Výsledky vyhledávání - "Laurène Ramos Martins"

Akademický článek

Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Autor: Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit

Externí odkaz: https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b

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SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning

Autor: Rolf Zeller, Julie Gamart, Robert Reinhardt, Thomas Oberholzer, Frédéric Laurent, Aimée Zuniga, Iros Barozzi, Laurène Ramos Martins, Axel Visel

Publikováno v: Development (Cambridge, England), vol 148, iss 23
Development (Cambridge, England)
article-version (VoR) Version of Record
Development

SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its target genes have remained largely elusive. Here, we identify the SMAD4 target genes in mouse limb buds usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d676506e583373e9d8e92abd208b1c5
https://escholarship.org/uc/item/47k5k30b

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SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning

Autor: Laurène Ramos Martins, Thomas Oberholzer, Axel Visel, Julie Gamart, Robert Reinhardt, Iros Barozzi, Frédéric Laurent, Aimée Zuniga, Rolf Zeller

SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction and is required for diverse morphogenetic processes, but its target genes have remained largely elusive. Here, we use an epitope-tagged Smad4 allele for ChIP-seq analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7489015bf8b9bdfd75b9e680146596d
https://doi.org/10.1101/2021.09.08.459466

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Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Autor: Robert Reinhardt, Jonas Malkmus, Javier Lopez-Rios, Bonnie K. Kircher, Koh Onimaru, Amandine Duchesne, Rushikesh Sheth, Francisca Leal, Shalu Jhanwar, Aimée Zuniga, Laurène Ramos Martins, Kevin A. Peterson, Rolf Zeller, Victorio Palacio, Martin J. Cohn

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 2021, 12 (1), pp.5557. ⟨10.1038/s41467-021-25810-1⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

Precise cis-regulatory control of gene expression is essential for normal embryogenesis and tissue development. The BMP antagonist Gremlin1 (Grem1) is a key node in the signalling system that coordinately controls limb bud development. Here, we use m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4438eb101874ed1d0bc64f6879901920

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