Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Laura A. A. Gilliam"'
Autor:
Terence E. Ryan, Cody D. Smith, Lauren Reese, Deborah M. Muoio, Brook L. Cathey, Chien-Te Lin, Kelsey H. Fisher-Wellman, Daniel S. Lark, P. Darrell Neufer, Laura A. A. Gilliam
Publikováno v:
Biochemical Journal. 467:271-280
Cellular proteins rely on reversible redox reactions to establish and maintain biological structure and function. How redox catabolic (NAD+:NADH) and anabolic (NADP+:NADPH) processes integrate during metabolism to maintain cellular redox homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc828d47e95aecace2f62a8dfc4cf709
https://doi.org/10.1042/bj20141447
https://doi.org/10.1042/bj20141447
Autor:
Chien-Te Lin, Brook L. Cathey, P. Darrell Neufer, Kelsey H. Fisher-Wellman, Laura A. A. Gilliam, Daniel S. Lark
Publikováno v:
Free Radical Biology and Medicine. 65:1201-1208
Once regarded as a "by-product" of aerobic metabolism, the production of superoxide/H2O2 is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of thiol-containing proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e60ae0b58d0e9950955c0839b990c8e
https://doi.org/10.1016/j.freeradbiomed.2013.09.008
https://doi.org/10.1016/j.freeradbiomed.2013.09.008
Autor:
Laura A. A. Gilliam, P. Darrell Neufer, Jill M. Maples, Chien-Te Lin, Kelsey H. Fisher-Wellman, Brook L. Cathey
Publikováno v:
Free Radical Biology and Medicine. 65:988-996
The combined loss of muscle strength and constant fatigue are disabling symptoms for cancer patients undergoing chemotherapy. Doxorubicin, a standard chemotherapy drug used in the clinic, causes skeletal muscle dysfunction and premature fatigue along
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e781ee22d7b47bab7e7746bb38dca5da
https://doi.org/10.1016/j.freeradbiomed.2013.08.191
https://doi.org/10.1016/j.freeradbiomed.2013.08.191
Autor:
Chang Yu, Laura A. A. Gilliam, Matthew T. Bojanowski, Nancy J. Brown, T. Alp Ikizler, L. Jackson Roberts, Jonathan Himmelfarb, Baback Roshanravan, Jorge L. Gamboa, Frederic T. Billings
Publikováno v:
Physiological reports, vol 4, iss 9
Physiological Reports
Physiological Reports
Mitochondria abnormalities in skeletal muscle may contribute to frailty and sarcopenia, commonly present in patients with chronic kidney disease (CKD). Dysfunctional mitochondria are also a major source of oxidative stress and may contribute to cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79131f84e9e73da223ddb4cf4aefd08a
https://escholarship.org/uc/item/3b0845c1
https://escholarship.org/uc/item/3b0845c1
Autor:
Laura A. A. Gilliam, P. Darrell Neufer
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:631-636
The prevalence and economic burden of obesity and type 2 diabetes is a driving force for the discovery of molecular targets to improve insulin sensitivity and glycemic control. Here, we review several transgenic mouse models that identify promising t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31e84b161a95cb512834b535a13b58c7
https://doi.org/10.1124/jpet.112.192146
https://doi.org/10.1124/jpet.112.192146
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 300:L225-L231
Doxorubicin, a common chemotherapeutic agent, causes respiratory muscle weakness in both patients and rodents. Tumor necrosis factor-α (TNF), a proinflammatory cytokine that depresses diaphragm force, is elevated following doxorubicin chemotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370f6f2dba980ca9220a7bcc8d517e40
https://doi.org/10.1152/ajplung.00264.2010
https://doi.org/10.1152/ajplung.00264.2010
Autor:
Laura A. A. Gilliam, Jennifer S. Moylan, Michael B. Reid, Leigh Ann Callahan, Marius P. Sumandea
Publikováno v:
Muscle & Nerve. 43:94-102
Doxorubicin is a chemotherapeutic agent prescribed for a variety of tumors. While undergoing treatment, patients exhibit frequent symptoms that suggest respiratory muscle weakness. Cancer patients can receive doxorubicin chemotherapy through either i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca600cd393e65808b49d64bc811ae9eb
https://doi.org/10.1002/mus.21809
https://doi.org/10.1002/mus.21809
Autor:
Michael B. Reid, Mariana Nikolova-Karakashian, Jennifer S. Moylan, Leonardo F. Ferreira, Laura A. A. Gilliam, Jeffrey D. Smith
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C552-C560
Sphingomyelinase (SMase) hydrolyzes membrane sphingomyelin into ceramide, which increases oxidants in nonmuscle cells. Serum SMase activity is elevated in sepsis and heart failure, conditions where muscle oxidants are increased, maximal muscle force
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd85ea3f25a21f119ee214ff4b082401
https://doi.org/10.1152/ajpcell.00065.2010
https://doi.org/10.1152/ajpcell.00065.2010
Autor:
Cheryl A.S. Smith, Terence E. Ryan, Katherine A. Buddo, Sira Karvinen, Kimberly A. Kew, Tonya N. Zeczycki, Dawn A. Lowe, P. Darrell Neufer, Saame Raza Shaikh, Espen E. Spangenburg, Maria J. Torres, Laura A. A. Gilliam, Edward Ross Pennington, Amy Fix, Chien Te Lin
Publikováno v:
Cell Metabolism. 27:167-179.e7
Summary Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72eb34f10a25f1ffbe1047ac36b53289
https://doi.org/10.1016/j.cmet.2017.10.003
https://doi.org/10.1016/j.cmet.2017.10.003
Autor:
Lauren Reese, P. Darrell Neufer, Maria J. Torres, Laura A. A. Gilliam, Terence E. Ryan, Daniel S. Lark, Chien-Te Lin, Brook L. Cathey
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 311(2)
The loss of strength in combination with constant fatigue is a burden on cancer patients undergoing chemotherapy. Doxorubicin, a standard chemotherapy drug used in the clinic, causes skeletal muscle dysfunction and increases mitochondrial H2O2. We hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6bf2f923e516e06041d1f2e9930086
https://pubmed.ncbi.nlm.nih.gov/27329802
https://pubmed.ncbi.nlm.nih.gov/27329802