Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

Autor: Grootveld, AK, Kyaw, W, Panova, V, Lau, AWY, Ashwin, E, Seuzaret, G, Dhenni, R, Bhattacharyya, ND, Khoo, WH, Biro, M, Mitra, T, Meyer-Hermann, M, Bertolino, P, Tanaka, M, Hume, DA, Croucher, PI, Brink, R, Nguyen, A, Bannard, O, Phan, TG

Publikováno v: Cell. 186:1144-1161.e18

Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e8ece1063f6f8b6d2b7585ea489387
https://doi.org/10.1016/j.cell.2023.02.004

Positive selection of IgG ⁺ over IgM ⁺ B cells in the germinal center reaction.

Autor: Sundling C; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; Division of Infectious Diseases and Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, 17176 Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, 17176 Stockholm, Sweden., Lau AWY; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia., Bourne K; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Young C; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia., Laurianto C; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia., Hermes JR; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Menzies RJ; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Butt D; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Kräutler NJ; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia., Zahra D; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia., Suan D; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia., Brink R; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia. Electronic address: r.brink@garvan.org.au.

Publikováno v: Immunity [Immunity] 2021 May 11; Vol. 54 (5), pp. 988-1001.e5. Date of Electronic Publication: 2021 Apr 14.