Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Laura Sturla"'
Autor:
Sonia Spinelli, Lucrezia Guida, Mario Passalacqua, Mirko Magnone, Bujar Caushi, Elena Zocchi, Laura Sturla
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 2071 (2024)
Rat H9c2 cardiomyocytes overexpressing the abscisic acid (ABA) hormone receptors LANCL1 and LANCL2 have an increased mitochondrial proton gradient, respiration, and vitality after hypoxia/reoxygenation. Our aim was to investigate the role of the ABA/
Externí odkaz:
https://doaj.org/article/14cc1bd3a110460d9fa599201526cf2e
Autor:
Andrea Benzi, Markus Heine, Sonia Spinelli, Annalisa Salis, Anna Worthmann, Björn Diercks, Cecilia Astigiano, Raúl Pérez Mato, Adela Memushaj, Laura Sturla, Valerio Vellone, Gianluca Damonte, Michelle Y. Jaeckstein, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionDuring thermogenesis, adipose tissue (AT) becomes more active and enhances oxidative metabolism. The promotion of this process in white AT (WAT) is called “browning” and, together with the brown AT (BAT) activation, is considered as a
Externí odkaz:
https://doaj.org/article/6cbc007a0f474be38c4530fd56e6e433
Autor:
Sonia Spinelli, Maurizio Bruschi, Mario Passalacqua, Lucrezia Guida, Mirko Magnone, Laura Sturla, Elena Zocchi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4796 (2024)
The orphan nuclear receptor ERRα is the most extensively researched member of the estrogen-related receptor family and holds a pivotal role in various functions associated with energy metabolism, especially in tissues characterized by high energy re
Externí odkaz:
https://doaj.org/article/1a9ddca85eec464c8737d68de2104972
Autor:
Elena Abbotto, Caterina Miro, Francesco Piacente, Annalisa Salis, Melania Murolo, Annarita Nappi, Enrico Millo, Eleonora Russo, Elena Cichero, Laura Sturla, Alberto Del Rio, Antonio De Flora, Alessio Nencioni, Monica Dentice, Santina Bruzzone
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115326- (2023)
Sirtuin 6 (SIRT6) has a critical role in cutaneous Squamous Cell Carcinoma (cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion abrogated DMBA-TPA-induced skin tumorigenesis in mice. On the other hand, SIRT6 ac
Externí odkaz:
https://doaj.org/article/487ea97481c846938c17d04b08a92400
Autor:
Naomi Scarano, Francesco Di Palma, Nicola Origlia, Francesca Musumeci, Silvia Schenone, Sonia Spinelli, Mario Passalacqua, Elena Zocchi, Laura Sturla, Elena Cichero, Andrea Cavalli
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2754 (2023)
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits glutathionylation activity and is involved in the neutralization of reactive electrop
Externí odkaz:
https://doaj.org/article/abc95c220691413f81e9bfd0dbc7cf75
Autor:
Elena Abbotto, Beatrice Casini, Francesco Piacente, Naomi Scarano, Elena Cerri, Michele Tonelli, Cecilia Astigiano, Enrico Millo, Laura Sturla, Santina Bruzzone, Elena Cichero
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1316 (2023)
Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining attention for the treatment of different cancer types, but also to contrast neurodegenerative disease, diabetes, and autoimmune syndromes. In the search for SIRT
Externí odkaz:
https://doaj.org/article/46865828e47740e4bb165765d251573f
Autor:
Sonia Spinelli, Lucrezia Guida, Mario Passalacqua, Mirko Magnone, Vanessa Cossu, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1692 (2023)
The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO generation. The overexpression of LANCL1/2 increases transcription, phosphorylation
Externí odkaz:
https://doaj.org/article/4dc2e87cc10b4478ab8cb3949999c275
Autor:
Giovanni Ferrara, Andrea Benzi, Laura Sturla, Daniela Marubbi, Davide Frumento, Sonia Spinelli, Elena Abbotto, Federico Ivaldi, Maria von Holtey, Maximilien Murone, Alessio Nencioni, Antonio Uccelli, Santina Bruzzone
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of multiple sclerosis (MS), a neuroinflammatory and demyelinating disease characterized by multifocal perivascular infiltrates of immune cells. Althou
Externí odkaz:
https://doaj.org/article/4deab08ee3b44bc9953257badeeaa843
Autor:
Sonia Spinelli, Vanessa Cossu, Mario Passalacqua, Jacob B. Hansen, Lucrezia Guida, Mirko Magnone, Gianmario Sambuceti, Cecilia Marini, Laura Sturla, Elena Zocchi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3489 (2023)
The abscisic acid (ABA)/LANC-like protein 1/2 (LANCL1/2) hormone/receptor system regulates glucose uptake and oxidation, mitochondrial respiration, and proton gradient dissipation in myocytes. Oral ABA increases glucose uptake and the transcription o
Externí odkaz:
https://doaj.org/article/c90cfe03d4cf4eb38e070bbc6165fb9d
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1199 (2023)
Abscisic acid (ABA), long known as a plant stress hormone, is present and functionally active in organisms other than those pertaining to the land plant kingdom, including cyanobacteria, fungi, algae, protozoan parasites, lower Metazoa, and mammals.
Externí odkaz:
https://doaj.org/article/34b05a7e3b574282b2189777223009ef