Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Laura Hammer"'
Autor:
Laura Hammer, Katia Mangano, Stacia Furtado, Ferdinando Nicoletti, Dominick L. Auci, Benjamin Green, Edith Mathiowitz
Publikováno v:
Inflamm Bowel Dis
Background All-trans retinoic acid (ATRA) is a biologically active isomer of retinoic acid (RA). Topical ATRA (retin-a, retin-a micro, atralin, renova, and avita) is the active pharmaceutical ingredient for FDA-approved treatments for acne and skin w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9798b5326dd2c488cbc268a0230af1ac
https://pubmed.ncbi.nlm.nih.gov/34417826
https://pubmed.ncbi.nlm.nih.gov/34417826
Publikováno v:
World Journal of Gastrointestinal Pharmacology and Therapeutics
BACKGROUND TreXTAM® is a combination of the key regulatory cytokine transforming growth factor beta (TGFβ) and all trans retinoic acid (ATRA) microencapsulated for oral delivery to immune structures of the gut. It is in development as a novel treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e7d59cb40bc5d7ac5c71b228be018a
https://pubmed.ncbi.nlm.nih.gov/33251033
https://pubmed.ncbi.nlm.nih.gov/33251033
Autor:
Michael W. Russell, Laura Hammer, Yingru Liu, Nejat K. Egilmez, Magdia De Jesus, Julianny Perez, Heather C. Gallagher
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
mSphere, Vol 3, Iss 1, p e00421-17 (2018)
mSphere, Vol 3, Iss 1, p e00421-17 (2018)
It has previously been shown that genital tract infection with Neisseria gonorrhoeae in mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses against N. gonorrhoeae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d60d82567af3e2728344551c91094e2
https://doi.org/10.1128/msphere.00421-17
https://doi.org/10.1128/msphere.00421-17
Autor:
Stacia Furtado, Nejat K. Egilmez, Thomas F. Conway, Ferdinando Nicoletti, Edith Mathiowitz, Laura Hammer, Katia Mangano, Dominick L. Auci
Background and aims: We investigated oral delivery of transforming growth factor beta 1 [TGFβ]- and all-trans retinoic acid [ATRA]-loaded microspheres as therapy for gut inflammation in murine models of inflammatory bowel disease [IBD]. Methods: ATR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25d0e8194b5ed531dfac21b4a21c84f
http://hdl.handle.net/20.500.11769/44508
http://hdl.handle.net/20.500.11769/44508
Autor:
Thor Roalsvig, Jomary A. Honeyman, Gary Whiting, Choung U. Kim, Sterzycki Roman Z, Jacek Ostrowski, John E. Starrett, Peter R. Reczek, Muzammil M. Mansuri, Simon Chen, Barbara Kwasniewski, Kuo-Long Yu, Laura Hammer, Stephen J. Currier
Publikováno v:
Journal of Investigative Dermatology. 104(5):779-783
Among retinoic acid receptors (RARs) alpha, beta, and gamma, the messenger RNA level of RAR-gamma is the most readily detectable by Northern blotting in human and mouse skin. This observation suggests that RAR-gamma may play a critical role in the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67db9e0e376c99e5939c4c82dda3c840
Publikováno v:
Proceedings of the National Academy of Sciences. 92:1812-1816
Utilizing a strategy involving domain exchange between retinoic acid receptors alpha and beta (RAR alpha and RAR beta) and monitoring the transcriptional activity of the resulting chimeric receptors with receptor-selective retinoids, we identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbe7a802c26c4c06f0946c133cdfebf
https://doi.org/10.1073/pnas.92.6.1812
https://doi.org/10.1073/pnas.92.6.1812
Autor:
Gideon Koren, Thomas Walter, Muzammil M. Mansuri, Simon Chen, Jean Bauer, Ricard P. Carlson, Jacek Ostrowski, Joyce Phelan Driscoll, Kuo-Long Yu, Neil H. Shear, Manuela G. Neuman, Joachim Barth, Patrick G. Spinazze, D. A. Hartman, Peter R. Reczek, Gary Whiting, Bodo Lehmann, S. Matschiner, Samuel Randor, John E. Starrett, Laura Hammer, Yimin Xiong, Dwora Klein, Mei-Li A. Sung., Kenneth M. Tramposch, Reinhard H.H. Neubert, Gottfried Wozel, Yeung W. Lock, Thor Roalsvig, Keith B. Glaser, Dierk Steinmann, Wolfgang Wohlrab, Charles S. Harmon, Izabella M. Malkiewicz
Publikováno v:
Skin Pharmacology and Physiology. 8:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5968fd863a16cb0c9a32b79a9825577
https://doi.org/10.1159/000211358
https://doi.org/10.1159/000211358
Autor:
Kuo-Long Yu, Laura Hammer, Jacek Ostrowski, Peter R. Reczek, John E. Starrett, Gary Whiting, Muzammil M. Mansuri, Simon Chen, Patrick G. Spinazze, Thor Roalsvig, Joyce Phelan Driscoll, Kenneth M. Tramposch
Publikováno v:
Skin Pharmacology and Physiology. 8:292-299
The three retinoic acid receptors (RARΑ, RARΒ and RARΓ) are known to modulate the transcription of target genes through interaction of the individual receptors with their naturally occurring ligand, retinoic acid (RA). Since RA has multiple effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d70bbdf308353faa01b35cad7b7e55
https://doi.org/10.1159/000211360
https://doi.org/10.1159/000211360
Autor:
Thor Roalsvig, David R. Tortolani, Kuo-Long Yu, Jomary A. Honeyman, Laura Hammer, Patrick G. Spinazze, Peter R. Reczek, Stephen J. Currier, Muzammil M. Mansuri, John E. Starrett, Jacek Ostrowski, Edward J. Pack
Publikováno v:
ChemInform. 27
In search for retinoic acid receptor (RAR) selective ligands, a series of 6-substituted 2-naphthoic acid retinoids were synthesized and evaluated in vitro in a transactivation assay and a competition binding assay for all RARs. These derivatives, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f71896cf838c02e0988bf39b26ac888
https://doi.org/10.1002/chin.199638128
https://doi.org/10.1002/chin.199638128
Publikováno v:
Cancer biotherapyradiopharmaceuticals. 19(6)
Controlled-release, injectable polymer microspheres provide a clinically feasible alternative to gene-modification for the local, sustained delivery of cytokines to tumors for cancer immunotherapy. Long-term release kinetics, bioactivity profiles, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0437d9ea5093f72e5ad0be0f91c962ec
https://pubmed.ncbi.nlm.nih.gov/15665625
https://pubmed.ncbi.nlm.nih.gov/15665625