A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Autor: Emilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire, Mirian Fernández-Vaquero, Tobias Riedl, Xiaochen Sun, Hadassa Hirschfield, Frank Jühling, Shijia Zhu, Natascha Roehlen, Clara Ponsolles, Laura Heydmann, Antonio Saviano, Tongqi Qian, Anu Venkatesh, Joachim Lupberger, Eloi R. Verrier, Mozhdeh Sojoodi, Marine A. Oudot, François H. T. Duong, Ricard Masia, Lan Wei, Christine Thumann, Sarah C. Durand, Victor González-Motos, Danijela Heide, Jenny Hetzer, Shigeki Nakagawa, Atsushi Ono, Won-Min Song, Takaaki Higashi, Roberto Sanchez, Rosa S. Kim, C. Billie Bian, Karun Kiani, Tom Croonenborghs, Aravind Subramanian, Raymond T. Chung, Beate K. Straub, Detlef Schuppan, Maliki Ankavay, Laurence Cocquerel, Evelyne Schaeffer, Nicolas Goossens, Anna P. Koh, Milind Mahajan, Venugopalan D. Nair, Ganesh Gunasekaran, Myron E. Schwartz, Nabeel Bardeesy, Alex K. Shalek, Orit Rozenblatt-Rosen, Aviv Regev, Emanuele Felli, Patrick Pessaux, Kenneth K. Tanabe, Mathias Heikenwälder, Catherine Schuster, Nathalie Pochet, Mirjam B. Zeisel, Bryan C. Fuchs, Yujin Hoshida, Thomas F. Baumert

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine

Externí odkaz: https://doaj.org/article/454d7d31ae1e40b7812cd73b90a2e7e3

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

Autor: Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating

Publikováno v: iScience, Vol 24, Iss 10, Pp 103144- (2021)

Summary: The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the re

Externí odkaz: https://doaj.org/article/9e863295d0ed4df8a498ce0d3e971ee4

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Autor: Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos, Bryan C. Fuchs, Yujin Hoshida, Maike Hofmann, Mogens Vyberg, Birgitte Martine Viuff, Elisabeth D. Galsgaard, Greg Elson, Alberto Toso, Markus Meyer, Roberto Iacone, Tamas Schweighoffer, Geoffrey Teixeira, Solange Moll, Claudio De Vito, Tania Roskams, Irwin Davidson, Danijela Heide, Mathias Heikenwälder, Mirjam B. Zeisel, Joachim Lupberger, Laurent Mailly, Catherine Schuster, Thomas F. Baumert

Publikováno v: Roehlen, N, Saviano, A, El Saghire, H, Crouchet, E, Nehme, Z, Del Zompo, F, Jühling, F, Oudot, M A, Durand, S C, Duong, F H T, Cherradi, S, Gonzalez Motos, V, Almeida, N, Ponsolles, C, Heydmann, L, Ostyn, T, Lallement, A, Pessaux, P, Felli, E, Cavalli, A, Sgrignani, J, Thumann, C, Koutsopoulos, O, Fuchs, B C, Hoshida, Y, Hofmann, M, Vyberg, M, Viuff, B M, Galsgaard, E D, Elson, G, Toso, A, Meyer, M, Iacone, R, Schweighoffer, T, Teixeira, G, Moll, S, De Vito, C, Roskams, T, Davidson, I, Heide, D, Heikenwälder, M, Zeisel, M B, Lupberger, J, Mailly, L, Schuster, C & Baumert, T F 2022, ' A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity ', Science Translational Medicine, vol. 14, no. 676, eabj4221, pp. eabj4221 . https://doi.org/10.1126/scitranslmed.abj4221

Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the tight junct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15761706f515b3e02c2102683616d7
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9

[Hepatitis C virus and neutralizing antibodies]

Autor: Catherine, Fauvelle, Laura, Heydmann, Mirjam B, Zeisel, Thomas F, Baumert, Françoise, Stoll-Keller, Samira, Fafi-Kremer

Publikováno v: Virologie (Montrouge, France). 15(5)

Neutralizing antibodies represent a key component of immune control in many viral infections. For a long time, these antibodies were thought to play a marginal role in hepatitis C virus (HCV) infection, and that cellular immune responses are more cri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::801b7d10c7a54ccea110d2bb43ef4ce3
https://pubmed.ncbi.nlm.nih.gov/36151691

Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection

Autor: Françoise Stoll-Keller, Thomas F. Baumert, Laura Heydmann, Isabel Fofana, Quentin Lepiller, Daniel J. Felmlee, Samira Fafi-Kremer, Mirjam B. Zeisel, Catherine Fauvelle

Publikováno v: Viruses, Vol 4, Iss 10, Pp 2016-2030 (2012)

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutraliz

Externí odkaz: https://doaj.org/article/267d9f52d872420f96efdfb5d1d2168e