Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Latent TGF-beta binding protein"'
Autor:
Tiong Yang Tan, Shan Zong, Jeremy L. Freeman, Daniel G. Calame, Xiaomin Dong, Ingrid E. Scheffer, Davide Vecchio, John Christodoulou, Marco Tartaglia, Francesca Clementina Radio, Nicole J Van Bergen, Susan M. White, Maria Piccione, Stefanie Eggers, Sabina Barresi, Natalie B Tan, Katherine B. Howell
Publikováno v:
Am J Hum Genet
Negative regulator of reactive oxygen species (NRROS) is a leucine-rich repeat-containing protein that uniquely associates with latent transforming growth factor beta-1 (TGF- β1) and anchors it on the cell surface; this anchoring is required for act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f153b2664ebef0465c2e922fcdb95e2f
https://doi.org/10.1016/j.ajhg.2020.02.014
https://doi.org/10.1016/j.ajhg.2020.02.014
Autor:
Simone Pizzi, Daniela Rogaia, Amedea Mencarelli, Giuseppe Merla, Maria Giovanna Tedesco, Valentina Imperatore, Alessandro Bruselles, Elisabetta Flex, Giuseppe Di Cara, Marco Tartaglia, Andrea Ciolfi, Stefania Troiani, Alberto Verrotti, Paolo Prontera, Giovanna Carpentieri
Publikováno v:
Genes, Vol 12, Iss 1406, p 1406 (2021)
In recent years, a rare form of autosomal recessive brachyolmia associated with amelogenesis imperfecta (AI) has been described as a novel nosologic entity. This disorder is characterized by skeletal dysplasia (e.g., platyspondyly, short trunk, scoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1476327de32abd776bcd30df6fe1086
https://www.mdpi.com/2073-4425/12/9/1406
https://www.mdpi.com/2073-4425/12/9/1406
Autor:
Liang Han, Bin Jiang, Ming ming Tang, Jianfeng Qiang, Xinjiang Xu, Xingmei Feng, Jianfei Huang
Publikováno v:
Oncotarget
Latent transforming growth factor (TGF)-beta binding protein 2 (LTBP2) belongs to the fibrillin/LTBP extracellular matrix glycoprotein superfamily. It plays vital roles in tumorigenesis through regulating TGFβ activity, elastogenesis and maintenance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a5c9ff029dbc762eaec47581e896d7
http://europepmc.org/articles/PMC5216705
http://europepmc.org/articles/PMC5216705
Autor:
Shigehiko Suzuki, Toshihiro Ishiko, Kenji Tomihata, Rino Aya, Tomoyuki Nakamura, Motoko Naitoh, Hiroshi Kubota, Satoko Yamawaki, Katsuhiro Yoshikawa, Yuki Sakamoto, Yasuhiro Katayama, Kazuo Noda
Publikováno v:
Biomaterials. 72:29-37
The objective of this study was to investigate the effects of latent TGF-β binding protein 4 (LTBP-4) on elastic fiber regeneration in three-dimensional cultures of human dermal fibroblasts (HDFs). Appropriate collagen scaffold for elastic fiber reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88641040dd4661e68b66bf698e1cc0ce
http://hdl.handle.net/2433/210507
http://hdl.handle.net/2433/210507
Autor:
Elizabeth M. McNally, Andy H. Vo
Publikováno v:
Current Opinion in Neurology. 28:528-534
Purpose of review Recently, genetic pathways that modify the clinical severity of Duchenne muscular dystrophy (DMD) have been identified. The pathways uncovered as modifiers are useful to predict prognosis and also elucidate molecular signatures that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0236c9844f004458c926f54faaed06bd
https://doi.org/10.1097/wco.0000000000000240
https://doi.org/10.1097/wco.0000000000000240
Autor:
Chi-Ting Su, Christine Jung, Branka Dabovic, Chih-Kang Chiang, Elaine C. Davis, Zsolt Urban, Jenq-Wen Huang, Suneeta Madan-Khetarpal, Elizabeth C. Lawrence, Kara L. Levine
Publikováno v:
Human Molecular Genetics. 24:4024-4036
Mutations in the gene for the latent transforming growth factor beta binding protein 4 (LTBP4) cause autosomal recessive cutis laxa type 1C. To understand the molecular disease mechanisms of this disease, we investigated the impact of LTBP4 loss on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ec226454b84c15b2b0deac4d47712c
https://doi.org/10.1093/hmg/ddv139
https://doi.org/10.1093/hmg/ddv139
Autor:
Krassimira Hadjiolova, Ralf Weiskirchen, Masahito Horiguchi, Vesna Todorovic, Daniel B. Rifkin
Publikováno v:
Matrix Biology. 43:61-70
Latent transforming growth factor-β binding protein-1 (LTBP-1) is an extracellular protein that is structurally similar to fibrillin and has an important role in controlling transforming growth factor-β (TGF-β) signaling by storing the cytokine in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf367db513d400e3abb23b26232ee74
https://doi.org/10.1016/j.matbio.2015.03.006
https://doi.org/10.1016/j.matbio.2015.03.006
Autor:
Qingmei Liu, Haiyan Chu, Shuai Jiang, Li Jin, Weilin Pu, Jiaying Lu, Lei Wang, Wenyu Wu, Jiucun Wang, Yanyun Ma, Xiangguang Shi, Wenzhen Tu, Weifeng Ding, Xiaodong Zhou
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 97(9)
Scleroderma is a fibrosis-related disorder characterized by cutaneous and internal organ fibrosis, and excessive collagen deposition in extracellular matrix (ECM) is a major cause of fibrosis. Transforming growth factor-β (TGF-β)/SMAD signaling has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b885f599d1d82280fea0cbcced83ef90
https://pubmed.ncbi.nlm.nih.gov/28263294
https://pubmed.ncbi.nlm.nih.gov/28263294
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND Latent transforming growth factor b binding protein 2 (LTBP2) is proven to be associated with ECM and involved in the advancement of several kinds of cancer. The present study evaluated the diagnosis and prognosis of pancreatic carcinoma (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56643767b981440c7eadee39f3aec0
https://pubmed.ncbi.nlm.nih.gov/28669978
https://pubmed.ncbi.nlm.nih.gov/28669978
Autor:
Lior Zilberberg, Ian B. Robertson, Branka Dabovic, Elaine C. Davis, Melinda Vassallo, Daniel B. Rifkin
Publikováno v:
Journal of Cellular Physiology. 230:226-236
Mice deficient in Latent TGFβ Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by genetically decreasing TGFβ2 levels. However, the elastic fiber assembly is not improved in Tgf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8923539a65d8144252a0d51b2a164c9f
https://doi.org/10.1002/jcp.24704
https://doi.org/10.1002/jcp.24704