Výsledky vyhledávání - "Laura, Mazilescu"

Akademický článek

Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract We previously reported that normothermic ex vivo kidney perfusion (NEVKP) is superior in terms of organ protection compared to static cold storage (SCS), which is still the standard method of organ preservation, but the mechanisms are incomp

Externí odkaz: https://doaj.org/article/fde2c23c7d5e46e7ac674eec4e0b9a26

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Akademický článek

Prolonged warm ischemia time leads to severe renal dysfunction of donation-after-cardiac death kidney grafts

Autor: Peter Urbanellis, Laura Mazilescu, Dagmar Kollmann, Ivan Linares-Cervantes, J. Moritz Kaths, Sujani Ganesh, Fabiola Oquendo, Manraj Sharma, Toru Goto, Yuki Noguchi, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, Lisa A. Robinson, Markus Selzner

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Kidney transplantation with grafts procured after donation-after-cardiac death (DCD) has led to an increase in incidence of delayed graft function (DGF). It is thought that the warm ischemic (WI) insult encountered during DCD procurement is

Externí odkaz: https://doaj.org/article/a7173aed0e084c24a0ec74188dd02156

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Akademický článek

Transcriptome Analysis of Kidney Grafts Subjected to Normothermic Ex Vivo Perfusion Demonstrates an Enrichment of Mitochondrial Metabolism Genes

Autor: Peter Urbanellis, MD, PhD,, Caitriona M. McEvoy, MD, PhD, Marko Škrtić, MD, PhD, J. Moritz Kaths, MD,, Dagmar Kollmann, MD, PhD, Ivan Linares, MD, PhD, Sujani Ganesh, MSc, Fabiola Oquendo, MD, Manraj Sharma, BSc (Hons), Laura Mazilescu, MD, Toru Goto, MD, Yuki Noguchi, MD, PhD, Rohan John, MD, Istvan Mucsi, MD, PhD, Anand Ghanekar, MD, PhD, Darius Bagli, MD, Ana Konvalinka, MD, PhD, Markus Selzner, MD, Lisa A. Robinson, MD

Publikováno v: Transplantation Direct, Vol 7, Iss 8, p e719 (2021)

Background. Normothermic ex vivo kidney perfusion (NEVKP) has demonstrated superior outcomes for donation-after-cardiovascular death grafts compared with static cold storage (SCS). To determine the mechanisms responsible for this, we performed an unb

Externí odkaz: https://doaj.org/article/d110c16741be4afcab2dde2ba45f0981

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Akademický článek

Significant Dysfunction of Kidney Grafts Exposed to Prolonged Warm Ischemia Is Minimized Through Normothermic Ex Vivo Kidney Perfusion

Autor: Peter Urbanellis, MD, MSc, Dagmar Kollmann, MD, PhD, Ivan Linares, MD, PhD, Sujani Ganesh, MSc, Fabiola Oquendo, MD, Laura Mazilescu, MD, Toru Goto, MD, Yuki Noguchi, MD, PhD, Rohan John, MD, Ana Konvalinka, MD, PhD, Istvan Mucsi, MD, PhD, Anand Ghanekar, MD, PhD, Darius Bagli, MD, Markus Selzner, MD, Lisa A. Robinson, MD

Publikováno v: Transplantation Direct, Vol 6, Iss 8, p e587 (2020)

Background. Normothermic ex vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could improve early function of severely injured grafts and reduce the incidence of significant renal dysfu

Externí odkaz: https://doaj.org/article/7829d14e40974b15b2d595af4f526e29

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Akademický článek

Impact of Different Clinical Perfusates During Normothermic Ex Situ Liver Perfusion on Pig Liver Transplant Outcomes in a DCD Model

Autor: Ivan Linares-Cervantes, MD, Dagmar Kollmann, MD, PhD, Toru Goto, MD, Juan Echeverri, MD, Johan Moritz Kaths, MD, Matyas Hamar, MD, Peter Urbanellis, MD, Laura Mazilescu, MD, Roizar Rosales, MD, Claudia Bruguera, MD, Fabiola Oquendo, MD, Sujani Ganesh, Oyedele A. Adeyi, MD, Paul Yip, PhD, Nazia Selzner, MD, PhD, Markus Selzner, MD

Publikováno v: Transplantation Direct, Vol 5, Iss 4, p e437 (2019)

Background. Human albumin/dextran (HA-D), bovine-gelatin (BG), and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex situ liver perfusion (NEsLP). We compared the effects of these perf

Externí odkaz: https://doaj.org/article/8f95ab9aef4a4dc4b5da6037682b12ec

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Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

Autor: Catherine, Parmentier, Samrat, Ray, Laura, Mazilescu, Masataka, Kawamura, Yuki, Noguchi, Emmanuel, Nogueira, Sujani, Ganesh, Bhranavi, Arulratnam, Sangeetha, Kalimuthu, Markus, Selzner, Trevor, Reichman

Publikováno v: Journal of visualized experiments : JoVE. (185)

Pancreas transplantation (PTx) is a curative treatment for people who live with the burden of a diagnosis of diabetes mellitus (DM). However, due to organ shortages and increasing numbers of patients being listed for PTx, new strategies are needed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c437999119e3a58638546b7013a19d69
https://pubmed.ncbi.nlm.nih.gov/35969078

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Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Autor: Samrat, Ray, Catherine, Parmentier, Laura, Mazilescu, Masataka, Kawamura, Yuki, Noguchi, Emmanuel, Nogueira, Sujani, Ganesh, Bhranavi, Arulratnam, Markus, Selzner, Trevor, Reichman

Publikováno v: Journal of Visualized Experiments.

Despite the promising results of pancreas transplantation in type 1 diabetes mellitus and metabolic syndrome, the biggest concern around this state-of-the-art technique remains the paucity of organs deemed fit for transplantation. High intravascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fb7a88c22b13b8885023ac1e051e50
https://doi.org/10.3791/64203

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Normothermic Ex Situ Liver Perfusion Enhances Mitochondrial Function of DCD Grafts as Evidenced by High-throughput Metabolomics

Autor: Yuki Noguchi, Mamatha Bhat, Peter Urbanellis, Markus Selzner, Laura Mazilescu, Elisa Pasini, Nazia Selzner, Toru Goto, Preya Patel, Ivan Linares-Cervantes

Publikováno v: Transplantation. 105:1530-1538

Background Normothermic ex situ liver perfusion (NEsLP) reduces reperfusion injury of donation after circulatory death (DCD) grafts and optimizes graft function. The goal of our study was to elucidate how NEsLP impacts global metabolism in DCD grafts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aa0d5cf190c1ac0939b198fce452aa
https://doi.org/10.1097/tp.0000000000003476

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