Identification and experimental validation of druggable epigenetic targets in hepatoblastoma

Autor: Clavería-Cabello, Alex, Herranz, Jose Maria, Latasa, Maria Ujue, Arechederra, Maria, Uriarte, Iker, Pineda-Lucena, Antonio, Prosper, Felipe, Berraondo, Pedro, Alonso, Cristina, Sangro, Bruno, García Marin, Jose Juan, Martinez-Chantar, Maria Luz, Ciordia, Sergio, Corrales, Fernando José, Francalanci, Paola, Alaggio, Rita, Zucman-Rossi, Jessica, Indersie, Emilie, Cairo, Stefano, Domingo-Sàbat, Montserrat, Zanatto, Laura, Sancho-Bru, Pau, Armengol, Carolina, Berasain, Carmen, Fernandez-Barrena, Maite García, Avila, Matias Antonio

Publikováno v: In Journal of Hepatology October 2023 79(4):989-1005

Amphiregulin Induces the Alternative Splicing of p73 Into Its Oncogenic Isoform ΔEx2p73 in Human Hepatocellular Tumors

Autor: Castillo, Josefa, Goñi, Saioa, Latasa, María Ujue, Perugorría, María J., Calvo, Alicia, Muntané, Jordi, Bioulac–Sage, Paulette, Balabaud, Charles, Prieto, Jesús, Avila, Matías A., Berasain, Carmen

Publikováno v: In Gastroenterology 2009 137(5):1805-1815

Toll-like receptor-4 expression by hepatic progenitor cells and biliary epithelial cells in HCV-related chronic liver disease

Autor: Carotti, Simone, Vespasiani-Gentilucci, Umberto, Onetti-Muda, Andrea, Latasa, Maria Ujue, Avila, Matias A., Carpino, Guido, Picardi, Antonio, Morini, Sergio

Background. Toll-like receptor-4 (TLR4) is a transmembrane pattern recognition receptor that plays a key role in innate immunity by triggering inflammatory responses to Gram negative bacteria lipopolysaccharide (LPS) (1). Since liver is the main clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::243246d96b9f154277e65335989324fe

Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.

Autor: Chen C; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.; 12 de Octubre Health Research Institute (imas12), 28041 Madrid, Spain.; Department of General Surgery, Wuxi Branch of Zhongda Hospital, Southeast University, Wuxi 214105, China.; Department of Hepatic-Biliary-Pancreatic Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China., Wu H; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain., Ye H; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.; Department of Anesthesia, Zhongda Hospital, Southeast University, Nanjing 210008, China., Tortajada A; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.; 12 de Octubre Health Research Institute (imas12), 28041 Madrid, Spain., Rodríguez-Perales S; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain., Torres-Ruiz R; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain., Vidal A; Laboratorio de Investigación Traslacional (LRT1)-ProCURE, Institut Català d'Oncologia (ICO)-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain., Peligros MI; Institute of Pathology, Hospital Universitario Gregorio Marañon, 28007 Madrid, Spain., Reissing J; Department of Internal Medicine III, University Hospital RWTH, 52074 Aachen, Germany., Bruns T; Department of Internal Medicine III, University Hospital RWTH, 52074 Aachen, Germany., Mohamed MR; Department of Internal Medicine III, University Hospital RWTH, 52074 Aachen, Germany., Zheng K; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain., Lujambio A; Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Iraburu MJ; Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain., Colyn L; Hepatology Program, Cima, University of Navarra, 31008 Pamplona, Spain., Latasa MU; Hepatology Program, Cima, University of Navarra, 31008 Pamplona, Spain., Arechederra M; Hepatology Program, Cima, University of Navarra, 31008 Pamplona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Sanitarias de Navarra-IdiSNA, 31008 Pamplona, Spain., Fernández-Barrena MG; Hepatology Program, Cima, University of Navarra, 31008 Pamplona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Sanitarias de Navarra-IdiSNA, 31008 Pamplona, Spain., Berasain C; Hepatology Program, Cima, University of Navarra, 31008 Pamplona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Sanitarias de Navarra-IdiSNA, 31008 Pamplona, Spain., Vaquero J; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain.; Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Bañares R; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain.; Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Nelson LJ; Institute for Bioengineering (IBioE), Faraday Building, The University of Edinburgh, Edinburgh EH8 9AB, UK., Trautwein C; Department of Internal Medicine III, University Hospital RWTH, 52074 Aachen, Germany., Davis RJ; Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA., Martinez-Naves E; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.; 12 de Octubre Health Research Institute (imas12), 28041 Madrid, Spain., Nevzorova YA; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.; Department of Internal Medicine III, University Hospital RWTH, 52074 Aachen, Germany.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain., Villanueva A; Laboratorio de Investigación Traslacional (LRT1)-ProCURE, Institut Català d'Oncologia (ICO)-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain., Avila MA; Hepatology Program, Cima, University of Navarra, 31008 Pamplona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Sanitarias de Navarra-IdiSNA, 31008 Pamplona, Spain., Cubero FJ; Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, Spain.

Publikováno v: Cancers [Cancers (Basel)] 2021 Dec 24; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 24.