Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Laura, Conforti"'
Autor:
Ameet A. Chimote, Abdulaziz O. Alshwimi, Martina Chirra, Vaibhavkumar S. Gawali, Margaret V. Powers-Fletcher, Kristin M. Hudock, Laura Conforti
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 is characterized by cytokine storm, an excessive production of proinflammatory cytokines that contributes to acute lung damage and death. Dexamethasone is routinely used to treat severe COVID-19 and has been shown to reduc
Externí odkaz:
https://doaj.org/article/66e2924b6b58480db9a76dfa664afe6a
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 133-143 (2021)
In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8+ T cell functions including chemotaxis and tumor infiltration. Adenosin
Externí odkaz:
https://doaj.org/article/93994cde84c24784907ef9ef889ddc9c
Autor:
Vaibhavkumar S. Gawali, Ameet A. Chimote, Hannah S. Newton, Manuel G. Feria-Garzón, Martina Chirra, Edith M. Janssen, Trisha M. Wise-Draper, Laura Conforti
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca2+ fluxes, and thereby T cell effector functio
Externí odkaz:
https://doaj.org/article/3988e8398cf542708e8c547c9f888c29
Autor:
Laura Conforti, Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is an immunotherapy agent currently approved for metastatic HNSCC and curati
Externí odkaz:
https://doaj.org/article/65aba8cacdf74f5d84b824a04f706c53
Autor:
Laura Conforti, Laura Agresta, Maria Lehn, Kristin Lampe, Rachel Cantrell, Cassandra Hennies, Sara Szabo, Trisha Wise-Draper, Kasper Hoebe, Edith M Janssen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Developing novel strategies to overcome the immunosuppressive tumor microenvironment is a critically important area of cancer therapy research. Here, we assess the therapeutic potential of CD244 (2B4/signaling lymphocyte activation molecul
Externí odkaz:
https://doaj.org/article/399509727da14162bd5e3fe439ed4134
Autor:
Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these proteins led to the ide
Externí odkaz:
https://doaj.org/article/b3991ff6c7554f1da5eaf0b9425b3a69
Autor:
Ameet A. Chimote, Vaibhavkumar S. Gawali, Hannah S. Newton, Trisha M. Wise-Draper, Laura Conforti
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T
Externí odkaz:
https://doaj.org/article/6de5d9af9a4947339b10f27bd2a1fae0
Autor:
Qassim Dirar, Teal Russell, Lumei Liu, Sarah Ahn, Gianpietro Dotti, Shyam Aravamudhan, Laura Conforti, Yeoheung Yun
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238819 (2020)
Adoptive cell transfer of Chimeric Antigen Receptor (CAR)-T cells showed promising results in patients with B cell malignancies. However, the detailed mechanism of CAR-T cell interaction with the target tumor cells is still not well understood. This
Externí odkaz:
https://doaj.org/article/6b80e12b69b74198a52290865f893f2b
Autor:
Laura Conforti, Keith A. Casper, Trisha Wise-Draper, Brittany N. Gleich, Alexandros M. Sfyris, Peter Hajdu, Ameet A. Chimote
Histopathology analysis of Hematoxylin-Eosin stained slides from HNC tumor and normal tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593b9f92c5673a0796ee300421a2c1ce
https://doi.org/10.1158/0008-5472.22412333.v1
https://doi.org/10.1158/0008-5472.22412333.v1
Autor:
Laura Conforti, Keith A. Casper, Trisha Wise-Draper, Brittany N. Gleich, Alexandros M. Sfyris, Peter Hajdu, Ameet A. Chimote
Quantitation of Kv1.3 protein expression in CD8+ TIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280263fab638db6d8e591cb41ee0ae3c
https://doi.org/10.1158/0008-5472.22412345
https://doi.org/10.1158/0008-5472.22412345