A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency

Autor: Poole, Emma L., Kew, Verity G., Lau, Jonathan C.H., Murray, Matthew J., Stamminger, Thomas, Sinclair, John H., Reeves, Matthew B.

Publikováno v: In Cell Reports 17 July 2018 24(3):594-606

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

Autor: Hertweck, Arnulf, Evans, Catherine M., Eskandarpour, Malihe, Lau, Jonathan C.H., Oleinika, Kristine, Jackson, Ian, Kelly, Audrey, Ambrose, John, Adamson, Peter, Cousins, David J., Lavender, Paul, Calder, Virginia L., Lord, Graham M., Jenner, Richard G.

Publikováno v: Hertweck, A, Evans, CM, Eskandarpour, M, Lau, JC H, Oleinika, K, Jackson, I, Kelly, A, Ambrose, J, Adamson, P, Cousins, DJ, Lavender, P, Calder, VL, Lord, GM & Jenner, RG 2016, ' T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex ', Cell Reports, vol. 15, no. 12, pp. 2756–2770 . https://doi.org/10.1016/j.celrep.2016.05.054
Cell Reports, Vol 15, Iss 12, Pp 2756-2770 (2016)
Hertweck, A, Evans, C M, Eskandarpour, M, Lau, J C H, Oleinika, K, Jackson, I, Kelly, A, Ambrose, J, Adamson, P, Cousins, D J, Lavender, P, Calder, V L, Lord, G M & Jenner, R G 2016, ' T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex ', Cell Reports, vol. 15, no. 12, pp. 2756-2770 . https://doi.org/10.1016/j.celrep.2016.05.054

The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment

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