Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Laura, Prickett"'
Autor:
Anna D. Staniszewska, Joshua Armenia, Matthew King, Chrysiis Michaloglou, Avinash Reddy, Maneesh Singh, Maryann San Martin, Laura Prickett, Zena Wilson, Theresa Proia, Deanna Russell, Morgan Thomas, Oona Delpuech, Mark J. O’Connor, Elisabetta Leo, Helen Angell, Viia Valge-Archer
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
PARP inhibitors are synthetically lethal with BRCA1/2 mutations, and in this setting, accumulation of DNA damage leads to cell death. Because increased DNA damage and subsequent immune activation can prime an anti-tumor immune response, we studied th
Externí odkaz:
https://doaj.org/article/42e14e70567c4dc0ac16e7566635a844
Autor:
Alexandra, Borodovsky, Christine M, Barbon, Yanjun, Wang, Minwei, Ye, Laura, Prickett, Dinesh, Chandra, Joseph, Shaw, Nanhua, Deng, Kris, Sachsenmeier, James D, Clarke, Bolan, Linghu, Giles A, Brown, James, Brown, Miles, Congreve, Robert Ky, Cheng, Andrew S, Dore, Edward, Hurrell, Wenlin, Shao, Richard, Woessner, Corinne, Reimer, Lisa, Drew, Stephen, Fawell, Alwin G, Schuller, Deanna A, Mele
Publikováno v:
Journal for Immunotherapy of Cancer
Accumulation of extracellular adenosine within the microenvironment is a strategy exploited by tumors to escape detection by the immune system. Adenosine signaling through the adenosine 2A receptor (A2AR) on immune cells elicits a range of immunosupp
Autor:
Yanjun Wang, Philip B. Rawlins, S. Bagal, Laura Prickett, James Robinson, Andrew Bloecher, Minhui Shen, Alan Rosen, Haley Woods, Maryann San Martin, Erin Code, Jessie Hao-Ru Hsu, Sasha Borodovsky
Publikováno v:
Blood. 138:2274-2274
The polycomb repressive complex 2(PRC2), consisting of the core subunits EED, EZH2, and SUZ12, is frequently overexpressed and deregulated in hematological and solid malignancies. Clinical validation for targeting the PRC2 complex has been demonstrat
Autor:
Horma Ghadially, Kristina M. Ilieva, Scott Mlynarski, Alwin Schuller, Theresa Proia, Wenlin Shao, Eric Gangl, Sharon Tentarelli, Aatman Doshi, Susan Cantin, Michael Secinaro, Yanjun Wang, Laura Prickett, Ray Finlay
Publikováno v:
Cancer Research. 80:4523-4523
The tumor microenvironment (TME) has multiple mechanisms of immune-suppression, one being recruitment of arginase (ARG) expressing myeloid cells. ARG is an enzyme that catalyzes hydrolysis of L-arginine into urea and L-ornithine. L-arginine is a semi
Autor:
Dinesh Chandra, Minwei Ye, Christine M. Barbon, Kris Sachsenmeier, Deanna A. Mele, Wenlin Shao, Carl Barrett, Stephen Fawell, Yanjun Wang, Alwin Schuller, Alexandra Borodovsky, Laura Prickett
Publikováno v:
Cancer Immunology Research. 8:A87-A87
Adenosine signaling via the adenosine 2A receptor (A2AR) is emerging as an important regulatory mechanism of immune responses. Adenosine levels are increased in the tumor microenvironment by the CD39/CD73 axis and adenosine signaling through the aden
Autor:
Noel R. Monks, Maryann San Martin, Corinne Reimer, Griffin Matthew, Maneesh Singh, Lisa Drew, Laura Bradshaw, Theresa Proia, Simon T. Barry, Laura Prickett
Publikováno v:
Cancer Research. 81:1813-1813
The complex interplay between the immune system and cancer cells is challenging to model in preclinical species. Many commonly mutated genes that influence tumorigenesis actively participate in the activation, recruitment or suppression of the immune
Autor:
Carl Barrett, Alwin Schuller, Deanna A. Mele, Stephen Fawell, Kris Sachsenmeier, Laura Prickett, Yanjun Wang, Alexandra Borodovsky, Christine M. Barbon, Wenlin Shao
Publikováno v:
Cancer Research. 79:LB-192
Adenosine signaling is a normal physiologic process preventing autoimmunity, that is co-opted by tumors as an immune escape mechanism. Dendritic cells (DC), generated from human monocytes or mouse bone marrow, are susceptible to the immunosuppressive
Autor:
Edward Hurrell, James A. Brown, Andrew S. Doré, Christine M. Barbon, Stephen Fawell, Robert K. Y. Cheng, Bolan Linghu, Giles A. Brown, Joseph Shaw, Kris Sachsenmeier, Alexandra Borodovsky, Minwei Ye, Alwin Schuller, Wenlin Shao, Dinesh Chandra, James D. Clarke, Yanjun Wang, Laura Prickett, Miles Congreve, Lisa Drew, Corinne Reimer, Deanna A. Mele, Richard Woessner, Nanhua Deng
Publikováno v:
Journal for ImmunoTherapy of Cancer. 8:e000417
Accumulation of extracellular adenosine within the microenvironment is a strategy exploited by tumors to escape detection by the immune system. Adenosine signaling through the adenosine 2A receptor (A2AR) on immune cells elicits a range of immunosupp
Publikováno v:
Low Impact Development 2010.
Although sustainable green streets are becoming commonplace in pioneering cities, such as Portland, Oregon, and Seattle, Washington, it can be challenging to bring these designs into the mainstream. In 2007, the San Mateo Countywide Water Pollution P
Autor:
Jill Bicknell, Laura Prickett
Publikováno v:
Low Impact Development 2010.
The demand for developments that achieve green rating criteria continues to be strong despite the weakened economy. Many municipalities throughout the U.S. are adopting green development ordinances or policies with various environmental goals, often