A Comprehensive Genomic Analysis of the Emergent Klebsiella pneumoniae ST16 Lineage: Virulence, Antimicrobial Resistance and a Comparison with the Clinically Relevant ST11 Strain

Autor: Romário Oliveira de Sales, Laura Leaden, Letícia Busato Migliorini, Patricia Severino

Publikováno v: Pathogens, Vol 11, Iss 12, p 1394 (2022)

Klebsiella pneumoniae is considered an opportunistic pathogen frequently involved with healthcare-associated infections. The genome of K. pneumoniae is versatile, harbors diverse virulence factors and easily acquires and exchanges resistance plasmids

Externí odkaz: https://doaj.org/article/f8e2dd6adc394387b963a6b3f12bb35f

Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in Arabidopsis.

Autor: Valeria R Turowski, Cindy Aknin, Maria V Maliandi, Celeste Buchensky, Laura Leaden, Diego A Peralta, Maria V Busi, Alejandro Araya, Diego F Gomez-Casati

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0141443 (2015)

Frataxin plays a key role in eukaryotic cellular iron metabolism, particularly in mitochondrial heme and iron-sulfur (Fe-S) cluster biosynthesis. However, its precise role has yet to be elucidated. In this work, we studied the subcellular localizatio

Externí odkaz: https://doaj.org/article/1d2ddb4bf86d4bdcbaa933f9b6ae75f1

Iron Deficiency Generates Oxidative Stress and Activation of the SOS Response in Caulobacter crescentus

Autor: Rodolfo A. Ribeiro, Mariane Leichsenring Schulz, Larissa G. Silva, Naara M. dos Santos, Alan P. R. Lorenzetti, Marisa Helena Gennari de Medeiros, Laura Leaden, Tie Koide, Marilis V. Marques, Thiago Geronimo Pires Alegria

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Microbiology, Vol 9 (2018)

In C. crescentus, iron metabolism is mainly controlled by the transcription factor Fur (ferric uptake regulator). Iron-bound Fur represses genes related to iron uptake and can directly activate the expression of genes for iron-containing proteins. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0a0ffdaaaeae326fa654db195a3987
https://doi.org/10.3389/fmicb.2018.02014

The mitochondrial proteins AtHscB and AtIsu1 involved in Fe–S cluster assembly interact with the Hsp70-type chaperon AtHscA2 and modulate its catalytic activity

Autor: Laura Leaden, Maria V. Busi, Diego F. Gomez-Casati

Publikováno v: Mitochondrion. 19:375-381

Arabidopsis plants contain two genes coding for mitochondrial Hsp70-type chaperon-like proteins, AtHscA1 (At4g37910) and AtHscA2 (At5g09590). Both genes are homologs of the Ssq1 gene involved in Fe–S cluster assembly in yeast. Protein–protein int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70892151396b8b94771c55d45e613153
https://doi.org/10.1016/j.mito.2014.11.002

The mitochondrial protein frataxin is essential for heme biosynthesis in plants

Autor: Alejandro Araya, Maria Victoria Maliandi, Valeria R. Turowski, Maria V. Busi, Diego F. Gomez-Casati, Laura Leaden

Publikováno v: FEBS Journal. 278:470-481

Frataxin, a conserved mitochondrial protein implicated in cellular iron homeostasis, has been involved as the iron chaperone that delivers iron for the Fe-S cluster and heme biosynthesis. However, its role in iron metabolism remains unclear, especial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c830d72247227b14c95166d7a2114bea
https://doi.org/10.1111/j.1742-4658.2010.07968.x