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MHC class I molecules act as tumor suppressor genes regulating the cell cycle gene expression, invasion and intrinsic tumorigenicity of melanoma cells

Autor: Angel M. Garcia-Lora, Laura Paco, Irene Romero, Julia Stefansky, Enrique Berruguilla, Ignacio Algarra, Federico Garrido, Cristina Garrido, Antonia Collado

Publikováno v: Carcinogenesis. 33:687-693

The alteration of MHC class I (MHC-I) expression is a frequent event during cancer progression, allowing tumor cells to evade the immune system. We report that the loss of one major histocompatibility complex haplotype in human melanoma cells not onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5500925dbb23f839476ede3027fe53d3
https://doi.org/10.1093/carcin/bgr318

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Total loss of HLA class I expression on a melanoma cell line after growth in nude mice in absence of autologous antitumor immune response

Autor: Ignacio Algarra, Federico Garrido, Laura Paco, Angel M. Garcia-Lora, Miguel A. López-Nevot, C. Cabrera, Antonia Collado, Isabel Maleno, Carlos Casares

Publikováno v: International Journal of Cancer. 121:2023-2030

Loss of HLA class I expression on tumor cells is a frequent event as an immune escape mechanism. Seven different altered HLA phenotypes have been defined in tumors. Various molecular mechanisms have been described as responsible for HLA class I loss.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4599e2922970c36b8e4ca034dba9dd99
https://doi.org/10.1002/ijc.22925

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LOH at 6p21.3 region and HLA class altered phenotypes in bladder carcinomas

Autor: Teresa Cabrera, Laura Paco, José María Romero, Miguel A. López-Nevot, Miguel Tallada, Natalia Aptsiauri, Isabel Maleno, Jose Manuel Cozar, Federico Garrido

Publikováno v: Immunogenetics. 58:503-510

Alterations in HLA class I antigen expression have been frequently described in different epithelial tumors and are thought to favor tumor immune escape from T lymphocyte recognition. Multiple molecular mechanisms are responsible for these altered HL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4594769ad4fe9f536e13ffe7ffb2e5f1
https://doi.org/10.1007/s00251-006-0111-8

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A Functional Polymorphism of the NFKB1 Promoter Is Not Associated with Ulcerative Colitis in a Spanish Population

Autor: Leopoldo L. Martin, Francisco Correro, Laura Paco, Javier Martín, Alexis Piñero, Antonio Nieto, José A Brieva, Javier Oliver, María Gómez-García, Miguel A. López-Nevot

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Background: This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis. Methods: We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f948e022aa31e2fdc5782ab104594d4
https://doi.org/10.1097/01.mib.0000161916.20007.76

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Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus

Autor: Juan Jiménez-Alonso, José Luis Callejas, M F González-Escribano, Norberto Ortego-Centeno, Carmen Hidalgo, Elena Sánchez, Laura Paco, Miguel A. López-Nevot, Julio Sánchez-Román, J. Martín, Belén Torres, S. Morales, Miguel A. González-Gay

Publikováno v: Rheumatology. 44:1136-1139

OBJECTIVE The aim of this study was to assess the possible association between the interleukin-12B (IL12B) and interleukin-12 receptor beta 1 (IL12RB1) gene polymorphisms with systemic lupus erythematosus (SLE). In addition, we have undertaken a syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe9208f58699e047a5e001148a20702
https://doi.org/10.1093/rheumatology/keh697

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Analysis of the functional NFKB1 promoter polymorphism in rheumatoid arthritis and systemic lupus erythematosus

Autor: A. García, Miguel A. López-Nevot, Elena Sánchez, Laura Paco, Juan Jiménez-Alonso, Javier Martín, Gisela Orozco, Maria Dolores Collado

Publikováno v: Tissue Antigens. 65:183-186

Nuclear factor (NF)-kappaB plays an important role in inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A functional insertion/deletion polymorphism (-94ins/delATTG) has been identified in the promoter of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f36c528551e682bbdbaab7bb6ed91a
https://doi.org/10.1111/j.1399-0039.2005.00341.x

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Human leukocyte antigen-DQB1 and -DRB1 associations in patients with idiopathic sudden sensorineural hearing loss from a defined population of Northwest Spain

Autor: Laura Paco, Juan Carlos Amor-Dorado, Javier Martín, Miguel A. González-Gay, Miguel A. López-Nevot

Publikováno v: Acta Oto-Laryngologica. 125:1277-1282

The results of this study support the assertion that Southern European individuals have a genetically mediated predisposition to develop idiopathic sudden sensorineural hearing loss (SNHL).To assess the influence of human leukocyte antigen (HLA)-DQB1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c285aa70a344f4182fd109a7a98dbf64
https://doi.org/10.1080/00016480510012228

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High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity

Autor: Steven G.E. Marsh, Miguel Angel Lopez Nevot, Francisco Ruiz-Cabello, Isabel Maleno, Laura Paco, Teresa Rodríguez, Graham Pawelec, Rosa Mendez, Chrissy h. Roberts, Federico Garrido, I. Anthony Dodi

Publikováno v: Cancer Immunology, Immunotherapy. 54:141-148

Malignant transformation of cells is frequently associated with abnormalities in human leukocyte antigen (HLA) expression. MHC class I loss or down-regulation in cancer cells is a major immune escape route used by a large variety of human tumours to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f74dc30ebf857278f812714e280eda
https://doi.org/10.1007/s00262-004-0561-5

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A functional variant of IFNγ gene is associated with coeliac disease

Autor: Elena Urcelay, Javier Martin, A Mas-Fontao, Miguel A. López-Nevot, E Ortega, Laura Paco, E. Gómez de la Concha, Bo R. Rueda, Miguel Fernández-Arquero, Alfonso Martínez

Publikováno v: Genes & Immunity. 5:517-519

In coeliac disease (CD) a profile of proinflammatory cytokines are secreted interferon gamma (IFNgamma) being one of the most important. A dinucleotide polymorphism consisting of a variable number of CA repeats related with IFNgamma production levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6139ce1e02430e3bc2d3e59fe7383ceb
https://doi.org/10.1038/sj.gene.6364115

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A new extract of the plant calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation

Autor: Eva Jiménez-Medina, Angel M. Garcia-Lora, Antonia Collado, Laura Paco, Federico Garrido, Ignacio Algarra

Publikováno v: BMC Cancer
BMC Cancer, Vol 6, Iss 1, p 119 (2006)
Digibug. Repositorio Institucional de la Universidad de Granada
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Background Phytopharmacological studies of different Calendula extracts have shown anti-inflamatory, anti-viral and anti-genotoxic properties of therapeutic interest. In this study, we evaluated the in vitro cytotoxic anti-tumor and immunomodulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6f8eb67a099749b197d63d4e274c3a
http://hdl.handle.net/10481/29164

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