Interindividual differences contribute to variation in microbiota composition more than hormonal status: A prospective study

Autor: Zuzana Jackova, Jan J. Stepan, Stepan Coufal, Martin Kostovcik, Natalie Galanova, Zuzana Reiss, Karel Pavelka, Laszlo Wenchich, Hana Hruskova, Miloslav Kverka

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

AimsOvarian hormone deficiency is one of the main risk factors for osteoporosis and bone fractures in women, and these risks can be mitigated by menopausal hormone therapy. Recent evidence suggests that gut microbiota may link changes in estrogen lev

Externí odkaz: https://doaj.org/article/87b036fb08f74ff3ad05c7428b452402

Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder

Autor: Hana Hansikova, Eva Kitzlerová, Jiří Zeman, Jana Hroudová, Roman Jirák, Jiří Raboch, Zdeněk Fišar, Martina Zvěřová, Laszlo Wenchich, Jana Křížová

Publikováno v: Mitochondrion. 48:67-77

We analyzed activities of complex I, II, III, and IV, and citrate synthase (CS) in patients with major depressive disorder (MDD) or Alzheimer's disease (AD) presenting with or without depression. Associations of these parameters with disease or disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32507f0a2d7e81b42db45c23cb8d20f3
https://doi.org/10.1016/j.mito.2019.07.013

The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome

Autor: Jana, Ježková, Viktória, Ďurovcová, Laszlo, Wenchich, Hana, Hansíková, Jiří, Zeman, Václav, Hána, Josef, Marek, Zdeňka, Lacinová, Martin, Haluzík, Michal, Kršek

Publikováno v: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Purpose Cushing’s syndrome is characterized by metabolic disturbances including insulin resistance. Mitochondrial dysfunction is one pathogenic factor in the development of insulin resistance in patients with obesity. We explored whether mitochondr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c14f925eccf4989baa61097fc78cb75
https://pubmed.ncbi.nlm.nih.gov/31695455

YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

Autor: Jiri Zeman, Daniela Fornuskova, Kamila Vinsova, Lukas Stiburek, Laszlo Wenchich, Olga Kostkova, Josef Houstek, Jana Cesnekova

Publikováno v: Molecular Biology of the Cell

Loss-of-function studies show that the human mitochondrial YME1L protease ensures cell proliferation, maintains normal cristae morphology and complex I activity, acts in an antiapoptotic manner, protects mitochondria from accumulation of oxidatively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fd59161f0245227f0a9e480c0e8c0f
https://doi.org/10.1091/mbc.e11-08-0674

The impact of mitochondrial tRNA mutations on the amount of ATP synthase differs in the brain compared to other tissues

Autor: Hana Hansikova, Tomas Honzik, Lukas Stiburek, Marketa Tesarova, Laszlo Wenchich, Evzenie Tietzeova, Olga Brantova, Daniela Fornuskova, Jiri Zeman

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2008, 1782 (5), pp.317. ⟨10.1016/j.bbadis.2008.02.001⟩

The impact of point mutations in mitochondrial tRNA genes on the amount and stability of respiratory chain complexes and ATP synthase (OXPHOS) has been broadly characterized in cultured skin fibroblasts, skeletal muscle samples, and mitochondrial cyb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec4c604c6a1bb653f920be1b23217b5
https://doi.org/10.1016/j.bbadis.2008.02.001