Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control

Autor: Lee Davidson, Laura Francis, Ross A. Cordiner, Joshua D. Eaton, Chris Estell, Sara Macias, Javier F. Cáceres, Steven West

Publikováno v: Cell Reports, Vol 26, Iss 10, Pp 2779-2791.e5 (2019)

Summary: Cell-based studies of human ribonucleases traditionally rely on methods that deplete proteins slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess

Externí odkaz: https://doaj.org/article/d371ae4c1a99434ea1385794f47c8f8f

Practitioner research

Autor: Christine Parker, Laura Francis, Lisa Yung, Laura Stinson, Angela Dean

Publikováno v: Studying for an Early Childhood Degree ISBN: 9781003271727

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::337fd4a3f936d9f36f7378db80f622af
https://doi.org/10.4324/9781003271727-5

Impact of Plasma Protein Binding in Drug Clearance Prediction: A Data Base Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation

Autor: Houston Jb, Laura Francis, David Hallifax

Publikováno v: Drug Metabolism and Disposition. 49:188-201

Plasma protein-mediated uptake (PMU) and its effect on clearance (CL) prediction have been studied in various formats; however, a comprehensive analysis of the overall impact of PMU on CL parameters from hepatocyte assays (routinely used for IVIVE) h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af5b43d36b0418606c84b0dad8547d1
https://doi.org/10.1124/dmd.120.000294

'Pause-2-Play': a pilot schoolbased obesity prevention program 'Pause-2-Play': um programa piloto escolar de prevenção de obesidade

Autor: Gregory Killough, Danielle Battram, Joanne Kurtz, Gillian Mandich, Laura Francis, Meizi He

Publikováno v: Revista Brasileira de Saúde Materno Infantil, Vol 10, Iss 3, Pp 303-311 (2010)

OBJECTIVES: "Pause-2-Play" is an obesity prevention program targeting screen-related sedentary behaviours and increasing physical activity among elementary school students. The program consisted of a Behavioural Modification Curriculum and a Health P

Externí odkaz: https://doaj.org/article/942aec0bdb7c4054acb283359153609b

Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC MS/MS analysis: An investigatory study with imipramine

Autor: David Hallifax, Laura Francis, Andrew W Harrell, Aleksandra Galetin

Publikováno v: Francis, L, Harrell, A, Hallifax, D & Galetin, A 2020, ' Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC MS/MS analysis: An investigatory study with imipramine ', Journal of Pharmaceutical Sciences, vol. 109, no. 9, pp. 2891-2901 . https://doi.org/10.1016/j.xphs.2020.05.026

Lysosomes are acidic intracellular organelles that can extensively sequester basic lipophilic drugs due to pH and membrane partitioning, and therefore may significantly influence subcellular drug concentrations. Current in vitro methods for lysosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc6eb3b0c30ce116072f617c2f872a7
https://www.research.manchester.ac.uk/portal/en/publications/utilising-magnetically-isolated-lysosomes-for-direct-quantification-of-intralysosomal-drug-concentrations-by-lc-msms-analysis-an-investigatory-study-with-imipramine(cf0e99ed-82e3-43a4-b4d8-4454c9626c22).html