Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Laura A, Novotny"'
Autor:
Sharon L. Clark, Elke J. Seppanen, Lea-Ann S. Kirkham, Laura A. Novotny, Lauren O. Bakaletz, Allan W. Cripps, Karli Corscadden, Harvey Coates, Shyan Vijayasekaran, Peter C. Richmond, Ruth B. Thornton
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundNontypeable Haemophilus influenzae (NTHi) is the most common bacterial otopathogen associated with otitis media (OM). NTHi persists in biofilms within the middle ears of children with chronic and recurrent OM. Australian Aboriginal children
Externí odkaz:
https://doaj.org/article/0645a21149bd43f695372d7de5aeb56c
Publikováno v:
Viruses, Vol 15, Iss 3, p 632 (2023)
Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple IFNLR1 transcriptional variants are expresse
Externí odkaz:
https://doaj.org/article/9b436df997264991bc46d5acd6022f55
Autor:
Elaine M. Mokrzan, Christian P. Ahearn, John R. Buzzo, Laura A. Novotny, Yan Zhang, Steven D. Goodman, Lauren O. Bakaletz
Publikováno v:
Biofilm, Vol 2, Iss , Pp 100039- (2020)
Biofilms contribute significantly to the chronicity and recurrence of bacterial diseases due to the fact that biofilm-resident bacteria are highly recalcitrant to killing by host immune effectors and antibiotics. Thus, antibody-mediated release of ba
Externí odkaz:
https://doaj.org/article/8885ebc905474210b15edbadf47195f7
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Nontypeable Haemophilus influenzae (NTHI) colonizes the human nasopharynx, but when the host immune response is dysregulated by upper respiratory tract (URT) virus infection, NTHI can gain access to more distal airway sites and cause disease
Externí odkaz:
https://doaj.org/article/e4acfb9464504da5bc4f035404f9393e
Autor:
Michael T. Bailey, Christian L. Lauber, Laura A. Novotny, Steven D. Goodman, Lauren O. Bakaletz
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT The use of broad-spectrum antibiotics to treat diseases, such as the highly prevalent pediatric disease otitis media (OM), contributes significantly to the worldwide emergence of multiple-antibiotic-resistant microbes, and gut dysbiosis with
Externí odkaz:
https://doaj.org/article/e70183c32d80473da1288610809dabc9
Publikováno v:
Viruses, Vol 13, Iss 6, p 1090 (2021)
Hepatitis B virus (HBV) chronically infects over 250 million people worldwide and causes nearly 1 million deaths per year due to cirrhosis and liver cancer. Approved treatments for chronic infection include injectable type-I interferons and nucleos(t
Externí odkaz:
https://doaj.org/article/dc5b4a328be14519af80ca25970a028e
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 33-44 (2016)
The vast majority of chronic and recurrent bacterial diseases are attributed to the presence of a recalcitrant biofilm that contributes significantly to pathogenesis. As such, these diseases will require an innovative therapeutic approach. We targete
Externí odkaz:
https://doaj.org/article/2af1921ab12945508ff610ed6c1d2c01
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Otitis media (OM) is often polymicrobial, with nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis (Mcat) frequently cocultured from clinical specimens. Bacterial biofilms in the middle ear contribute to the chronicity and re
Externí odkaz:
https://doaj.org/article/6f786e962b5a49f2955a55512c060fa9
Autor:
Sharon L, Clark, Elke J, Seppanen, Lea-Ann S, Kirkham, Laura A, Novotny, Lauren O, Bakaletz, Allan W, Cripps, Karli, Corscadden, Harvey, Coates, Shyan, Vijayasekaran, Peter C, Richmond, Ruth B, Thornton
Publikováno v:
Frontiers in cellular and infection microbiology. 12
NontypeableAn in-house multiplex fluorescent bead immunoassay was used to measure serum IgG titres and avidity for three putative vaccine antigens: recombinant soluble PilA (rsPilA), ChimV4, and outer membrane protein 26 (OMP26) in sera from Australi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c071372ab49a5c4ca7a6664eebbe79d0
https://pubmed.ncbi.nlm.nih.gov/35463651
https://pubmed.ncbi.nlm.nih.gov/35463651
Autor:
John R. Buzzo, Steven D. Goodman, Frank Robledo-Avila, Lauren Mashburn-Warren, Lauren O. Bakaletz, Aishwarya Devaraj, Santiago Partida-Sanchez, Joseph A. Jurcisek, Natalia O. Tjokro, Laura A. Novotny
Publikováno v:
J Clin Invest
Herein, we describe an extracellular function of the vertebrate high-mobility group box 1 protein (HMGB1) in the proliferation of bacterial biofilms. Within host cells, HMGB1 functions as a DNA architectural protein, similar to the ubiquitous DNABII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0498f5bf3939a54402bd5a909de32b
https://doi.org/10.1172/jci140527
https://doi.org/10.1172/jci140527