Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Laura Mennuni"'
Autor:
Gianfranco Caselli, Albino Bonazzi, Marco Lanza, Flora Ferrari, Daniele Maggioni, Cristian Ferioli, Roberto Giambelli, Eleonora Comi, Silvia Zerbi, Marco Perrella, Ornella Letari, Elena Di Luccio, Milena Colovic, Stefano Persiani, Tiziano Zanelli, Laura Mennuni, Tiziana Piepoli, Lucio Claudio Rovati
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-19 (2018)
Abstract Background Prostaglandin E2 (PGE2) acts via its EP4 receptor as a cytokine amplifier (e.g., interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th) lymphocytes. These mechanisms play a key role in the
Externí odkaz:
https://doaj.org/article/22fc8ca4e2234150b60717587ab81196
Autor:
Cinzia Maria Francini, Francesca Musumeci, Anna Lucia Fallacara, Lorenzo Botta, Alessio Molinari, Roberto Artusi, Laura Mennuni, Adriano Angelucci, Silvia Schenone
Publikováno v:
Molecules, Vol 23, Iss 9, p 2369 (2018)
Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and EMA, respectively, and the majority are antineoplastic drugs. Morevoer, many candidates ar
Externí odkaz:
https://doaj.org/article/0c35cc55b1d7482897fe671e6e6dc190
Autor:
Andrea Cappelli, Gianluca Giorgi, Maurizio Anzini, Laura Mennuni, Marco Paolino, Germano Giuliani, Marco Lanza, Gianfranco Caselli, Annalisa Reale, Cinzia Maria Francini, Chiara Sabatini, Federica Castriconi, Giorgio Grisci
Two small series of quinoline derivatives were designed starting from previously published quinoline derivatives 7a and b in order to obtain information about their interaction with the 5-HT(4)R binding site. Initially, the structure of 7a and b was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6922e480121d3872aa6b5a52d16521
https://europepmc.org/articles/PMC6148519/
https://europepmc.org/articles/PMC6148519/
Autor:
Federica, Castriconi, Marco, Paolino, Alessandro, Donati, Germano, Giuliani, Maurizio, Anzini, Laura, Mennuni, Chiara, Sabatini, Marco, Lanza, Gianfranco, Caselli, Francesco, Makovec, Maria, Sbraccia, Paola, Molinari, Tommaso, Costa, Andrea, Cappelli
Multivalency does not improve the binding and functional activities of ML10302 at 5-HT4 receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f2cecbc39613f6395848f8ad2e85b7f9
https://europepmc.org/articles/PMC6071950/
https://europepmc.org/articles/PMC6071950/
Autor:
Marco Paolino, Maurizio Anzini, Laura Mennuni, Paola Molinari, Francesco Makovec, Andrea Cappelli, Federica Castriconi, Maria Sbraccia, Tommaso Costa, Gianfranco Caselli, Chiara Sabatini, Marco Lanza, Alessandro Donati, Germano Giuliani
5-HT4 receptors are known to form constitutive dimers in membranes. To explore whether multivalency can enhance ligand interactions and/or efficacy in 5-HT4 receptors, the structure of the partial agonist ML10302 was modified with oligo(ethylene glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecb172b9b08578705cd4704fd92e185
http://hdl.handle.net/11365/1005015
http://hdl.handle.net/11365/1005015
Autor:
Maurizio Anzini, Germano Giuliani, Gianfranco Caselli, Maria Cristina Menziani, Antonio Giordani, Andrea Cappelli, Chiara Sabatini, Marco Paolino, Alessia Chelini, Laura Mennuni, Chiara Nannicini, Francesco Makovec, Gianluca Giorgi, Salvatore Vomero
Two new fluorophenylindenone derivatives were designed as potential p38α MAPK modulators by preserving the key interactions of the vicinal pyridine/fluorophenyl pharmacophore with the enzyme protein. Interestingly, these two fluorophenylindenone iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b3d971c122757490d6f923b3acf13c
http://hdl.handle.net/11365/998341
http://hdl.handle.net/11365/998341
Autor:
Kanji Bhimani, Gianfranco Caselli, Sabrina Pucci, Luca Canciani, Cristian Ferioli, Tiziana Piepoli, Mehul Kaswala, Silvia Zerbi, Manuela Borriello, Tiziano Zanelli, Laura Mennuni, Luigi Piero Stasi, Matteo Salvi, Fabrizio Colace, Vikas Shirsath
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6336-6340
The construction of a EP(4) antagonists pharmacophore model and the discovery of a highly potent oxepinic series of EP(4) antagonists is discussed. Compound 1a exhibits an excellent selectivity profile toward EP(2) receptor subtype and low cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9e44d8000dd6e21652d2b3d1ec880c
https://doi.org/10.1016/j.bmcl.2011.08.102
https://doi.org/10.1016/j.bmcl.2011.08.102
Autor:
Salvatore Vomero, Gianluca Giorgi, Salvatore Valenti, Francesco Makovec, Antonio Giordani, Maurizio Anzini, Gianfranco Caselli, Luigi Piero Stasi, Germano Giuliani, Laura Mennuni, Andrea Cappelli, Chiara Nannicini
Publikováno v:
ChemMedChem. 5:739-748
A small set of aggrecanase inhibitors based on the pyrrolo[3,4-c]quinolin-1-one or oxoisoindoline frameworks bearing a 4-(benzyloxy)phenyl substituent and different zinc binding groups were rationally designed and evaluated in silico by docking studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617b402e3920592626cd378c85b05c92
https://doi.org/10.1002/cmdc.200900523
https://doi.org/10.1002/cmdc.200900523
Autor:
Gianfranco Caselli, Silvia Zerbi, Tiziana Piepoli, Laura Mennuni, Marco Lanza, Lucio C. Rovati
Publikováno v:
Osteoarthritis and Cartilage. 17(8):1076-1083
Summary Objective Increased levels of glutamate, the main excitatory neurotransmitter, are found in the synovial fluid of osteoarthritis (OA) patients. Our aim was to study glutamate signaling in chondrocytes, focusing on the composition, pharmacolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b3f7c4378b82c6100ae16655a960cb
Autor:
Antonio Varnavas, Federico Berti, Theodoros Markidis, Francesco Makovec, Laura Mennuni, George Kokotos, Lucia Lassiani, Michela V. Pavan
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2336-2350
The anthranilic acid diamides represent the more recent class of nonpeptide CCK(1) receptor antagonists. This class is characterized by the presence of anthranilic acid, used as a molecular scaffold, and two pharmacophores selected from the C-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db791ac364cb18aa427415ab456a8e83
https://doi.org/10.1016/j.bmc.2009.02.012
https://doi.org/10.1016/j.bmc.2009.02.012