Endogenous retrotransposons cause catastrophic deoxyribonucleic acid damage in human trophoblasts.

Autor: Mauro M; Department of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Medical Center, New York, New York; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York., Wei S; Department of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Medical Center, New York, New York., Breborowicz A; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York., Li X; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York., Bognanni C; The Rockefeller University, Howard Hughes Medical Institute, and Laboratory of RNA Molecular Biology, New York, New York., Fuller Z; Department of Biological Sciences, Columbia University, New York, New York., Philipp T; Institute of Clinical Gynecology and Obstetrics, Danube Hospital, Vienna, Austria., McDonald T; Department of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Medical Center, New York, New York., Lattin MT; Department of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Medical Center, New York, New York., Williams Z; Department of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Medical Center, New York, New York. Electronic address: zw2421@cumc.columbia.edu.

Publikováno v: F&S science [F S Sci] 2023 Aug; Vol. 4 (3), pp. 200-210. Date of Electronic Publication: 2023 May 22.

Cross-sectional analysis reveals autoantibody signatures associated with COVID-19 severity.

Autor: Baiocchi GC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Vojdani A; Immunosciences Laboratory, Inc., Department of Immunology, Los Angeles, California, USA.; Cyrex Laboratories, Phoenix, Arizona, USA., Rosenberg AZ; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA., Vojdani E; Regenera Medical, Los Angeles, California, USA., Halpert G; Ariel University, Ariel, Israel.; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Saint Petersburg State University Russia, St Petersburg, Russia., Ostrinski Y; Ariel University, Ariel, Israel.; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Saint Petersburg State University Russia, St Petersburg, Russia., Zyskind I; Department of Pediatrics, NYU Langone Medical Center, New York, New York, USA.; Maimonides Medical Center, Brooklyn, New York, USA., Filgueiras IS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Schimke LF; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Marques AHC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Giil LM; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway., Lavi YB; Department of Chemistry Ben Gurion University Beer-Sheva, Beer-Sheva, Israel., Silverberg JI; Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, USA., Zimmerman J; Maimonides Medical Center, Brooklyn, New York, USA., Hill DA; ResourcePath, Sterling, Virginia, USA., Thornton A; ResourcePath, Sterling, Virginia, USA., Kim M; Data Science Initiative at Brown University, Providence, Rhode Island, USA., De Vito R; Department of Biostatistics and the Data Science Initiative at Brown University, Providence, Rhode Island, USA., Fonseca DLM; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil., Plaça DR; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, São Paulo, Brazil., Freire PP; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Camara NOS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Calich VLG; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Scheibenbogen C; Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany., Heidecke H; CellTrend Gesellschaft mit beschränkter Haftung (GmbH), Luckenwalde, Germany., Lattin MT; Department of Biology, Yeshiva University, Manhatten, New York, USA., Ochs HD; Department of Pediatrics, University of Washington School of Medicine, and Seattle Children's Research Institute, Seattle, Washington, USA., Riemekasten G; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany., Amital H; Ariel University, Ariel, Israel.; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Shoenfeld Y; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Saint Petersburg State University Russia, St Petersburg, Russia., Cabral-Marques O; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, São Paulo, Brazil.; Department of Pharmacy and Postgraduate Program of Health and Science, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine, Baltimore, USA.; Laboratory of Medical Investigation 29, University of São Paulo School of Medicine, São Paulo, Brazil.

Publikováno v: Journal of medical virology [J Med Virol] 2023 Feb; Vol. 95 (2), pp. e28538.

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.

Autor: Cabral-Marques O; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Network of Immunity in Infection, Malignancy, and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sao Paulo, Brazil. otavio.cmarques@usp.br., Halpert G; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Saint Petersburg State University, Saint-Petersburg, Russia., Schimke LF; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Ostrinski Y; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Saint Petersburg State University, Saint-Petersburg, Russia.; Ariel University, Ariel, Israel., Vojdani A; Department of Immunology, Immunosciences Laboratory, Inc., Los Angeles, CA, United States.; Cyrex Laboratories, LLC 2602S. 24th St., Phoenix, AZ, 85034, USA., Baiocchi GC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Freire PP; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Filgueiras IS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Zyskind I; Department of Pediatrics, NYU Langone Medical Center, New York, NY, USA.; Maimonides Medical Center, Brooklyn, NY, USA., Lattin MT; Department of Biology, Yeshiva University, Manhatten, NY, USA., Tran F; Department of Internal Medicine I, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany., Schreiber S; Department of Internal Medicine I, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany., Marques AHC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Plaça DR; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Fonseca DLM; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil., Humrich JY; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany., Müller A; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany., Giil LM; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway., Graßhoff H; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany., Schumann A; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany., Hackel A; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany., Junker J; CellTrend Gesellschaft mit beschränkter Haftung (GmbH), Luckenwalde, Germany., Meyer C; CellTrend Gesellschaft mit beschränkter Haftung (GmbH), Luckenwalde, Germany., Ochs HD; Department of Pediatrics, University of Washington School of Medicine, and Seattle Children's Research Institute, Seattle, WA, USA., Lavi YB; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Scheibenbogen C; Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Dechend R; Experimental and Clinical Research Center, a collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin, and HELIOS Clinic, Department of Cardiology and Nephrology, Berlin, 13125, Germany., Jurisica I; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, UHN; Data Science Discovery Centre, Krembil Research Institute, UHN, Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Canada.; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia., Schulze-Forster K; CellTrend Gesellschaft mit beschränkter Haftung (GmbH), Luckenwalde, Germany., Silverberg JI; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA., Amital H; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel., Zimmerman J; Maimonides Medical Center, Brooklyn, NY, USA., Heidecke H; CellTrend Gesellschaft mit beschränkter Haftung (GmbH), Luckenwalde, Germany., Rosenberg AZ; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Riemekasten G; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck, Lübeck, Germany. gabriela.riemekasten@uksh.de., Shoenfeld Y; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel. shoenfel@post.tau.ac.il.; Saint Petersburg State University, Saint-Petersburg, Russia. shoenfel@post.tau.ac.il.; Ariel University, Ariel, Israel. shoenfel@post.tau.ac.il.

Publikováno v: Nature communications [Nat Commun] 2022 Mar 09; Vol. 13 (1), pp. 1220. Date of Electronic Publication: 2022 Mar 09.