Výsledky vyhledávání - "Laura, Iturrino"

Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

Autor: Hartmuth C. Kolb, Stijn Wuyts, Cindy Wintmolders, Leenaerts Joseph Elisabeth, Astrid Bottelbergs, Lieven Declercq, Fengbin Song, Paula te Riele, Chunfang A. Xia, Laura Iturrino, Frederik J. R. Rombouts, José-Ignacio Andrés, Diederik Moechars, Jonas Mariën, Lu Chen, Guy Bormans, Rik Vandenberghe

Publikováno v: Journal of Medicinal Chemistry. 62:2974-2987

In Alzheimer’s disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure–activity relationship exploration around an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::686efa9b68450d4f1fd527db59acb24c
https://doi.org/10.1021/acs.jmedchem.8b01759

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Discovery of N-(4-[

Autor: Frederik J R, Rombouts, Lieven, Declercq, José-Ignacio, Andrés, Astrid, Bottelbergs, Lu, Chen, Laura, Iturrino, Joseph E, Leenaerts, Jonas, Mariën, Fengbin, Song, Cindy, Wintmolders, Stijn, Wuyts, Chunfang A, Xia, Paula, Te Riele, Guy, Bormans, Rik, Vandenberghe, Hartmuth, Kolb, Diederik, Moechars

Publikováno v: Journal of medicinal chemistry. 62(6)

In Alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04ed37a4764f6110413f18c159611c77
https://pubmed.ncbi.nlm.nih.gov/32069047

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Automated open-access liquid chromatography high resolution mass spectrometry to support drug discovery projects

Autor: Alberto Fontana, Antonio L. Crego, Laura Iturrino, David Corens

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 178:112908

The need of a continuous productivity increases in medicinal chemistry laboratories of the pharmaceutical industry motivated the development, over the years, of new software solutions to enable Open-Access in many analytical techniques such as NMR or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a1a01f8230da2b2d421b0efe84176f
https://doi.org/10.1016/j.jpba.2019.112908

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Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia

Autor: José Manuel Bartolomé-Nebreda, Marijke Somers, Laura Iturrino, Greet Vanhoof, Joaquín Pastor, Susana Conde-Ceide, María Luz Martín-Martín, Xavier Langlois, Gregor James Macdonald, Anton Megens, Francisca Delgado, Wendy Sanderson, Carlos M. Martínez-Viturro, Han Min Tong

Publikováno v: Journal of Medicinal Chemistry. 57:4196-4212

We report the discovery of a series of imidazo[1,2-a]pyrazine derivatives as novel inhibitors of phosphodiesterase 10A (PDE10A). In a high-throughput screening campaign we identified the imidazopyrazine derivative 1, a PDE10A inhibitor with limited s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ac9ae359ff0523ce350342854294aa
https://doi.org/10.1021/jm500073h

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Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Autor: Hilde Lavreysen, Andrés A. Trabanco, Jesús Alcázar, Sofie Celen, Meri De Angelis, Guy Bormans, Xavier Langlois, José María Cid, Laura Iturrino, José-Ignacio Andrés

Publikováno v: Journal of Medicinal Chemistry. 55:8685-8699

The synthesis and in vitro and in vivo evaluation of a new series of 7-(phenylpiperidinyl)-1,2,4-triazolo[4,3-a]pyridines, which were conveniently radiolabeled with carbon-11, as potential positron emission tomography (PET) radiotracers for in vivo i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56e1181a89e450a4105cedd6138c963
https://doi.org/10.1021/jm300912k

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Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging

Autor: Meri De Angelis, Jesús Alcázar, Greet Vanhoof, Stefanie Dedeurwaerdere, Laura Iturrino, Xavier Langlois, José-Ignacio Andrés, Guy Bormans, Ilse Lenaerts, Sofie Celen

Publikováno v: Journal of Medicinal Chemistry. 54:5820-5835

We have recently reported the phosphodiesterase 10A (PDE10A) inhibitor 2-[4-[1-(2-[(18)F]fluoroethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-phenoxymethyl]-quinoline ([(18)F]1a) as a promising candidate for in vivo imaging using positron emission tomography

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b756bc3211ee11c3ec9dd57f32b1e7f6
https://doi.org/10.1021/jm200536d

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4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective δ-opioid agonists

Autor: Andrés A. Trabanco, Rosa M. Alvarez, Frans Eduard Janssens, Thomas Steckler, Inge Boeckx, Theo F. Meert, Laura Iturrino, Leenaerts Joseph Elisabeth, Antonio Gómez, Encarna Matesanz, Shirley Pullan, Ana Isabel de Lucas, Javier Fernández, J. Alonso, José Ignacio Andrés

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:146-149

A novel series of 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives has been prepared and their synthesis described herein. In vitro affinities for delta-, mu-, and kappa-opioid receptors, as well as the functional activity in the [(35)S]GTPgammaS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31562021226af97121a5638ab8fd8193
https://doi.org/10.1016/j.bmcl.2005.09.025

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