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Baseline characteristics of Ghanaian children and adults enrolled in PIVOT, a randomised clinical trial of hydroxyurea in HbSC disease in sub-Saharan Africa.

Autor: Segbefia CI; Department of Child Health, University of Ghana Medical School, Accra, Ghana.; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Smart LR; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Stuber SE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Amissah-Arthur KN; Ophthalmology Unit, Department of Surgery, University of Ghana Medical School, Accra, Ghana.; Ophthalmology Unit, Department of Surgery, Korle Bu Teaching Hospital, Accra, Ghana., Dzefi-Tettey K; Department of Radiology, Korle Bu Teaching Hospital, Accra, Ghana.; Department of Radiology, University of Health and Allied Sciences, Ho, Ghana., Ekpale P; Pharmacy Department, Korle Bu Teaching Hospital, Accra, Ghana., Mensah E; Department of Haematology, University of Ghana Medical School, Accra, Ghana., Lane AC; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Ghunney W; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Tagoe LG; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Oteng A; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Amoako E; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Latham TS; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Dei-Adomakoh YA; Department of Haematology, University of Ghana Medical School, Accra, Ghana.; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana., Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Publikováno v: British journal of haematology [Br J Haematol] 2024 Dec; Vol. 205 (6), pp. 2470-2480. Date of Electronic Publication: 2024 Oct 15.

Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease.

Autor: Smart LR; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA. luke.smart@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA. luke.smart@cchmc.org.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, USA. luke.smart@cchmc.org., Segbefia CI; Department of Child Health, University of Ghana Medical School, Accra, Ghana.; Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana., Latham TS; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA., Stuber SE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, USA., Amissah-Arthur KN; Ophthalmology Unit, Department of Surgery, University of Ghana Medical School, Accra, Ghana.; Ophthalmology Unit, Department of Surgery, Korle Bu Teaching Hospital, Accra, Ghana., Dzefi-Tettey K; Department of Radiology, Korle Bu Teaching Hospital, Accra, Ghana., Lane AC; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA., Dei-Adomakoh YA; Department of Haematology, University of Ghana Medical School, Accra, Ghana.; Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana.; Ghana Institute of Clinical Genetics, Korle Bu, Accra, Ghana., Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

Publikováno v: Trials [Trials] 2023 Sep 22; Vol. 24 (1), pp. 603. Date of Electronic Publication: 2023 Sep 22.

Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.

Autor: Olupot-Olupot P; Mbale Clinical Research Institute, Mbale, Uganda.; Mbale Regional Referral and Teaching Hospital/Busitema University, Mbale, Uganda., Tomlinson G; Department of Medicine, University Health Network and Mt Sinai Hospital, Toronto, ON, Canada.; University of Toronto, Toronto, ON, Canada., Williams TN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Institute of Global Health Innovation, Imperial College, London, United Kingdom., Tshilolo L; Institut de Recherche Biomédicale in CEFA/Centre Hospitalier Monkole, Kinshasa, Democratic Republic of Congo., Santos B; Hospital Pediátrico David Bernardino, Luanda, Angola., Smart LR; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH.; University of Cincinnati College of Medicine, Cincinnati, OH.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., McElhinney K; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH., Howard TA; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH., Aygun B; Cohen Children's Medical Center, New Hyde Park, NY.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY., Stuber SE; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Lane A; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH.; University of Cincinnati College of Medicine, Cincinnati, OH., Latham TS; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH., Ware RE; Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH.; University of Cincinnati College of Medicine, Cincinnati, OH.; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publikováno v: Blood [Blood] 2023 Mar 23; Vol. 141 (12), pp. 1402-1410.

Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.

Autor: Meier ER; Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA., Creary SE; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH, USA.; Center for Innovation in Pediatric Practice, Nationwide Children's Hospital Research Institute, The Ohio State University, Columbus, OH, USA., Heeney MM; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Dong M; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Appiah-Kubi AO; Pediatric Hematology, Children's Hospitals and Clinics of Minnesota, Minneapolis and St. Paul, MN, USA., Nelson SC; Division of Hematology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH, 45229, USA., Niss O; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Piccone C; Case Western Reserve University School of Medicine, Department of Hematology and Oncology, University Hospitals Rainbow Babies and Children's, Cleveland, OH, USA., Quarmyne MO; Emory University School of Medicine & Sickle Cell Disease Program, Children's Healthcare of Atlanta, Atlanta, GA, USA., Quinn CT; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Saving KL; University of Illinois Peioria, Peoria, IL, USA., Scott JP; Medical College of Wisconsin, Milwaukee, WI, USA., Talati R; Cleveland Clinic, Cleveland, OH, USA., Latham TS; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Pfeiffer A; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Shook LM; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., Vinks AA; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Lane A; University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA., McGann PT; University of Cincinnati College of Medicine, Cincinnati, OH, USA. patrick.mcgann@cchmc.org.; Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children's Medical Center of New York, New Hyde Park, NY, USA. patrick.mcgann@cchmc.org.

Publikováno v: Trials [Trials] 2020 Nov 27; Vol. 21 (1), pp. 983. Date of Electronic Publication: 2020 Nov 27.