Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

Autor: Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop

Publikováno v: eLife, Vol 12 (2023)

Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To

Externí odkaz: https://doaj.org/article/d7b516710de643d58647394ef7678b1a

New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10

Autor: Laura Campello, Oksana Kutsyr, Agustina Noailles, Patrycja Michalska, Laura Fernández-Sánchez, Natalia Martínez-Gil, Isabel Ortuño-Lizarán, Xavier Sánchez-Sáez, Emilio de Juan, Pedro Lax, Rafael León, Antonio G. García, Nicolás Cuenca, Victoria Maneu

Publikováno v: Cellular Physiology and Biochemistry, Vol 54, Iss 1, Pp 142-159 (2020)

Externí odkaz: https://doaj.org/article/fd1c141c1f6741f0bb2aba5c80669253

The Absence of Toll-Like Receptor 4 Mildly Affects the Structure and Function in the Adult Mouse Retina

Autor: Agustina Noailles, Oksana Kutsyr, Victoria Maneu, Isabel Ortuño-Lizarán, Laura Campello, Emilio de Juan, Violeta Gómez-Vicente, Nicolás Cuenca, Pedro Lax

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

The innate immune Toll-like receptor (TLR) family plays essential roles in cell proliferation, survival and function of the central nervous system. However, the way in which TLRs contribute to the development and maintenance of proper retinal structu

Externí odkaz: https://doaj.org/article/7c0eb7dc9c0f4bb9baa71c66645f3594

Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions

Autor: Anupam Kumar Mondal, Anand Swaroop, Ximena Corso-Díaz, Jayshree Advani, Laura Campello, Nivedita Singh

Publikováno v: Annual Review of Vision Science. 7:633-664

Multifaceted and divergent manifestations across tissues and cell types have curtailed advances in deciphering the cellular events that accompany advanced age and contribute to morbidities and mortalities. Increase in human lifespan during the past c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ce5810b166970219bc75167a2ed6d8
https://doi.org/10.1146/annurev-vision-100419-114940

Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids

Autor: Ananya Samanta, James Gentry, Kamil Kruczek, Zepeng Qu, Benjamin R. Fadl, Brian P. Brooks, Colin J Chu, Zhijian Wu, Zachary Batz, Linn Gieser, Laura Campello, Suja Hiriyanna, Anand Swaroop, Mugdha Samant

Publikováno v: Stem Cell Reports
Kruczek, K, Qu, Z, Gentry, J, Fadl, B R, Gieser, L, Hiriyanna, S, Batz, Z, Samant, M, Samanta, A, Chu, C J, Campello, L, Brooks, B P, Wu, Z & Swaroop, A 2021, ' Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids ', Stem Cell Reports, vol. 16, no. 2, pp. 252-263 . https://doi.org/10.1016/j.stemcr.2020.12.018

Summary Mutations in the photoreceptor transcription factor gene cone-rod homeobox (CRX) lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Using induced pluripotent stem cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0a53897ea69bd6cee97b109036be2
https://doi.org/10.1016/j.stemcr.2020.12.018