Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

Autor: Aymeric Silvin, Stefan Uderhardt, Cecile Piot, Sandro Da Mesquita, Katharine Yang, Laufey Geirsdottir, Kevin Mulder, David Eyal, Zhaoyuan Liu, Cecile Bridlance, Morgane Sonia Thion, Xiao Meng Zhang, Wan Ting Kong, Marc Deloger, Vasco Fontes, Assaf Weiner, Rachel Ee, Regine Dress, Jing Wen Hang, Akhila Balachander, Svetoslav Chakarov, Benoit Malleret, Garett Dunsmore, Olivier Cexus, Jinmiao Chen, Sonia Garel, Charles Antoine Dutertre, Ido Amit, Jonathan Kipnis, Florent Ginhoux

Publikováno v: Immunity
Immunity, 2022, 55 (8), pp.1448-1465.e6. ⟨10.1016/j.immuni.2022.07.004⟩

Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain development and homeostasis but are also implicated in aging pathogenesis and neurodegenerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6cd5de183a756c6d4c1de42ccc6cbf
https://pubmed.ncbi.nlm.nih.gov/35931085

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo

Autor: Sethuraman Subramanian, Clara Jana-Lui Busch, Kaaweh Molawi, Laufey Geirsdottir, Julien Maurizio, Stephanie Vargas Aguilar, Hassiba Belahbib, Gregory Gimenez, Ridzky Anis Advent Yuda, Michaela Burkon, Jérémy Favret, Sara Gholamhosseinian Najjar, Bérengère de Laval, Prashanth Kumar Kandalla, Sandrine Sarrazin, Lena Alexopoulou, Michael H. Sieweke

Publikováno v: Nature Immunology
Nature Immunology, 2022, 23 (3), pp.458-468. ⟨10.1038/s41590-022-01146-w⟩

International audience; Alveolar macrophages (AMs) are lung tissue-resident macrophages that can be expanded in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show that mouse long-term ex vivo expanded AMs (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9195762cba8fd07d7415320e3ac39693
https://tud.qucosa.de/id/qucosa:78399

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

Autor: Kerstin Mätz-Rensing, Charles-Antoine Dutertre, Stefan Cornelius Bohlen, Finnbogi Rutur Thormodsson, Ido Amit, Hadas Keren-Shaul, Noga Zilkha, Stephan Meckel, Christine Pfeifle, Marco Prinz, Antonella Raffo-Romero, Igor Ulitsky, Christine Stadelmann, Eyal David, Christian Scheiwe, Jacopo Vizioli, Franziska van der Meer, Assaf Weiner, Daniel Erny, Adam Balic, Tali Kimchi, Amir Giladi, Florent Ginhoux, Jana Neuber, Francesca Peri, Laufey Geirsdottir, Fadi Sheban, Kaspar Matiasek

Publikováno v: Geirsdottir, L, David, E, Keren-Shaul, H, Weiner, A, Bohlen, S C, Neuber, J, Balic, A, Giladi, A, Sheban, F, Dutertre, C-A, Pfeifle, C, Peri, F, Raffo-Romero, A, Vizioli, J, Matiasek, K, Scheiwe, C, Meckel, S, Mätz-Rensing, K, van der Meer, F, Thormodsson, F R, Stadelmann, C, Zilkha, N, Kimchi, T, Ginhoux, F, Ulitsky, I, Erny, D, Amit, I & Prinz, M 2019, ' Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program ', Cell, vol. 179, no. 7, pp. 1609-1622.e16 . https://doi.org/10.1016/j.cell.2019.11.010
Cell
Cell, 2019, 179 (7), pp.1609-1622.e16. ⟨10.1016/j.cell.2019.11.010⟩
Cell, Elsevier, 2019, 179 (7), pp.1609-1622.e16. ⟨10.1016/j.cell.2019.11.010⟩

Erratum inCross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program.Geirsdottir L, David E, Keren-Shaul H, Weiner A, Bohlen SC, Neuber J, Balic A, Giladi A, Sheban F, Dutertre CA, Pfeifle C, Peri F, Raffo-Romero A, Viziol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce21fd4b3f6fe838ccd77431e46ec6f5
https://hdl.handle.net/20.500.11820/75599dad-e7df-4242-945e-697bfc355ade

Mapping microglia states in the human brain through the integration of high-dimensional techniques

Autor: Roman, Sankowski, Chotima, Böttcher, Takahiro, Masuda, Laufey, Geirsdottir, Sagar, Elena, Sindram, Tamara, Seredenina, Andreas, Muhs, Christian, Scheiwe, Mukesch Johannes, Shah, Dieter Henrik, Heiland, Oliver, Schnell, Dominic, Grün, Josef, Priller, Marco, Prinz

Publikováno v: Nature neuroscience. 22(12)

Microglia are tissue-resident macrophages of the CNS that orchestrate local immune responses and contribute to several neurological and psychiatric diseases. Little is known about human microglia and how they orchestrate their highly plastic, context

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51578ce45f07b19a2f7550c7d12ff352
https://pubmed.ncbi.nlm.nih.gov/35637374