Zobrazeno 1 - 10
of 798
pro vyhledávání: '"Late onset Alzheimer's disease"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Although research has indicated correlations between lipids, cerebrospinal fluid (CSF) metabolites, and Late-Onset Alzheimer’s Disease (LOAD), the specific causal relationships among these elements, as well as the roles and mech
Externí odkaz:
https://doaj.org/article/9f88f9d4d28f45c9bbcbc20a40011628
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract While there are currently over 40 replicated genes with mapped risk alleles for Late Onset Alzheimer’s disease (LOAD), the Apolipoprotein E locus E4 haplotype is still the biggest driver of risk, with odds ratios for neuropathologically co
Externí odkaz:
https://doaj.org/article/25d08a92396343cc9614e67ed0f7a585
Autor:
Bruce M. Cohen, Kai-Christian Sonntag
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105238- (2024)
Summary: Most cases of Alzheimer's disease (AD) are late-onset dementias (LOAD). However, research on AD is predominantly of early-onset disease (EOAD). The determinants of EOAD, gene variants of APP and presenilin proteins, are not the basic precurs
Externí odkaz:
https://doaj.org/article/eecd78567e01448aabb3b16a947759cc
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Background Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence rates and severity of progression. The cellular and molecular mechanisms underlying this cl
Externí odkaz:
https://doaj.org/article/5f87c211c83b406e9cc09480b9a10e80
Autor:
Mingri Zhao, Xun Chen, Jiangfeng Liu, Yanjin Feng, Chen Wang, Ting Xu, Wanxi Liu, Xionghao Liu, Mujun Liu, Deren Hou
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 7, Pp 1602-1607 (2024)
Sortilin-related receptor 1 (SORL1) is a critical gene associated with late-onset Alzheimer’s disease. SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport and metabolism of intracellul
Externí odkaz:
https://doaj.org/article/298eef30032f464cb23e68c4fc31773e
Autor:
Manash Sarma, Subarna Chatterjee
Publikováno v:
Diagnostics, Vol 14, Iss 23, p 2640 (2024)
Late-onset Alzheimer’s disease (LOAD) is a subtype of dementia that manifests after the age of 65. It is characterized by progressive impairments in cognitive functions, behavioral changes, and learning difficulties. Given the progressive nature of
Externí odkaz:
https://doaj.org/article/30807af634a64f6090272735cfb734f4
Autor:
Hui Hong, Yutong Chen, Weiran Liu, Xiao Luo, Minming Zhang, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract Introduction The distribution of voxel‐ and connection‐based white matter hyperintensity (WMH) patterns in early‐onset Alzheimer's disease (EOAD) and late‐onset Alzheimer's disease (LOAD), as well as factors associated with these pat
Externí odkaz:
https://doaj.org/article/eb6ed5c089d74f03876be398c13a83c6
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized. Genome-wide association studies (GWAS) have recently identified several candidate immune genes linked to d
Externí odkaz:
https://doaj.org/article/51b1d95115314980bae9c173450e4260
Autor:
Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Regen
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD). Whether changes in
Externí odkaz:
https://doaj.org/article/47525e9ee81a4be79e75de3d4e0675fa
Autor:
Julia Gamache, Daniel Gingerich, E. Keats Shwab, Julio Barrera, Melanie E. Garrett, Cordelia Hume, Gregory E. Crawford, Allison E. Ashley-Koch, Ornit Chiba-Falek
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-33 (2023)
Abstract Background The genetic underpinnings of late-onset Alzheimer’s disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain largely unknown. S
Externí odkaz:
https://doaj.org/article/9ea1075676284e67b77747fb17402708