Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors

Autor: Anastasiya Zaytseva, Evelina Bouckova, McKennon J Wiles, Madison H Wustrau, Isabella G Schmidt, Hadassah Mendez-Vazquez, Latika Khatri, Seonil Kim

Publikováno v: eLife, Vol 12 (2023)

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is presumed to underlie its rapid antidepressant effects. Moreover, ketamine’s therapeutic actions are likely mediated by enhancing neuronal Ca2+ signaling. Howev

Externí odkaz: https://doaj.org/article/f16086eb8b2a479b97bf9c1b0698567f

Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor

Autor: Mariela Mitre, Khalil Saadipour, Kevin Williams, Latika Khatri, Robert C. Froemke, Moses V. Chao

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Brain-derived Neurotrophic Factor (BDNF) binds to the TrkB tyrosine kinase receptor, which dictates the sensitivity of neurons to BDNF. A unique feature of TrkB is the ability to be activated by small molecules in a process called transactivation. He

Externí odkaz: https://doaj.org/article/01492600aa0f409f8f890261727a14f9

Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery

Autor: Robert Froemke, Ismail Ahmed, Jingjing Liu, Krystyna Gieniec, Chloe Bair-Marshall, Ayomiposi Adewakun, Belinda Hetzler, Christopher Arp, Latika Khatri, Gilles Vanwalleghem, Alec Seidenberg, Pamela Cowin, Dirk Trauner, Moses Chao, Felicity Davis, Richard Tsien

Oxytocin is a neuropeptide critical for maternal physiology and social behavior, and is thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and neurocognitive importance of oxytocin signaling, methods are lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c8e1014eb5b057596f8437303d9d077
https://doi.org/10.21203/rs.3.rs-2715993/v1

Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery

Autor: Ismail A. Ahmed, Jing-Jing Liu, Krystyna A. Gieniec, Chloe J. Bair-Marshall, Ayomiposi B. Adewakun, Belinda E. Hetzler, Christopher J. Arp, Latika Khatri, Gilles C. Vanwalleghem, Alec T. Seidenberg, Pamela Cowin, Dirk Trauner, Moses V. Chao, Felicity M. Davis, Richard W. Tsien, Robert C. Froemke

Publikováno v: Ahmed, I A, Liu, J-J, Gieniec, K A, Bair-Marshall, C J, Adewakun, A B, Hetzler, B E, Arp, C J, Khatri, L, Vanwalleghem, G C, Seidenberg, A T, Cowin, P, Trauner, D, Chao, M V, Davis, F M, Tsien, R W & Froemke, R C 2022, ' Optopharmacological tools for precise spatiotemporal control of oxytocin signaling in the central nervous system and periphery ', bioRxiv . https://doi.org/10.1101/2022.11.10.516001

Oxytocin is a neuropeptide critical for maternal physiology and social behavior, and is thought to be dysregulated in several neuropsychiatric disorders. Despite the biological and neurocognitive importance of oxytocin signaling, methods are lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0a6861deeb949ce47fc03514083ca2
https://pure.au.dk/portal/da/publications/optopharmacological-tools-for-precise-spatiotemporal-control-of-oxytocin-signaling-in-the-central-nervous-system-and-periphery(d2feb2a8-e9b0-4e22-ad93-fdadae6a0bd7).html

Confronting the Loss of Trophic Support

Autor: Hui-Lan Hu, Latika Khatri, Marilyn Santacruz, Emily Church, Christopher Moore, Tony T. Huang, Moses Victor Chao

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44cfe28fee20921da60b62f6940233dc
https://doi.org/10.2139/ssrn.4298233