Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laura, Pajed"'
Autor:
Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 93-107 (2023)
Abstract Background Cancer‐associated cachexia (CAC) is a wasting syndrome drastically reducing efficacy of chemotherapy and life expectancy of patients. CAC affects up to 80% of cancer patients, yet the mechanisms underlying the disease are not we
Externí odkaz:
https://doaj.org/article/562eec85d9b4414fbcf6d13bb3bc9bf1
Autor:
Gabriel Chalhoub, Alina Jamnik, Laura Pajed, Stephanie Kolleritsch, Victoria Hois, Antonia Bagaric, Dominik Prem, Anna Tilp, Dagmar Kolb, Heimo Wolinski, Ulrike Taschler, Thomas Züllig, Gerald N. Rechberger, Claudia Fuchs, Michael Trauner, Gabriele Schoiswohl, Guenter Haemmerle
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101725- (2023)
Objective: Hepatic triacylglycerol accumulation and insulin resistance are key features of NAFLD. However, NAFLD development and progression are rather triggered by the aberrant generation of lipid metabolites and signaling molecules including diacyl
Externí odkaz:
https://doaj.org/article/d06dd7e7ff414b97a22a56bc9746478f
Autor:
Petra Kotzbeck, Ulrike Taschler, Christoph Haudum, Ines Foessl, Gabriele Schoiswohl, Beate Boulgaropoulos, Kaddour Bounab, Johanna Einsiedler, Laura Pajed, Anna Tilp, Anna Schwarz, Thomas O. Eichmann, Barbara Obermayer-Pietsch, Antonio Giordano, Saverio Cinti, Rudolf Zechner, Thomas R. Pieber
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100305- (2023)
Hormone-sensitive lipase (HSL) plays a crucial role in intracellular lipolysis, and loss of HSL leads to diacylglycerol (DAG) accumulation, reduced FA mobilization, and impaired PPARγ signaling. Hsl knockout mice exhibit adipose tissue inflammation,
Externí odkaz:
https://doaj.org/article/80063204e648425484a550a793ab4a26
Autor:
Laura Pajed, Ulrike Taschler, Anna Tilp, Peter Hofer, Petra Kotzbeck, Stephanie Kolleritsch, Franz P. W. Radner, Isabella Pototschnig, Carina Wagner, Margarita Schratter, Sandra Eder, Sabrina Huetter, Renate Schreiber, Guenter Haemmerle, Thomas O. Eichmann, Martina Schweiger, Gerald Hoefler, Erin E. Kershaw, Achim Lass, Gabriele Schoiswohl
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Pajed et al. investigate the role of adipocyte hormone-sensitive lipase (HSL) in whole body energy homeostasis. They show that adipocyte-specific HSL Knockout (AHKO) mice fed high fat diet develop fatty liver. Interestingly, this phenotype reverses i
Externí odkaz:
https://doaj.org/article/489219dde80844a090448c922d5f0fbd
Autor:
Carina Wagner, Victoria Hois, Annalena Eggeling, Lisa-Maria Pusch, Laura Pajed, Patrick Starlinger, Thierry Claudel, Michael Trauner, Robert Zimmermann, Ulrike Taschler, Achim Lass
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100173- (2022)
Large quantities of vitamin A are stored as retinyl esters (REs) in specialized liver cells, the hepatic stellate cells (HSCs). To date, the enzymes controlling RE degradation in HSCs are poorly understood. In this study, we identified KIAA1363 (also
Externí odkaz:
https://doaj.org/article/9e072aff898e4609a2c37508d808e9c1
Autor:
Gabriel Chalhoub, Stephanie Kolleritsch, Lisa K. Maresch, Ulrike Taschler, Laura Pajed, Anna Tilp, Helgit Eisner, Philipp Rosina, Benedikt Kien, Franz P.W. Radner, Rudolf Schicho, Monika Oberer, Gabriele Schoiswohl, Guenter Haemmerle
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100075- (2021)
Carboxylesterase 2 (CES2/Ces2) proteins exert established roles in (pro)drug metabolism. Recently, human and murine CES2/Ces2c have been discovered as triglyceride (TG) hydrolases implicated in the development of obesity and fatty liver disease. The
Externí odkaz:
https://doaj.org/article/f72aae932f6c49aebeb9e5d4cbae4592
Autor:
Thomas O. Eichmann, Lukas Grumet, Ulrike Taschler, Jürgen Hartler, Christoph Heier, Aaron Woblistin, Laura Pajed, Manfred Kollroser, Gerald Rechberger, Gerhard G. Thallinger, Rudolf Zechner, Günter Haemmerle, Robert Zimmermann, Achim Lass
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 10, Pp 1972-1984 (2015)
Lipid droplets (LDs) of hepatic stellate cells (HSCs) contain large amounts of vitamin A [in the form of retinyl esters (REs)] as well as other neutral lipids such as TGs. During times of insufficient vitamin A availability, RE stores are mobilized t
Externí odkaz:
https://doaj.org/article/f2498427d99c463ab0fcfcdd48aab53a
Autor:
Stephanie Kolleritsch, Laura Pajed, Anna Tilp, Victoria Hois, Isabella Pototschnig, Benedikt Kien, Clemens Diwoky, Gerald Hoefler, Gabriele Schoiswohl, Guenter Haemmerle
Publikováno v:
Journal of Biological Chemistry. 299:104788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229177df949ec681e65b9e4d0860963e
https://doi.org/10.1016/j.jbc.2023.104788
https://doi.org/10.1016/j.jbc.2023.104788
Autor:
Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Cancer-associated cachexia (CAC) is a wasting syndrome drastically reducing efficacy of chemotherapy and life expectancy of patients. CAC affects up to 80% of cancer patients, yet the mechanisms underlying the disease are not well understood and no a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177efa78c2db845878e571d3b2594cd2
https://pubmed.ncbi.nlm.nih.gov/36351437
https://pubmed.ncbi.nlm.nih.gov/36351437
Autor:
Carina Wagner, Victoria Hois, Annalena Eggeling, Lisa-Maria Pusch, Laura Pajed, Patrick Starlinger, Thierry Claudel, Michael Trauner, Robert Zimmermann, Ulrike Taschler, Achim Lass
Publikováno v:
Journal of lipid research. 63(3)
Large quantities of vitamin A are stored as retinyl esters (REs) in specialized liver cells, the hepatic stellate cells (HSCs). To date, the enzymes controlling RE degradation in HSCs are poorly understood. In this study, we identified KIAA1363 (also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570c1f81c421b3f98061068d1a06ca26
https://pubmed.ncbi.nlm.nih.gov/35101424
https://pubmed.ncbi.nlm.nih.gov/35101424