expression of PSMB5 and PSMB6 from BTZ resistant MM cell lines JJN3, My5, and U266. Sup.Fig.2. Expression of PSMB5 detected by native and denaturing gels from cloned RPMI-8226 cells knocking out PSMB5. Sup.Fig.3. Selection of high efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749f99e2af3cd7df99e5c953b128e7ab
https://doi.org/10.1158/1541-7786.22514245.v1
https://doi.org/10.1158/1541-7786.22514245.v1
Autor:
A. Keith Stewart, Esteban Braggio, Jonathan Ahmann, Robert A. Stewart, Moulun Luo, Patrick G. Votruba, Patrick Jedlowski, Laura A. Bruins, Yuan Xiao Zhu, K. Martin Kortüm, Chang-Xin Shi
A. Cloned RPMI8226 cells with deleted PSMC6 also developed resistance to carfilzomib.B&C. Cloned KMS11 cells with deleted PSMC6 developed resistance to BTZ.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b360af2e8b15c2df29be865bd2e320
https://doi.org/10.1158/1535-7163.22509907
https://doi.org/10.1158/1535-7163.22509907