Safety and Biodistribution Profile of Poly(styrenyl acetal trehalose) and Its Granulocyte Colony Stimulating Factor Conjugate.

Autor: Ko JH; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Forsythe NL; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Gelb MB; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Messina KMM; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Lau UY; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Bhattacharya A; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Olafsen T; Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1569, United States., Lee JT; Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1569, United States., Kelly KA; Department of Pathology and Lab Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1569, United States., Maynard HD; Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.

Publikováno v: Biomacromolecules [Biomacromolecules] 2022 Aug 08; Vol. 23 (8), pp. 3383-3395. Date of Electronic Publication: 2022 Jun 29.

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2.

Autor: Linsky TW; Neoleukin Therapeutics Inc., Seattle, WA, USA., Vergara R; Neoleukin Therapeutics Inc., Seattle, WA, USA., Codina N; Neoleukin Therapeutics Inc., Seattle, WA, USA., Nelson JW; Neoleukin Therapeutics Inc., Seattle, WA, USA., Walker MJ; Neoleukin Therapeutics Inc., Seattle, WA, USA., Su W; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China., Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Hsiang TY; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA., Esser-Nobis K; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA., Yu K; Neoleukin Therapeutics Inc., Seattle, WA, USA., Reneer ZB; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA., Hou YJ; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA., Priya T; Neoleukin Therapeutics Inc., Seattle, WA, USA., Mitsumoto M; Neoleukin Therapeutics Inc., Seattle, WA, USA., Pong A; Neoleukin Therapeutics Inc., Seattle, WA, USA., Lau UY; Neoleukin Therapeutics Inc., Seattle, WA, USA., Mason ML; Neoleukin Therapeutics Inc., Seattle, WA, USA., Chen J; Neoleukin Therapeutics Inc., Seattle, WA, USA., Chen A; Neoleukin Therapeutics Inc., Seattle, WA, USA., Berrocal T; Neoleukin Therapeutics Inc., Seattle, WA, USA., Peng H; Neoleukin Therapeutics Inc., Seattle, WA, USA., Clairmont NS; Neoleukin Therapeutics Inc., Seattle, WA, USA., Castellanos J; Neoleukin Therapeutics Inc., Seattle, WA, USA., Lin YR; Neoleukin Therapeutics Inc., Seattle, WA, USA., Josephson-Day A; Neoleukin Therapeutics Inc., Seattle, WA, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fuller DH; Department of Microbiology, University of Washington, Seattle, WA, USA., Walkey CD; Neoleukin Therapeutics Inc., Seattle, WA, USA., Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.; Department of Infectious Diseases, University of Georgia, Athens, GA, USA., Swanson R; Neoleukin Therapeutics Inc., Seattle, WA, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Gale M Jr; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA., Blancas-Mejia LM; Neoleukin Therapeutics Inc., Seattle, WA, USA., Yen HL; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China., Silva DA; Neoleukin Therapeutics Inc., Seattle, WA, USA. dadriano@neoleukin.com.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Dec 04; Vol. 370 (6521), pp. 1208-1214. Date of Electronic Publication: 2020 Nov 05.

PEG Analogs Synthesized by Ring-Opening Metathesis Polymerization for Reversible Bioconjugation.

Autor: Pelegri-O'Day EM; Department of Chemistry and Biochemistry and California Nanosystems Institute , University of California, Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095-1569 , United States., Matsumoto NM; Department of Chemistry and Biochemistry and California Nanosystems Institute , University of California, Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095-1569 , United States., Tamshen K; Department of Chemistry and Biochemistry and California Nanosystems Institute , University of California, Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095-1569 , United States., Raftery ED; Department of Chemistry and Biochemistry and California Nanosystems Institute , University of California, Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095-1569 , United States., Lau UY; Department of Bioengineering , University of California, Los Angeles , 410 Westwood Plaza , Los Angeles , California 90095 , United States., Maynard HD; Department of Chemistry and Biochemistry and California Nanosystems Institute , University of California, Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095-1569 , United States.; Department of Bioengineering , University of California, Los Angeles , 410 Westwood Plaza , Los Angeles , California 90095 , United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2018 Nov 21; Vol. 29 (11), pp. 3739-3745. Date of Electronic Publication: 2018 Oct 25.

Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization.

Autor: Lau UY; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA., Pelegri-O'Day EM; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA, 90095, USA., Maynard HD; Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, CA, 90095, USA.; Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA, 90095, USA.

Publikováno v: Macromolecular rapid communications [Macromol Rapid Commun] 2018 Mar; Vol. 39 (5). Date of Electronic Publication: 2017 Dec 18.

Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography.

Autor: Bat E; 1] Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA [2] California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, USA., Lee J; 1] Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA [2] California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, USA., Lau UY; 1] California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, USA [2] Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, California 90095, USA., Maynard HD; 1] Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA [2] California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, USA [3] Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, California 90095, USA.

Publikováno v: Nature communications [Nat Commun] 2015 Mar 20; Vol. 6, pp. 6654. Date of Electronic Publication: 2015 Mar 20.