Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics

Autor: Christopher Campbell, Claire Fingleton, Merve S. Zeden, Emilio Bueno, Laura A. Gallagher, Dhananjay Shinde, Jongsam Ahn, Heather M. Olson, Thomas L. Fillmore, Joshua N. Adkins, Fareha Razvi, Kenneth W. Bayles, Paul D. Fey, Vinai C. Thomas, Felipe Cava, Geremy C. Clair, James P. O’Gara

Publikováno v: mBio, Vol 12, Iss 3 (2021)

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Externí odkaz: https://doaj.org/article/e4f0ec57fff44791bcf41bfd3a0e63ec

Habitat selection of the Mauritian lowland forest day gecko at multiple spatial scales: A baseline for translocation

Autor: Steeves Buckland, Nik C. Cole, Ben Godsall, Javier Rodríguez-Pérez, Laura E. Gallagher, Sion M. Henshaw, Stephen Harris

Publikováno v: Global Ecology and Conservation, Vol 1, Iss C, Pp 71-79 (2014)

Of 30 known subpopulations of Phelsuma guimbeaui, 18 are in patches of exotic forest and are predicted to disappear in the next decade. One possible means of mitigating the reduction in genetic diversity associated with the loss of subpopulations is

Externí odkaz: https://doaj.org/article/fa597d0625aa4c24bfdafc9281bba4a7

High risks of losing genetic diversity in an endemic Mauritian gecko: implications for conservation.

Autor: Steeves Buckland, Nik C Cole, Jim J Groombridge, Clemens Küpper, Terry Burke, Deborah A Dawson, Laura E Gallagher, Stephen Harris

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e93387 (2014)

Genetic structure can be a consequence of recent population fragmentation and isolation, or a remnant of historical localised adaptation. This poses a challenge for conservationists since misinterpreting patterns of genetic structure may lead to inap

Externí odkaz: https://doaj.org/article/6eb33aa8feb94d238e145e62dc38c4eb

The novel membrane-associated auxiliary factors auxA and auxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids

Autor: Jeremy P. Derrick, Laura A. Gallagher, Katrine Nøhr-Meldgaard, Guoqing Xia, Martin Vestergaard, James P. O'Gara, Andrew J. McBain, Waldemar Vollmer, Katharina Mayer, Tom Grunert, Ohood Alharbi, Huayong Liu, Mohanned Alharbi, Jacob Biboy, Wanchat Sirisarn, Hanne Ingmer, Kasper Mikkelsen

Publikováno v: Mikkelsen, K, Sirisarn, W, Alharbi, O, Alharbi, M, Liu, H, Nøhr-Meldgaard, K, Mayer, K, Vestergaard, M, Gallagher, L, Derrick, J, Mcbain, A, Biboy, J, Vollmer, W, O'Gara, J, Grunert, T, Ingmer, H & Xia, G 2021, ' The novel membrane-associated auxiliary factors auxA and auxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids ', International Journal of Antimicrobial Agents, vol. 57, no. 3, 106283 . https://doi.org/10.1016/j.ijantimicag.2021.106283
Mikkelsen, K, Sirisarn, W, Alharbi, O, Alharbi, M, Liu, H, Nøhr-Meldgaard, K, Mayer, K, Vestergaard, M, Gallagher, L A, Derrick, J P, McBain, A J, Biboy, J, Vollmer, W, O'Gara, J P, Grunert, T, Ingmer, H & Xia, G 2021, ' The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate β-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids ', International Journal of Antimicrobial Agents, vol. 57, no. 3, 106283 . https://doi.org/10.1016/j.ijantimicag.2021.106283

A major determinant of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) is the drug insensitive transpeptidase, PBP2a, encoded by mecA. Full expression of the resistance phenotype requires auxiliary factors. Two such factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be9c69b4caa8e9988eb1879d3d32b07
https://doi.org/10.1016/j.ijantimicag.2021.106283

Advances in Autophagy Regulatory Mechanisms

Autor: Laura E. Gallagher, Leon E. Williamson, Edmond Y. W. Chan

Publikováno v: Cells, Vol 5, Iss 2, p 24 (2016)

Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagoso

Externí odkaz: https://doaj.org/article/a3212997720e4250a380417f39dca289