Testing calpain inhibition in tumor endothelial cells: novel targetable biomarkers against glioblastoma malignancy

Autor: Laura Guarnaccia, Stefania Elena Navone, Laura Begani, Emanuela Barilla, Emanuele Garzia, Rolando Campanella, Monica Miozzo, Laura Fontana, Giovanni Alotta, Chiara Cordiglieri, Chiara Gaudino, Luigi Schisano, Antonella Ampollini, Laura Riboni, Marco Locatelli, Giovanni Marfia

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionGlioblastoma IDH-wildtype (GBM) is the most malignant brain tumor in adults, with a poor prognosis of approximately 15 months after diagnosis. Most patients suffer from a recurrence in

Externí odkaz: https://doaj.org/article/4ff36f582b654f4c962dae7e5c58ef3e

Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19

Autor: Giovanni Marfia, Stefania Navone, Laura Guarnaccia, Rolando Campanella, Michele Mondoni, Marco Locatelli, Alessandra Barassi, Laura Fontana, Fabrizio Palumbo, Emanuele Garzia, Giuseppe Ciniglio Appiani, Davide Chiumello, Monica Miozzo, Stefano Centanni, Laura Riboni

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-11 (2020)

Abstract The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐

Externí odkaz: https://doaj.org/article/3b2fac23170b4cebacddf12bd1e27b7d

Frontiers in Anti-Cancer Drug Discovery: Challenges and Perspectives of Metformin as Anti-Angiogenic Add-On Therapy in Glioblastoma

Autor: Laura Guarnaccia, Giovanni Marfia, Matteo Maria Masseroli, Stefania Elena Navone, Melissa Balsamo, Manuela Caroli, Silvia Valtorta, Rosa Maria Moresco, Rolando Campanella, Emanuele Garzia, Laura Riboni, Marco Locatelli

Publikováno v: Cancers, Vol 14, Iss 112, p 112 (2022)
Cancers
Cancers (Basel) 14 (2022): 112.. doi:10.3390/cancers14010112
info:cnr-pdr/source/autori:Guarnaccia L.; Marfia G.; Masseroli M.M.; Navone S.E.; Balsamo M.; Caroli M.; Valtorta S.; Moresco R.M.; Campanella R.; Garzia E.; Riboni L.; Locatelli M./titolo:Frontiers in Anti-Cancer Drug Discovery: Challenges and Perspectives of Metformin as Anti-Angiogenic Add-On Therapy in Glioblastoma/doi:10.3390%2Fcancers14010112/rivista:Cancers (Basel)/anno:2022/pagina_da:112./pagina_a:/intervallo_pagine:112./volume:14

Simple Summary Glioblastoma is the most aggressive primary brain tumor, with the highest incidence and the worst prognosis. Life expectancy from diagnosis remains dismal, at around 15 months, despite surgical resection and treatment with radiotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d72149fc382cebb99ee88ce4be7f19
https://www.mdpi.com/2072-6694/14/1/112

Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology

Autor: Rolando Campanella, Laura Guarnaccia, Chiara Cordiglieri, Elena Trombetta, Manuela Caroli, Giorgio Carrabba, Nicla La Verde, Paolo Rampini, Chiara Gaudino, Antonella Costa, Sabino Luzzi, Giovanna Mantovani, Marco Locatelli, Laura Riboni, Stefania Elena Navone, Giovanni Marfia

Publikováno v: Cells, Vol 9, Iss 2, p 294 (2020)

Circulating platelets (PLTs) are able to affect glioblastoma (GBM) microenvironment by supplying oncopromoter and pro-angiogenic factors. Among these mediators, sphingosine-1-phophate (S1P) has emerged as a potent bioactive lipid enhancing cell proli

Externí odkaz: https://doaj.org/article/847eeeb8300a4993b2f9b0cb3fcd2357

Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces

Autor: Loubna Abdel Hadi, Clara Di Vito, Laura Riboni

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in

Externí odkaz: https://doaj.org/article/3707a3bde77f46f9be5540b728dee920