Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2

Autor: Lindsey A. Starr, Luke E. McKay, Kylie N. Peter, Lena M. Seyfarth, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell

Publikováno v: Journal of Developmental Biology, Vol 11, Iss 2, p 20 (2023)

Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicated in several neurological disorders, including Parkinson’s disease (PD). Here, we report results of a RNAi screen of genes differentially regulated in adr-2

Externí odkaz: https://doaj.org/article/be6053b767b94eafa7808a5b6b9b9fa6

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.

Autor: Anthony L Gaeta, J Brucker Nourse, Karolina Willicott, Luke E McKay, Candice M Keogh, Kylie Peter, Shannon N Russell, Shusei Hamamichi, Laura A Berkowitz, Kim A Caldwell, Guy A Caldwell

Publikováno v: PLoS Genetics, Vol 18, Iss 8, p e1010115 (2022)

The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to both internal and external factors have i

Externí odkaz: https://doaj.org/article/53708f6cb73f44008e3c22599f1098fc

Prenatal alcohol exposure disrupts hippocampal sharp-wave ripple-associated spike dynamics

Autor: Ryan E. Harvey, Benjamin J. Clark, Daniel D. Savage, Laura E. Berkowitz

Prenatal alcohol exposure (PAE) is among the most common developmental insults to the nervous system and is characterized by memory disruption. There is a pressing need to identify physiological alterations that help explain this memory impairment. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cc60725cc2ac1b2ab0b8e196a375704
https://doi.org/10.1101/2021.06.29.450435

Altered Hippocampal Place Cell Representation and Theta Rhythmicity following Moderate Prenatal Alcohol Exposure

Autor: Benjamin J. Clark, Ryan E. Harvey, Derek A. Hamilton, Daniel D. Savage, Laura E. Berkowitz

Publikováno v: Curr Biol

SummaryPrenatal alcohol exposure (PAE) leads to profound deficits in spatial memory and synaptic and cellular alterations to the hippocampus that last into adulthood. Neurons in the hippocampus, called place cells, discharge as an animal enters speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca51599bf0698c76a8099031d92b941b
https://pubmed.ncbi.nlm.nih.gov/32961165

Contributors

Autor: Albert Aboseif, Morandi Alessandro, Carolina Alquézar, Rachel Anderson, Ellika Andolf, Tatiana Andreeva, Yasuhisa Ano, Yuko Araki, Eva M. Arroyo-Anlló, Tatsuhiro Ayabe, Mi Ae Bae, Kelly M. Bakulski, Vladimir J. Balcar, Vito Antonio Baldassarro, Petronilla Battista, Antonello Bellomo, Małgorzata Bednarska-Makaruk, Tammie L. Benzinger, Laura E. Berkowitz, L.C. Berumen, Andrea Bighinati, Amy Brodtmann, Josiane Budni, Laura Calzà, Rosa Capozzo, Paulo Caramelli, Barbara R. Cardoso, Jessie S. Carr, Javier Carrasco, J.W. Chang, Kyung Ja Chang, Lu Hua Chen, Sheung-Tak Cheng, Pozzi Christian, Leung Wing Chu, G. Cipriani, Benjamin J. Clark, Gemma Comes, Fabio Coppedè, Mar Cuadrado-Tejedor, Emanuela D'Acunto, Antonio Daniele, S. Danti, Antonella De Jaco, Rafael de la Torre, M. Di Fiorino, Grossi Eleonora, Kristina Endres, Anna Escrig, Robert V. Farese, Olaya Fernández-Gayol, Vitaly Fokin, Dan Frenkel, Wen Fu, Giovanna Galliciotti, G. García-Alcocer, Ana Garcia-Osta, Luciana Giardino, Roger Gil, Mercedes Giralt, Bellelli Giuseppe, Karina Braga Gomes, Manuel Gonçalves-Pereira, Miriam González-Gómez, Nandu Goswami, Elie Gottlieb, Antonio Greco, Dorothy M. Grillo, Natalie A. Grima, Chiara Griseta, Malena dos Santos Guilherme, Ryan E. Harvey, Manabu Hashimoto, Nathan Herrmann, Adriana Gisele Hertzog da Silva Leme, Emi Hibino, Juan Hidalgo, Mark Howard, Howard Hu, Sergey Illarioshkin, Nibaldo C. Inestrosa, Jack H. Jhamandas, Amber Khan, Maddalena La Montagna, Krista L. Lanctôt, Katarzyna Laskowska-Kaszub, Han-Kyu Lee, Lei Liu, Celina S. Liu, Alberto Llorente-Ovejero, Giancarlo Logroscino, Laura Lombardero, Stephanie Lozano, Madia Lozupone, Yasmina Manso, Iván Manuel, Raquel Marin, Ángeles Martín-Requero, Pamela V. Martino Adami, J. Mendiola-Precoma, Elena Miranda, Yachiyo Mitsuishi, Amalia Molinero, Laura Morelli, John C. Morris, Kelsey E. Murphy, Masaki Nakano, Siranjeevi Nagaraj, Yuval Nash, Masaki Nishimura, A. Nuti, Jade de Oliveira, Francesco Panza, Joshua J. Park, Y.S. Park, Sung Kyun Park, Matthew P. Pase, L. Picchi, Natalya Ponomareva, Matthew L. Poole, Victor R. Preedy, Ricardo Puertas-Avendaño, Henry Querfurth, David Quinto-Alemany, Luís Felipe José Ravic de Miranda, Rajkumar Rajendram, Onofrio Resta, Sven Reinhardt, A. Rodríguez-Cruz, Rafael Rodríguez-Puertas, Evgeny Rogaev, Michael Rosen, Mini P. Sajan, Paula Sanchis, Michele Sannia, Rodolfo Sardone, Makoto Sasaki, Diego Sepulveda-Falla, Davide Seripa, Omar Šerý, Daniel W. Sirkis, You-Qiang Song, Brenda Bin Su, Takuma Sugi, Paulina Villaseca, Adam P. Vogel, Douglas Gordon Walker, Hoau-Yan Wang, Kesheng Wang, Naoki Watanabe, David Weidman, Urszula Wojda, Benjamin K.P. Woo, Laura Xicota, Chun Xu, Dmitriy A. Yablonskiy, Fumio Yamashita, Hiroshi Yao, Jennifer S. Yokoyama, Fan Zhang, Juan M. Zolezzi, Katarzyn Marta Zoltowska

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9819dd54c387482eb5064a8816c26d6b
https://doi.org/10.1016/b978-0-12-815868-5.01002-1