Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura, Brohée"'
Autor:
Laura Brohée, Olivier Peulen, Betty Nusgens, Vincent Castronovo, Marc Thiry, Alain C. Colige, Christophe F. Deroanne
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Propranolol, a widely used non-selective beta-adrenergic receptor blocker, was recently shown to display anticancer properties. Its potential to synergize with certain drugs has been also outlined. However, it is necessary to take into accou
Externí odkaz:
https://doaj.org/article/76f47ad4a6c14361aa10363a8d4226c1
Autor:
Céline Hendricks, Johanne Dubail, Laura Brohée, Yves Delforge, Alain Colige, Christophe Deroanne
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165153 (2016)
Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and plexins/semaphorins. It is involved in axonal development, angiogenesis and cancer progression
Externí odkaz:
https://doaj.org/article/abc3ba1ae57741789629974f05bf0f3a
Autor:
Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A. Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A. Teleman, Claudio De Virgilio, Constantinos Demetriades
Publikováno v:
bioRxiv
Cell growth is regulated primarily by the mammalian/mechanistic Target of Rapamycin Complex 1 (mTORC1) that functions both as a nutrient sensor and a master controller of virtually all biosynthetic pathways 1. This ensures that cells are metabolicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3985f50d8f0a3632dc14dc7fad8bf361
Autor:
Katharina Fitzian, Claudia Antoni, Stephanie Beel, Anna Livia Linard Matos, Andrea Oeckinghaus, Sabine Wilhelm, Laura Brohée, Volker Gerke, Daniel Kümmel, Constantinos Demetriades, Stephan Kiontke, Reinhard Zech, Christian Ungermann, Mark Nellist, Anne Brückner, Stefan Raunser, Raphael Gasper
Publikováno v:
Mol Cell
Molecular cell 81(13), 2705-2721.e8 (2021). doi:10.1016/j.molcel.2021.04.019
Molecular Cell, 81(13), 2705-2721.e8. Cell Press
Molecular cell 81(13), 2705-2721.e8 (2021). doi:10.1016/j.molcel.2021.04.019
Molecular Cell, 81(13), 2705-2721.e8. Cell Press
Molecular cell 81(13), 2705 - 2721.e8 (2021). doi:10.1016/j.molcel.2021.04.019
The TSC complex is a critical negative regulator of the small GTPase Rheb and mTORC1 in cellular stress signaling. The TSC2 subunit contains a catalytic GTPase activa
The TSC complex is a critical negative regulator of the small GTPase Rheb and mTORC1 in cellular stress signaling. The TSC2 subunit contains a catalytic GTPase activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fb22ee6c6cdbeb33964f3d482b883a
https://hdl.handle.net/21.11116/0000-000A-B789-D
https://hdl.handle.net/21.11116/0000-000A-B789-D
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4419, p 4419 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The rewiring of lipid metabolism is a major adaptation observed in cancer, and it is generally associated with the increased aggressiveness of cancer cells. Targeting lipid metabolism is therefore an appealing therapeutic strategy, but it requires a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419f8572c8f9769a6e091529723bab5b
https://www.mdpi.com/1422-0067/22/9/4419
https://www.mdpi.com/1422-0067/22/9/4419
Autor:
Christiane A. Opitz, Ulrike Rehbein, Laura Brohée, Aurelio A. Teleman, Alexander Martin Heberle, Constantinos Demetriades, Marti Cadena Sandoval, Wilhelm Palm, Jose Miguel Ramos Pittol, Matylda Macias, Saskia Trump, Katharina Kern, Bianca Berdel, Andreas von Deimling, Birgit Holzwarth, Bernadette Carroll, Ines Heiland, Ann-Sofie De Meulemeester, Mirja Tamara Prentzell, Aleksandra Siekierska, Kathrin Thedieck, Jacek Jaworski, Mark Nellist, Hannah West, Mariana E. G. de Araujo, Mathias Bockwoldt, Eduard Stefan, Friederike Reuter, Michèle Reil, Andrii Kopach, Sandra Woltering, Suvagata Roy Chowdhury, Stefan Pusch, Viktor I. Korolchuk, Ralf Baumeister, Magdalena Kedra, Justyna Zmorzynska, Julian R. Sampson, Teodor E. Yordanov, Ineke van 't Land-Kuper, Chloë Scheldeman, Omar Torres-Quesada, Anja Reintjes, Lukas A. Huber, Gianluca Figlia, Peter de Witte, Laura E. Thomas
Publikováno v:
Cell
2021, ' G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling ', Cell, vol. 184, no. 3, pp. 655-674.e27 . https://doi.org/10.1016/j.cell.2020.12.024
Cell, 184(3), 655-674.e27. Cell Press
Cell, 184(3), 655-674.e27. CELL PRESS
2021, ' G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling ', Cell, vol. 184, no. 3, pp. 655-674.e27 . https://doi.org/10.1016/j.cell.2020.12.024
Cell, 184(3), 655-674.e27. Cell Press
Cell, 184(3), 655-674.e27. CELL PRESS
Summary Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1988cff1d6a25e654c51d5e842f355
https://hdl.handle.net/10037/21857
https://hdl.handle.net/10037/21857
Autor:
Christiane A. Opitz, Ulrike Rehbein, van ’t Land-Kuper I, Aurelio A. Teleman, Marti Cadena Sandoval, von Deimling A, Constantinos Demetriades, Teodor E. Yordanov, Viktor I. Korolchuk, Katharina Kern, Alexander Martin Heberle, Reil M, Mirja Tamara Prentzell, Ines Heiland, Gianluca Figlia, Saskia Trump, De Wildeman Stefaan M A, Chloë Scheldeman, Ralf Baumeister, Mark Nellist, Omar Torres-Quesada, de Witte P, Kathrin Thedieck, Bianca Berdel, Matylda Macias, Kopach A, Birgit Holzwarth, Eduard Stefan, Stefan Pusch, Laura Brohée, Bernadette Carroll, Anja Reintjes, Lukas A. Huber, Mathias Bockwoldt, Jacek Jaworski, Friederike Reuter
SummaryG3BP1 (Ras GTPase-activating protein-binding protein 1) is widely recognized as a core component of stress granules (SG), non-membranous RNA-protein-assemblies required for cellular survival under stress. We report that in the absence of SG, G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0333ed62d2649dd431f13773bf1cda16
Autor:
Christophe Deroanne, Marc Thiry, Betty Nusgens, Laura Brohée, Alain Colige, Vincent Castronovo, Olivier Peulen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Propranolol, a widely used non-selective beta-adrenergic receptor blocker, was recently shown to display anticancer properties. Its potential to synergize with certain drugs has been also outlined. However, it is necessary to take into account all th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ada559f55f20d3728129d34737bbae7
https://doaj.org/article/76f47ad4a6c14361aa10363a8d4226c1
https://doaj.org/article/76f47ad4a6c14361aa10363a8d4226c1
Autor:
Christophe Deroanne, Alain Colige, Jérôme Willems, Stéphane Demine, Laura Brohée, Thierry Arnould
Publikováno v:
Oncotarget
Brohée, L, Demine, S, Willems, J, Arnould, T, Colige, A C & Deroanne, C F 2015, ' Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment ', Oncotarget, vol. 6, no. 13, pp. 11264-11280 .
Brohée, L, Demine, S, Willems, J, Arnould, T, Colige, A C & Deroanne, C F 2015, ' Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment ', Oncotarget, vol. 6, no. 13, pp. 11264-11280 .
Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc4206620da0c4b57f20e4cf498a696
http://europepmc.org/articles/PMC4484455
http://europepmc.org/articles/PMC4484455
Autor:
Gilles, Rademaker, Vincent, Hennequière, Laura, Brohée, Marie-Julie, Nokin, Pierre, Lovinfosse, Florence, Durieux, Stéphanie, Gofflot, Justine, Bellier, Brunella, Costanza, Michael, Herfs, Raphael, Peiffer, Lucien, Bettendorff, Christophe, Deroanne, Marc, Thiry, Philippe, Delvenne, Roland, Hustinx, Akeila, Bellahcène, Vincent, Castronovo, Olivier, Peulen
Publikováno v:
Oncogene
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death. Therapeutic options remain very limited and are based on classical chemotherapies. Energy metabolism reprogramming appears as an emerging hallmark of cancer a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c496ee65a00f7847be97dbe10d906043
https://pubmed.ncbi.nlm.nih.gov/29720728
https://pubmed.ncbi.nlm.nih.gov/29720728