NUDT2 initiates viral RNA degradation by removal of 5'-phosphates

Autor: Laudenbach, Beatrice T., Krey, Karsten, Emslander, Quirin, Andersen, Line Lykke, Reim, Alexander, Scaturro, Pietro, Mundigl, Sarah, Dächert, Christopher, Manske, Katrin, Moser, Markus, Ludwig, Janos, Wohlleber, Dirk, Kröger, Andrea, Binder, Marco, Pichlmair, Andreas

Publikováno v: Nature communications
England
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

While viral replication processes are largely understood, comparably little is known on cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5′-triphosphate (PPP-) group that impairs degradation by the canonical 5′-3′ degradation pat

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https://hdl.handle.net/10033/623151

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NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.

Autor: Laudenbach BT; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany.; Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Martinsried/Munich, Germany., Krey K; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany., Emslander Q; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany., Andersen LL; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany., Reim A; Department of Proteomics and Signal transduction, Max-Planck Institute of Biochemistry, Martinsried/Munich, Germany., Scaturro P; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany.; Leibniz Institute for Experimental Virology (HPI), Hamburg, Germany., Mundigl S; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany., Dächert C; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response' (division F170), German Cancer Research Center, Heidelberg (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Manske K; Technical University of Munich, School of Medicine, Institute of Molecular Immunology, Munich, Germany., Moser M; Department of Molecular Medicine, Max-Planck Institute of Biochemistry, Martinsried/Munich, Germany.; Technical University of Munich, School of Medicine, Institute of Experimental Hematology, Munich, Germany., Ludwig J; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Wohlleber D; Technical University of Munich, School of Medicine, Institute of Molecular Immunology, Munich, Germany., Kröger A; Otto von Guericke University Magdeburg, Institute for Medical Microbiology, Magdeburg, Germany.; Helmholtz Centre for Infection Research, Innate Immunity and Infection, Braunschweig, Germany., Binder M; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response' (division F170), German Cancer Research Center, Heidelberg (DKFZ), Heidelberg, Germany., Pichlmair A; Technical University of Munich, School of Medicine, Institute of Virology, 81675, Munich, Germany. andreas.pichlmair@tum.de.; Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Martinsried/Munich, Germany. andreas.pichlmair@tum.de.; German Center for Infection Research (DZIF), Munich partner site, Munich, Germany. andreas.pichlmair@tum.de.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 25; Vol. 12 (1), pp. 6918. Date of Electronic Publication: 2021 Nov 25.