Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Latha, Periyasamy"'
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer
Autor:
Safiulla Basha Syed, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Latha Periyasamy, Hsing-Pang Hsieh, Mohane Selvaraj Coumar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract P-glycoprotein (P-gp) is a drug transporter that effluxes chemotherapeutic drugs and is implicated in the development of resistance of cancer cells to chemotherapeutic drugs. To date, no drug has been approved to inhibit P-gp and restore che
Externí odkaz:
https://doaj.org/article/8f1abc9fc04a4f1dbd447a375a78af9c
Publikováno v:
Letters in Applied Microbiology. 71:272-279
Impairment of antioxidant enzymes activities has been well reported in several human diseases. Effective anti-ageing strategies involving antioxidant supplementation and/or caloric restriction (CR) are receiving a great attention to mitigate free rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c766b55bb11bc217e87d31745ec2853
https://doi.org/10.1111/lam.13313
https://doi.org/10.1111/lam.13313
Autor:
V Stella Sravanthi, Dinakara Rao Ampasala, Rengarajan Venkatesan, Gnana vel, Bhagath Kumar Palaka, Latha Periyasamy
Publikováno v:
Process Biochemistry. 82:153-166
In the present study, we have modelled signal transducer and activator of transcription (STAT) 3 and STAT1 proteins using SWISS-MODEL server and refined by molecular dynamic simulations using GROMACS 5.1.2 software for 30 ns. Later, refined protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de89c37cfe94914cd35ba92addaa69e
https://doi.org/10.1016/j.procbio.2019.04.018
https://doi.org/10.1016/j.procbio.2019.04.018
Autor:
Dinesh Babu Jestadi, Alugoju Phaniendra, Undru Babji, Thupakula Srinu, Bhavatharini Shanmuganathan, Latha Periyasamy
Publikováno v:
Journal of Toxicology, Vol 2014 (2014)
The present study evaluates the effects of short term (15 days) exposure of low dose (300 μg kg−1) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabe
Externí odkaz:
https://doaj.org/article/04f7843b226b4ce1947eaa76a58013f9
Autor:
Sajid Abdul, Rub Pakkath, Shashank Shankar, Chetty, Praneetha, Selvarasu, Arumugam, Vadivel Murugan, Yogesh, Kumar, Latha, Periyasamy, Muthukamalam, Santhakumar, Sudha Rani, Sadras, Kirankumar, Santhakumar
Publikováno v:
ACS biomaterials scienceengineering. 4(7)
Heteroatom-doped carbon dots (C-dots) have captured widespread research interest owing to high fluorescence and biocompatibility for multimodal bioimaging applications. Here, we exemplify a rapid, facile synthesis of ethylenediamine (EDA)-functionali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ae65c6974ef1542d216de1c3ab54a89
https://pubmed.ncbi.nlm.nih.gov/33435121
https://pubmed.ncbi.nlm.nih.gov/33435121
Publikováno v:
Life sciences. 263
Background and Aim Aging is associated with oxidative stress and altered cholinergic and mitochondrial function. Crocin is a carotenoid antioxidant that quenches free radicals and protects cells and tissues from oxidation in biological systems. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385c7cfdbd084e533c88e1661b7284ee
https://pubmed.ncbi.nlm.nih.gov/33038382
https://pubmed.ncbi.nlm.nih.gov/33038382
Autor:
Shu Yu Lin, Mohane Selvaraj Coumar, Latha Periyasamy, Hemant Arya, Safiulla Basha Syed, Teng-Kuang Yeh, I-Hsuan Fu, Hsing Pang Hsieh, Mariasoosai Ramya Chandar Charles
Publikováno v:
Chemical biologydrug designREFERENCES. 97(1)
P-glycoprotein (P-gp)/MDR-1 plays a major role in the development of multidrug resistance (MDR) by pumping the chemotherapeutic drugs out of the cancer cells and reducing their efficacy. A number of P-gp inhibitors were reported to reverse the MDR wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141e3ef093c323e7cc66c314343386e
https://pubmed.ncbi.nlm.nih.gov/32633857
https://pubmed.ncbi.nlm.nih.gov/32633857
The decline in metabolic homeostasis over time leads to various physiological disorders. Disruption of this homeostasis results in hyperglycemia (elevated levels of glucose) and accumulation of free radicals, which subsequently favor pro-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845761b3430311ab223245eb04bbf041
https://doi.org/10.1016/b978-0-12-817903-1.00010-3
https://doi.org/10.1016/b978-0-12-817903-1.00010-3
Publikováno v:
Nutrition and Cancer. 70:971-983
Hepatocellular carcinoma (HCC) is the most common liver cancer and is known to be resistant to conventional chemotherapy. The use of herbal medicine and supplements has increased over recent decades following side effects and resistant to conventiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953c73e3ddf0962f8a2744597bfbaf0b
https://doi.org/10.1080/01635581.2018.1490445
https://doi.org/10.1080/01635581.2018.1490445
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 17:119-131
Background & Objective: Aging is characterized by gradual accumulation of macromolecular damage leading to progressive loss of physiological function and increased susceptibility to diverse diseases. Effective anti-aging strategies involving caloric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bf2ba45f63f0e8a8f254b26fd81441
https://doi.org/10.2174/1871527317666180314120507
https://doi.org/10.2174/1871527317666180314120507