Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Laszlo Nadasdi"'
Publikováno v:
International Journal of Peptide and Protein Research. 21:344-351
Four analogs of enkephalin (EK) have been synthesized by the solid-phase method and their biological activities have also been investigated. All four analogs were less active than Met-enkephalin (Met-EK) as shown by relative potencies in the guinea p
Autor:
Sinnei Kim, J. Ramachandran, Govindan Dayanithi, Ramasharma Kristipati, Gang Wang, Laszlo Nadasdi, Dennis Hom, Jean J. Nordmann, Edward L. Stuenkel, Robert Newcomb, José R. Lemos
Publikováno v:
The Journal of Physiology. 502:351-363
1 The nerve endings of rat neurohypophyses were acutely dissociated and a combination of pharmacological, biophysical and biochemical techniques was used to determine which classes of Ca2+ channels on these central nervous system (CNS) terminals cont
Autor:
S. Scott Bowersox, Zofia Zukowska-Grojec, Tejinder Singh, Laszlo Nadasdi, Karen L. Valentino, Brian B. Hoffman
Publikováno v:
Journal of Cardiovascular Pharmacology. 20:756-764
We examined the effects of omega-conopeptides, a novel class of neuronal voltage-gated calcium channel antagonists, on hemodynamic responses in rats. Intravenous (i.v.) injections of SNX-111 (omega-conopeptide MVIIA) dose-dependently decreased arteri
Autor:
William R. Gray, George P. Miljanich, Ramachandran J, Hammerland Lg, Doju Yoshikami, Laszlo Nadasdi, Ramilo Ca, Baldomero M. Olivera, Zafaralla Gc, Kristipati R
Publikováno v:
Biochemistry. 31:9919-9926
Three neurotoxic peptides from the venom of Conus striatus have been purified, biochemically characterized, and chemically synthesized. One of these, an acetylcholine receptor blocker designated alpha-conotoxin SII, has the sequence GCCCNPACGPNYGCGTS
Autor:
J. Michael McIntosh, George P. Miljanich, Bruce P. Bean, Virginia D. Monje, Aryan Azimi-Zoonooz, Baldomero M. Olivera, Lourdes J. Cruz, Isabelle M. Mintz, Laszlo Nadasdi, David R. Hillyard, Julita S. Imperial, J. Ramachandran
Publikováno v:
Neuron. 9:69-77
Voltage-sensitive Ca2+ channels that control neurotransmitter release are blocked by omega-conotoxin (omega-CgTx) GVIA from the marine snail Conus geographus, the most widely used inhibitor of neurotransmitter release. However, many mammalian synapse
Publikováno v:
Biochemistry. 29:8713-8719
The solution properties and bilayer association of two synthetic 30 amino acid peptides, GALA and LAGA, have been investigated at pH 5 and 7.5. These peptides have the same amino acid composition and differ only in the positioning of glutamic acid an
Autor:
Mohan Philip, Laszlo Nadasdi, Graham M. Smith, J. Ramachandran, Sadaaki Maeda, Ric I. Cone, Maithe Corbani, Wolfgang Sadee, Jelveh Lameh
Publikováno v:
Pharmaceutical Research. :1213-1221
The G protein coupled receptors (GPC-Rs) comprise a large superfamily of genes encoding numerous receptors which all show common structural features, e.g., seven putative membrane spanning domains. Their biological functions are extremely diverse, ra
Autor:
Roman Urfer, Laszlo Nadasdi, Arnold Ow, David S. Wexler, Francisco Anderson, Liping Gao, Alanna McAlorum, Shu-Gui Huang
Publikováno v:
Journal of biomolecular screening. 10(4)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally as- sayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption pr
Autor:
Thomas J. Abbruscato, Laszlo Nadasdi, George P. Miljanich, Thomas P. Davis, Robert Newcomb, Tej Singh
Publikováno v:
Peptides. 21(4)
Ziconotide is a selective peptide antagonist of the N-type calcium channel currently in clinical trials for analgesia. Ziconotide reached a maximal brain concentration of between 0.003 and 0.006% of the injected material per gram of tissue at 3–20
Autor:
Andrew Palma, Katalin Tarczy-Hornoch, Balazs G. Szoke, Cong Ruth, James A. Miller, Gang Wang, David J. Dooley, Joseph A. Loo, George P. Miljanich, Robert Newcomb, Laszlo Urge, Xiao-hua Chen, William F. Hopkins, Richard W. Tsien, Laszlo Nadasdi, José R. Lemos
Publikováno v:
Biochemistry. 37(44)
We describe the first potent and selective blocker of the class E Ca2+channel. SNX-482, a novel 41 amino acid peptide present in the venom of the African tarantula, Hysterocrates gigas, was identified through its ability to inhibit human class E Ca2+