In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics

Autor: Fatima Ezzahra Bennani, Khalid Karrouchi, Latifa Doudach, Mario Scrima, Noor Rahman, Luca Rastrelli, Trina Ekawati Tallei, Christopher E. Rudd, My El Abbes Faouzi, M’hammed Ansar

Publikováno v: Current Issues in Molecular Biology, Vol 44, Iss 11, Pp 5312-5351 (2022)

Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern. Multiple drug resistance has also emerged in

Externí odkaz: https://doaj.org/article/6e1daa3dfa014fd2ab03d3109669e8a1

Mineral and Phenolic Composition of Erodium guttatum Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice

Autor: Kaoutar Benrahou, Hanae Naceiri Mrabti, Saad Fettach, Mohamed Reda Kachmar, Mostafa Kouach, Jean-François Goossens, Latifa Doudach, Shafi Mahmud, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Abdelhakim Bouyahya, My El Abbes Faouzi

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, 2022, Oxidative Medicine and Cellular Longevity, 2022, pp.4229981. ⟨10.1155/2022/4229981⟩

Erodium guttatum is widely used in folk medicine in many countries to treat various ailments such as urinary inflammation, diabetes, constipation, and eczema. The aim of this study is the determination of mineral and phenolic compounds of E. guttatum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2661dd7b5d70fc9e3322d6433da131b0
https://doi.org/10.1155/2022/4229981

Phenolic content, antibacterial, antioxidant, and toxicological investigations of Erodium guttatum (Geraniaceae) collected from the Northeast of Morocco

Autor: Hanae NACEIRI MRABTI, Latifa DOUDACH, Mohamed Reda KACHMAR, Abdelaziz ED-DRA, Zineb KHALIL, Nidal NACEIRI MRABTI, Kaoutar BENRAHOU, Khouloud HARRAQUI, Gökhan ZENGİN, Abdelhakim BOUYAHYA, Moulay El Abbes FAOUZI

Publikováno v: TURKISH JOURNAL OF BOTANY. 45:739-749

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f91c91c318a936a131f7d86d263747e
https://doi.org/10.3906/bot-2107-29

Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study

Autor: Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Abdelilah Tarib, Christopher E Rudd, M’hammed Ansar, My El Abbes Faouzi

Publikováno v: Journal of biomolecular structuredynamics.

Cancer remains the leading cause of death in the world despite the significant advancements made in anticancer drug discovery. This study is aimed to computationally evaluate the efficacy of 63 in-house synthesized pyrazole derivatives targeted to bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46405fd8e3614c7fc133e93950427699
https://pubmed.ncbi.nlm.nih.gov/35442150

Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines

Autor: Fatima Ezzahra, Bennani, Latifa, Doudach, Khalid, Karrouchi, Youssef, El Rhayam, Christopher E, Rudd, M'hammed, Ansar, My, El Abbes Faouzi

Publikováno v: Heliyon. 8(8)

Despite the decades of scientific studies for developing promising new therapies, cancer remains a major cause of illness and mortality, worldwide. Several cancer types are the major topic of research in drug discovery programs due to their global in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::722c954d1bd58dd1da4d62af9dfb1896
https://pubmed.ncbi.nlm.nih.gov/35965973