Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Laura Stertz"'
Autor:
Thiago Wendt Viola, Christina Danzer, Victor Mardini, Claudia Szobot, João Henrique Chrusciel, Laura Stertz, Joy M. Schmitz, Consuelo Walss-Bass, Gabriel R. Fries, Rodrigo Grassi-Oliveira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB
Externí odkaz:
https://doaj.org/article/c7d1593095db41d287d401ecfeae2dc5
Autor:
Emily F. Mendez, Sandra L. Grimm, Laura Stertz, Damian Gorski, Sai V. Movva, Katherine Najera, Karla Moriel, Thomas D. Meyer, Gabriel R. Fries, Cristian Coarfa, Consuelo Walss-Bass
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionHuman-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as
Externí odkaz:
https://doaj.org/article/e69ef664aef746999f9747cf0a007401
Autor:
Sandra L. Grimm, Emily F. Mendez, Laura Stertz, Thomas D. Meyer, Gabriel R. Fries, Tanmay Gandhi, Rupa Kanchi, Sudhakar Selvaraj, Antonio L. Teixeira, Thomas R. Kosten, Preethi Gunaratne, Cristian Coarfa, Consuelo Walss-Bass
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
IntroductionTo understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobio
Externí odkaz:
https://doaj.org/article/30ce589188ff4ac08d007ac66ff28274
Autor:
Lucca Pizzato Tondo, Thiago Wendt Viola, Gabriel R. Fries, Bruno Kluwe-Schiavon, Leonardo Mello Rothmann, Renata Cupertino, Pedro Ferreira, Alexandre Rosa Franco, Scott D. Lane, Laura Stertz, Zhongming Zhao, Ruifeng Hu, Thomas Meyer, Joy M. Schmitz, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract White matter (WM) abnormalities in patients with cocaine use disorder (CUD) have been studied; however, the reported effects on the human brain are heterogenous and most results have been obtained from male participants. In addition, biologi
Externí odkaz:
https://doaj.org/article/5e8c57109d434cb0a66f0fda1c82cff9
Autor:
Emily Mendez, Laura Stertz, Gabriel Fries, Ruifeng Hu, Thomas Meyer, Zhongming Zhao, Consuelo Walss-Bass
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 115-115 (2021)
ABSTRACT IMPACT: This project will use human neuron models and bioinformatics techniques to elucidate mechanisms of cocaine neurotoxicity, which will allow treatments to be developed for minimizing or preventing neurological damage caused by cocaine
Externí odkaz:
https://doaj.org/article/6790f2584b4d4b0faa79f6e39eab882c
Autor:
Emily Frances Mendez, Laura Stertz, Gabriel Fries, Ruifeng Hu, Thomas Meyer, Zhongming Zhao, Consuelo Walss-Bass
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 140-140 (2020)
OBJECTIVES/GOALS: The goal of this project is to identify new therapeutic targets and biomarkers to treat or prevent cocaine toxicity by investigating proteomic, transcriptomic and epigenetic signatures of cocaine exposure in human subjects. METHODS/
Externí odkaz:
https://doaj.org/article/ed85772ef519414c90254bba25c9160a
Autor:
Letícia Scheidt, Gabriel Rodrigo Fries, Laura Stertz, João Carlos Centurion Cabral, Flávio Kapczinski, Rosa Maria Martins de Almeida
Publikováno v:
Trends in Psychiatry and Psychotherapy, Vol 37, Iss 3, Pp 143-151 (2015)
Objective:To investigate the effects of ethanol exposure in adolescent rats during adulthood by assesssing aggression and anxiety-like behaviors and measuring the levels of inflammatory markers.Methods:Groups of male Wistar rats (mean weight 81.4 g,
Externí odkaz:
https://doaj.org/article/165566ed664e437684ac51c2900bd18b
Autor:
Cristiano Brum, Laura Stertz, Ericksen Borba, Danielle Rumi, Flávio Kapczinski, Analuiza Camozzato
Publikováno v:
Brazilian Journal of Psychiatry, Vol 37, Iss 3, Pp 197-202 (2015)
Objective:To evaluate brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-α (TNF-α) blood levels as disease biomarkers of delirium in oncology inpatients.Methods:Seventeen oncology inpatients with delirium, 28 oncology inpatients wit
Externí odkaz:
https://doaj.org/article/fb65ff9804d24d3f9023773c5e1f60f2
Publikováno v:
AJOB Neuroscience. 13:111-113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5958fd1d41f78e9caec728d1451e6d
https://doi.org/10.1080/21507740.2022.2048730
https://doi.org/10.1080/21507740.2022.2048730
Autor:
Zhongming Zhao, Shan Jiang, Gabriel Rodrigo Fries, Consuelo Walss-Bass, Yulin Dai, Thomas Meyer, Ruifeng Hu, Emily Mendez, Andi Liu, Peilin Jia, Katherine Najera, Laura Stertz
Publikováno v:
International Journal of Neuropsychopharmacology
Background Opioid use disorder (OUD) affects millions of people, causing nearly 50 000 deaths annually in the United States. While opioid exposure and OUD are known to cause widespread transcriptomic and epigenetic changes, few studies in human sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d14ce7d85842b022f4dd0d9c8c9eab
http://europepmc.org/articles/PMC8598308
http://europepmc.org/articles/PMC8598308