Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Laura A Horky"'
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Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system
Autor: Rachel Pauplis, Jack Hoppin, Leighla Tayefeh, Laura L. Horky, Ajay Verma, Eric E. Swayze, Daniel A. Wolf, Curt Mazur, Jacob Hesterman, Bethany Fitzsimmons, Jenna M. Sullivan, Holly Kordasiewicz, Scott Haller, Berit Powers, Bea DeBrosse-Serra, Nicolas Currier
Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Background The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospinal fluid as a means for incr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2263e541ba13dba6694b316d5b473a3f
https://doi.org/10.1186/s12967-020-02461-2
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2
Convective forces increase rostral delivery of intrathecal antisense oligonucleotides in the cynomolgus monkey nervous system
Autor: Daniel A. Wolf, Curt Mazur, Jacob Hesterman, Scott Haller, Leighla Tayefeh, Laura L. Horky, Ajay Verma, Holly B. Kordasiewicz, Bea DeBrosse-Serra, Jenna M. Sullivan, Eric E. Swayze, Rachel Pauplis, Bethany Fitzsimmons, Nicolas Currier, Jack Hoppin, Berit Powers
BackgroundThe intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood-brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospinal fluid as a means for increas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b2e5a4895597d2bb9f9e4f2d81f902
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3
Intrathecal 99mTc‐DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans
Autor: Laura L. Horky, Jacob Hesterman, Shankar Vallabhajosula, J. Levi Chazen, Patrick Connolly, Ajay Verma, Robert W. Holt, P. David Mozley
Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Introduction Cerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches. Methods Following intrathecal (ITH) dosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71502c39ee7fc0b7a1e122fda9412bb7
https://doaj.org/article/26b1d90e44cc4558819baad9e560f199
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4
Akademický článek
Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection.
Autor: Sandrine Thuret, Michaela Thallmair, Laura L Horky, Fred H Gage
Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30904 (2012)
Adult MRL/MpJ mice have been shown to possess unique regeneration capabilities. They are able to heal an ear-punched hole or an injured heart with normal tissue architecture and without scar formation. Here we present functional and histological evid
Externí odkaz: https://doaj.org/article/cb3d2eb538934a83bf45ba51013abae5
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5
Automated segmentation of MR imaging to determine normative central nervous system cerebrospinal fluid volumes in healthy volunteers
Autor: Ajay Verma, Jonathan P. Dyke, Rachel Pauplis, J. Levi Chazen, David P. Mozley, Jacob Hesterman, Laura L. Horky, Robert W. Holt
Publikováno v: Clinical Imaging. 43:132-135
An accurate non-invasive method to determine total body cerebrospinal fluid volume has a number of potential diagnostic and therapeutic applications. Herein we describe a technique for automated segmentation of total body MRI data to determine crania
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e519a1b3d43830dc17ac209595f7ad45
https://doi.org/10.1016/j.clinimag.2017.02.007
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7
Introduction of a novel ultrahigh sensitivity collimator for brain SPECT imaging
Autor: Marie Foley Kijewski, Laura L. Horky, Morgan C. Lyon, Mark Keijzers, Mi-Ae Park, Ronnie Keijzers, Stephen C. Moore
Publikováno v: Medical Physics. 43:4734-4741
Purpose Noise levels of brain SPECT images are highest in central regions, due to preferential attenuation of photons emitted from deep structures. To address this problem, the authors have designed a novel collimator for brain SPECT imaging that yie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e54e849cdf021024fca5c7df610929ef
https://doi.org/10.1118/1.4958962
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8
Systemic chemotherapy decreases brain glucose metabolism
Autor: Usha Govindarajulu, Jon Hainer, Jorg Dietrich, Wen Plesniak, Victor H. Gerbaudo, Alexander Zaitsev, Ron Kikinis, Laura L. Horky
Publikováno v: Annals of Clinical and Translational Neurology
Objective Cancer patients may experience neurologic adverse effects, such as alterations in neurocognitive function, as a consequence of chemotherapy. The mechanisms underlying such neurotoxic syndromes remain poorly understood. We here describe the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594c6ac07f7ae548d53e2528ac265d78
http://europepmc.org/articles/PMC4241806
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9
PET and SPECT in Brain Tumors and Epilepsy
Autor: S. Ted Treves, Laura L. Horky
Publikováno v: Neurosurgery Clinics of North America. 22:169-184
Molecular imaging with positron emission tomography (PET) plays an important role in the diagnosis and management of patients with brain tumors and epilepsy. The clinical uses of FDG are discussed, as well as the research applications of novel PET tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6386ef9195f99abbaecba948adba0d9
https://doi.org/10.1016/j.nec.2010.12.003
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