Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Laszlo Homolya"'
Autor:
Daniel Becsky, Kitti Szabo, Szuzina Gyulai-Nagy, Tamas Gajdos, Zsuzsa Bartos, Arpad Balind, Laszlo Dux, Peter Horvath, Miklos Erdelyi, Laszlo Homolya, Aniko Keller-Pinter
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Efficient cell migration requires cellular polarization, which is characterized by the formation of leading and trailing edges, appropriate positioning of the nucleus and reorientation of the Golgi apparatus and centrosomes toward the leading edge. M
Externí odkaz:
https://doaj.org/article/373fa0078ea845a5a1af0e70b030a4d7
Autor:
Bálint Jezsó, Sára Kálmán, Kiara Gitta Farkas, Edit Hathy, Katalin Vincze, Dzsenifer Kovács-Schoblocher, Julianna Lilienberg, Csongor Tordai, Zsófia Nemoda, László Homolya, Ágota Apáti, János M. Réthelyi
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 688 (2024)
Background: Induced pluripotent stem cell (iPSC) based neuronal differentiation is valuable for studying neuropsychiatric disorders and pharmacological mechanisms at the cellular level. We aimed to examine the effects of typical and atypical antipsyc
Externí odkaz:
https://doaj.org/article/3e981b6cc32b43c692ca79eacd6a001e
Autor:
Orsolya Mózner, Boglárka Zámbó, Zsuzsa Bartos, Anna Gergely, Kata Sára Szabó, Bálint Jezsó, Ágnes Telbisz, György Várady, László Homolya, Tamás Hegedűs, Balázs Sarkadi
Publikováno v:
Membranes, Vol 13, Iss 10, p 822 (2023)
The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, r
Externí odkaz:
https://doaj.org/article/d2e751a0cf98473c95d382c7980d6546
Autor:
Zsuzsanna Gyöngy, Gábor Mocsár, Éva Hegedűs, Thomas Stockner, Zsuzsanna Ritter, László Homolya, Anita Schamberger, Tamás I Orbán, Judit Remenyik, Gergely Szakacs, Katalin Goda
Publikováno v:
eLife, Vol 12 (2023)
ABCG2 is an exporter-type ABC protein that can expel numerous chemically unrelated xeno- and endobiotics from cells. When expressed in tumor cells or tumor stem cells, ABCG2 confers multidrug resistance, contributing to the failure of chemotherapy. M
Externí odkaz:
https://doaj.org/article/ec20c8b08529401da60b87c02b59cc6f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Microglia, the primary immune cells of the brain, significantly influence the fate of neurons after neural damage. Depending on the local environment, they exhibit a wide range of phenotypes, including patrolling (naïve), proinflammatory, and anti-i
Externí odkaz:
https://doaj.org/article/51edf91c7d484bc58a643f06f51bab9f
Autor:
Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy, Mária Judit Molnár, László Homolya, Zsófia Nemoda, Ágota Apáti, János M. Réthelyi
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract Background De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased community functionin
Externí odkaz:
https://doaj.org/article/0aa0cb71e7ad4e1da3db707edcd65bb5
Autor:
Julianna Lilienberg, Zoltán Hegyi, Eszter Szabó, Edit Hathy, András Málnási-Csizmadia, János M. Réthelyi, Ágota Apáti, László Homolya
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Studies on neural development and neuronal regeneration after injury are mainly based on animal models. The establishment of pluripotent stem cell (PSC) technology, however, opened new perspectives for better understanding these processes in human mo
Externí odkaz:
https://doaj.org/article/907711e1ead44d3db302466c145f87d3
Autor:
Edit Hathy, Eszter Szabó, Katalin Vincze, Irén Haltrich, Eszter Kiss, Nóra Varga, Zsuzsa Erdei, György Várady, László Homolya, Ágota Apáti, János M. Réthelyi
Publikováno v:
Stem Cell Research, Vol 51, Iss , Pp 102140- (2021)
Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father - of a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified in th
Externí odkaz:
https://doaj.org/article/94b017b3777a4792b2e62e76d42e3eb8
Autor:
Réka Á. Kovács, Henrietta Vadászi, Éva Bulyáki, György Török, Vilmos Tóth, Dominik Mátyás, Judit Kun, Éva Hunyadi-Gulyás, Flóra Zsófia Fedor, Ádám Csincsi, Katalin Medzihradszky, László Homolya, Gábor Juhász, Katalin A. Kékesi, Mihály Józsi, Balázs A. Györffy, József Kardos
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Elements of the immune system particularly that of innate immunity, play important roles beyond their traditional tasks in host defense, including manifold roles in the nervous system. Complement-mediated synaptic pruning is essential in the developi
Externí odkaz:
https://doaj.org/article/12d1fdba2386404f82642af19df9eb00
Autor:
Zsuzsa Bartos, László Homolya
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Proper targeting of the urate and xenobiotic transporter ATP-binding transporter subfamily G member 2 (ABCG2) to the plasma membrane (PM) is essential for its normal function. The naturally occurring Q141K and M71V polymorphisms in ABCG2, associated
Externí odkaz:
https://doaj.org/article/97652a90bccc488c9e9abecf0fcc52ae