Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Laura Aldegheri"'
Autor:
Caterina Virginio, Laura Aldegheri, Selena Nola, Daniela Brodbeck, Laurent Brault, Luca F. Raveglia, Alessio Barilli, Mark Sabat, Richard Myers
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 55-64 (2022)
Transient Receptor Potential Melastatin 5 (TRPM5) is an intracellular calcium-activated cation-selective ion channel expressed in a variety of cell types. Dysfunction of this channel has recently been implied in a range of disease states including di
Externí odkaz:
https://doaj.org/article/4cf64e986b4845aa93cac6e858d386ee
Autor:
Raveglia Luca Francesco, Richard M. Myers, Caterina Virginio, Mark Sabat, Daniela Brodbeck, Laurent Brault, Selena Nola, Alessio Barilli, Laura Aldegheri
Publikováno v:
SLAS Discovery. 27:55-64
Transient Receptor Potential Melastatin 5 (TRPM5) is an intracellular calcium-activated cation-selective ion channel expressed in a variety of cell types. Dysfunction of this channel has recently been implied in a range of disease states including di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feac2b5c5ecd8e0a04d427042b52264e
https://doi.org/10.1016/j.slasd.2021.10.004
https://doi.org/10.1016/j.slasd.2021.10.004
Autor:
Daniela Pompilio, Sabrina Tassini, Laura Piccoli, Alessio Barilli, Aldo Feriani, Daniela Brodbeck, Laura Castelletti, Raveglia Luca Francesco, Laurent Brault, Iain Lingard, Laura Aldegheri, Federica Bianchi, Mark Sabat, Richard M. Myers, Caterina Virginio, Selena Nola, Cristian Salvagno
Publikováno v:
Journal of Medicinal Chemistry. 64:5931-5955
Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a nonselective monovalent cation channel activated by intracellular Ca2+ increase. Within the gastrointestinal system, TRPM5 is expressed in the stoma, small intestine, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::276f841154741494c801408c590e8d10
https://doi.org/10.1021/acs.jmedchem.1c00065
https://doi.org/10.1021/acs.jmedchem.1c00065
Autor:
Marie L. Woolley, Lee A. Dawson, Elisa Ballini, Kerry A. Waters, Mark H Harries, Laura Aldegheri, Simon E. Ward, Joanne Pardoe, Laurent Lacroix, John R. Atack, Kathryn R. Starr, Annette Weil, Andrea M. Bradford
Publikováno v:
J Psychopharmacol
Purpose: There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of ionotropic glutamate receptors as therapeutic agents for a range of cognitive and mood disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc536032e13d6250b637c40721273ae8
https://doi.org/10.1177/0269881119872198
https://doi.org/10.1177/0269881119872198
Autor:
Alessio, Barilli, Laura, Aldegheri, Federica, Bianchi, Laurent, Brault, Daniela, Brodbeck, Laura, Castelletti, Aldo, Feriani, Iain, Lingard, Richard, Myers, Selena, Nola, Laura, Piccoli, Daniela, Pompilio, Luca F, Raveglia, Cristian, Salvagno, Sabrina, Tassini, Caterina, Virginio, Mark, Sabat
Publikováno v:
Journal of medicinal chemistry. 64(9)
Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a nonselective monovalent cation channel activated by intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d619050999d16fbf323a8d84594fd590
https://pubmed.ncbi.nlm.nih.gov/33890770
https://pubmed.ncbi.nlm.nih.gov/33890770
Autor:
Francesca Graziani, Marcelo D. Rosato-Siri, Roberto Benedetti, Laura Aldegheri, Nicoletta Garbati, Caterina Virginio, Giuseppe Alvaro, Chiara Mutinelli, Erika Zambello, Charles H. Large
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:251-260
Kv3.1 and Kv3.2 high voltage-activated potassium channels, which display fast activation and deactivation kinetics, are known to make a crucial contribution to the fast-spiking phenotype of certain neurons. Pharmacological experiments show that the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad3e0dcc34d7f6c593a591cbd785ac2
https://doi.org/10.1124/jpet.115.225748
https://doi.org/10.1124/jpet.115.225748
Autor:
Andrew J. Powell, SJ Medhurst, I Lago, YH Chen, Caterina Virginio, Elisa Ballini, A Buson, Laura Aldegheri, Wolfgang Jarolimek, Angelo Giacometti, Scott G. Summerfield, Corrado Carignani
Publikováno v:
British Journal of Pharmacology. 163:1315-1325
BACKGROUND AND PURPOSE P2X3 and P2X2/3 receptors are highly localized on the peripheral and central pathways of nociceptive signal transmission. The discovery of A-317491 allowed their validation as chronic inflammatory and neuropathic pain targets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfc5cb5618f6069f6fd999a3e92cfa6
https://doi.org/10.1111/j.1476-5381.2011.01322.x
https://doi.org/10.1111/j.1476-5381.2011.01322.x
Autor:
Kevin M. Thewlis, Simon E. Ward, Beatrice Oliosi, Mark H Harries, Claudette Mookherjee, Laura Aldegheri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7116-7119
A series of novel AMPA receptor positive modulators displaying CNS penetration have been discovered with sub-micromolar activity and good selectivity over the cardiac channel receptor, hERG. We describe here the synthesis of these compounds which are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453510f26dffd06f49d33b6ffe79f3e0
https://doi.org/10.1016/j.bmcl.2010.09.062
https://doi.org/10.1016/j.bmcl.2010.09.062
Autor:
Caterina Virginio, Angelo Giacometti, Georg C. Terstappen, Joseph M. Rimland, Laura Aldegheri
Publikováno v:
European Journal of Pharmacology. 445:153-161
The pharmacological properties of the rat alpha7 nicotinic acetylcholine receptor endogenously expressed in PC12 cells and recombinantly expressed in GH4C1 cells (alpha7-GH4C1 cells) were characterized and compared. Patch-clamp recordings demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795f81111a0b3815b496b976705936e4
https://doi.org/10.1016/s0014-2999(02)01750-8
https://doi.org/10.1016/s0014-2999(02)01750-8
Publikováno v:
SLAS Discovery. 5:255-261
For the identification of modulators of the metabotropic glutamate receptor mGluR7, a functional cell-based high throughput screening (HTS) assay was developed. This assay utilizes the signal transduction pathway of mGluR7, which is negatively couple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8915f84ca035d1f77ed2140c9733b9
https://doi.org/10.1177/108705710000500408
https://doi.org/10.1177/108705710000500408