Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Laura, Torella"'
Autor:
Gracián Camps, Sheila Maestro, Laura Torella, Diego Herrero, Carla Usai, Martin Bilbao-Arribas, Ana Aldaz, Cristina Olagüe, Africa Vales, Lester Suárez-Amarán, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1011749 (2024)
Hepatitis delta virus (HDV) infection represents the most severe form of human viral hepatitis; however, the mechanisms underlying its pathology remain incompletely understood. We recently developed an HDV mouse model by injecting adeno-associated vi
Externí odkaz:
https://doaj.org/article/f65b905aaaa044dfbfa7b73578b995c9
Autor:
Cavazza, Alessia, Hendel, Ayal, Bak, Rasmus O., Rio, Paula, Güell, Marc, Lainšček, Duško, Arechavala-Gomeza, Virginia, Peng, Ling, Hapil, Fatma Zehra, Harvey, Joshua, Ortega, Francisco G., Gonzalez-Martinez, Coral, Lederer, Carsten W., Mikkelsen, Kasper, Gasiunas, Giedrius, Kalter, Nechama, Gonçalves, Manuel A.F.V., Petersen, Julie, Garanto, Alejandro, Montoliu, Lluis, Maresca, Marcello, Seemann, Stefan E., Gorodkin, Jan, Mazini, Loubna, Sanchez, Rosario, Rodriguez-Madoz, Juan R., Maldonado-Pérez, Noelia, Laura, Torella, Schmueck-Henneresse, Michael, Maccalli, Cristina, Grünewald, Julian, Carmona, Gloria, Kachamakova-Trojanowska, Neli, Miccio, Annarita, Martin, Francisco, Turchiano, Giandomenico, Cathomen, Toni, Luo, Yonglun, Tsai, Shengdar Q., Benabdellah, Karim
Publikováno v:
In Molecular Therapy - Nucleic Acids 12 December 2023 34
Autor:
Maria Giorgalli, Deirdre A. Cunningham, Malgorzata Broncel, Aaron Sait, Thomas E. Harrison, Caroline Hosking, Audrey Vandomme, Sarah I. Amis, Ana Antonello, Lauren Sullivan, Faith Uwadiae, Laura Torella, Matthew K. Higgins, Jean Langhorne
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Plasmodium multigene families are thought to play important roles in the pathogenesis of malaria. Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium species. However, their expression pattern and local
Externí odkaz:
https://doaj.org/article/fdfc5059f3df4ec5b76c252da4225093
Autor:
Sergio López-Manzaneda, Isabel Ojeda-Pérez, Nerea Zabaleta, Aída García-Torralba, Omaira Alberquilla, Raúl Torres, Rebeca Sánchez-Domínguez, Laura Torella, Emmanuel Olivier, Joanne Mountford, Juan C. Ramírez, Juan A. Bueren, Gloria González-Aseguinolaza, Jose-Carlos Segovia
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 426-437 (2020)
The development of advanced gene and cell therapies for the treatment of genetic diseases requires reliable animal and cellular models to test their efficacy. Moreover, the availability of the target human primary cells of these therapies is reduced
Externí odkaz:
https://doaj.org/article/a89d25dc6deb4878ad9c49dd61bdf7ef
Autor:
Nerea Zabaleta, Miren Barberia, Cristina Martin-Higueras, Natalia Zapata-Linares, Isabel Betancor, Saray Rodriguez, Rebeca Martinez-Turrillas, Laura Torella, Africa Vales, Cristina Olagüe, Amaia Vilas-Zornoza, Laura Castro-Labrador, David Lara-Astiaso, Felipe Prosper, Eduardo Salido, Gloria Gonzalez-Aseguinolaza, Juan R. Rodriguez-Madoz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Substrate reduction therapies (SRT) are a promising therapeutic approach for monogenic inherited metabolic diseases. Here the authors evaluate the therapeutic potential of an in vivo CRISPR/Cas9-mediated SRT to treat primary hyperoxaluria type I and
Externí odkaz:
https://doaj.org/article/4b179c1567b1437ea464d69ab6bf5455
Autor:
Alessandro Orsini, Andrea Santangelo, Francesca Bravin, Alice Bonuccelli, Diego Peroni, Roberta Battini, Thomas Foiadelli, Veronica Bertini, Angelo Valetto, Michele Iacomino, Vincenzo Nigro, Anna Laura Torella, Marcello Scala, Valeria Capra, Maria Stella Vari, Anna Fetta, Veronica Di Pisa, Francesca Montanari, Roberta Epifanio, Paolo Bonanni, Roberto Giorda, Francesca Operto, Grazia Pastorino, Esra Sarigecili, Esra Sardaroglu, Cetin Okuyaz, Sevgan Bozdogan, Luciana Musante, Flavio Faletra, Caterina Zanus, Alessandro Ferretti, Federico Vigevano, Pasquale Striano, Duccio Maria Cordelli
Publikováno v:
Genes, Vol 13, Iss 2, p 276 (2022)
Background: Poirier–Bienvenu Neurodevelopmental Syndrome (POBINDS) is a rare disease linked to mutations of the CSNK2B gene, which encodes for a subunit of caseinkinase CK2 involved in neuronal growth and synaptic transmission. Its main features in
Externí odkaz:
https://doaj.org/article/e3d8e33fe59843afb365458cc3fe28a6
Autor:
Nicola Laforgia, Manuela Capozza, Lucrezia De Cosmo, Antonio Di Mauro, Maria Elisabetta Baldassarre, Francesca Mercadante, Anna Laura Torella, Vincenzo Nigro, Nicoletta Resta
Publikováno v:
Case Reports in Genetics, Vol 2018 (2018)
Congenital myopathies are a group of rare inherited diseases, defined by hypotonia and muscle weakness. We report clinical and genetic characteristics of a male preterm newborn, whose phenotype was characterized by severe hypotonia and hyporeactivity
Externí odkaz:
https://doaj.org/article/b11466e850824b1dad55af73773c458f
Autor:
Joanne C. Mountford, Rebeca Sanchez-Dominguez, Isabel Ojeda-Perez, Raul M. Torres, Gloria González-Aseguinolaza, Juan C. Ramirez, Aída Garcia-Torralba, Nerea Zabaleta, Sergio López-Manzaneda, Laura Torella, José C. Segovia, Emmanuel Olivier, Juan A. Bueren, Omaira Alberquilla
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 426-437 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The development of advanced gene and cell therapies for the treatment of genetic diseases requires reliable animal and cellular models to test their efficacy. Moreover, the availability of the target human primary cells of these therapies is reduced
Publikováno v:
Hepatology (Baltimore, Md.). 76(3)
The efficient delivery of RNA molecules to restore the expression of a missing or inadequately functioning protein in a target cell and the intentional specific modification of the host genome using engineered nucleases represent therapeutic concepts
Autor:
Sergio López-Manzaneda, Laura Torella, Raul M. Torres, Isabel Ojeda-Perez, Nerea Zabaleta, José C. Segovia, Juan C. Ramirez, Juan A. Bueren, Omaira Alberquilla, Rebeca Sanchez-Dominguez, Joanne C. Mountford, Aída Garcia-Torralba, Emmanuel Olivier, Gloria González-Aseguinolaza
Development of advanced gene and cell therapies for the treatment of genetic diseases requires confident animal and cellular models to test their efficacy and is crucial in the cases where no primary samples from patients are available. CRISPR/Cas9 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b4b6a24380c8c3fbd197f1493ff61