Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Laszlo Hackler"'
Autor:
Shannath L Merbs, Miriam A Khan, Laszlo Hackler, Verity F Oliver, Jun Wan, Jiang Qian, Donald J Zack
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32602 (2012)
Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other forms of tissue-specific gene regulation. We sought to explore the possible role of epigenetic
Externí odkaz:
https://doaj.org/article/4ee05b225d844f81a1125f290f1c1105
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46521 (2012)
Understanding gene regulation is crucial to dissect the molecular basis of human development and disease. Previous studies on transcription regulatory networks often focused on their static properties. Here we used retinal development as a model syst
Externí odkaz:
https://doaj.org/article/c3fcba613b76477086ba5086aee603c8
Autor:
Enikő Szabó, Szabolcs Modok, Benedek Rónaszéki, Anna Faragó, Nikolett Gémes, Lajos I. Nagy, László Hackler, Katalin Farkas, Patrícia Neuperger, József Á. Balog, Attila Balog, László G. Puskás, Gabor J. Szebeni
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundVaccination has proven the potential to control the COVID-19 pandemic worldwide. Although recent evidence suggests a poor humoral response against SARS-CoV-2 in vaccinated hematological disease (HD) patients, data on vaccination in these pa
Externí odkaz:
https://doaj.org/article/70d9f571fefd4dca894e4d98dc1c9c62
Autor:
Tomohiro Masuda, Donald J. Zack, Jiang Qian, Jun Wan, Laszlo Hackler, Shannath L. Merbs, Kieron Torres
Publikováno v:
Nucleic Acids Research
Alternative processing of pre-mRNA plays an important role in protein diversity and biological function. Previous studies on alternative splicing (AS) often focused on the spatial patterns of protein isoforms across different tissues. Here we studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac969a40ef802662d642d2432c5566d
https://doi.org/10.1093/nar/gkr545
https://doi.org/10.1093/nar/gkr545
Publikováno v:
Bioinformatics. 26:2289-2297
Motivation: The vertebrate retina is a complex neuronal tissue, and its development, normal functioning and response to injury and disease is subject to a variety of genetic factors. To understand better the regulatory and functional relationships be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfb5d40b04e7240af1f39dd6f531e79
https://doi.org/10.1093/bioinformatics/btq408
https://doi.org/10.1093/bioinformatics/btq408
Autor:
Noriko Esumi, Peter A. Campochiaro, Tomohiro Masuda, Shu Kachi, Donald J. Zack, Zhiyong Yang, Laszlo Hackler
Publikováno v:
Human Molecular Genetics. 18:128-141
A number of genes preferentially expressed in the retinal pigment epithelium (RPE) are associated with retinal degenerative disease. One of these, BEST1, encodes bestrophin-1, a protein that when mutated causes Best macular dystrophy. As a model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ca0aa8cf6568b01dd8e826e8361027
https://doi.org/10.1093/hmg/ddn323
https://doi.org/10.1093/hmg/ddn323
Autor:
Derek S. Welsbie, Zhiyong Yang, Yan Ge, Katherine L. Mitchell, Xinrong Zhou, Scott E. Martin, Cynthia A. Berlinicke, Laszlo Hackler, John Fuller, Jie Fu, Li-hui Cao, Bing Han, Douglas Auld, Tian Xue, Syu-ichi Hirai, Lucie Germain, Caroline Simard-Bisson, Richard Blouin, Judy V. Nguyen, Chung-ha O. Davis, Raymond A. Enke, Sanford L. Boye, Shannath L. Merbs, Nicholas Marsh-Armstrong, William W. Hauswirth, Aaron DiAntonio, Robert W. Nickells, James Inglese, Justin Hanes, King-Wai Yau, Harry A. Quigley, Donald J. Zack
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(10)
Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the pathways mediating RGC death and identify targets for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c386d3648f9ff405c5518158b256e3
https://pubmed.ncbi.nlm.nih.gov/23431148
https://pubmed.ncbi.nlm.nih.gov/23431148
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e46521 (2012)
PLoS ONE, Vol 7, Iss 10, p e46521 (2012)
Understanding gene regulation is crucial to dissect the molecular basis of human development and disease. Previous studies on transcription regulatory networks often focused on their static properties. Here we used retinal development as a model syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d548554c49408dc063632408b9ef99
https://pubmed.ncbi.nlm.nih.gov/23056331
https://pubmed.ncbi.nlm.nih.gov/23056331
Autor:
Verity F. Oliver, Laszlo Hackler, Jiang Qian, Miriam A. Khan, Shannath L. Merbs, Donald J. Zack, Jun Wan
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32602 (2012)
PLoS ONE
PLoS ONE
Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other forms of tissue-specific gene regulation. We sought to explore the possible role of epigenetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ee494e65a6d73cce80ed9354a02356
http://europepmc.org/articles/PMC3293830?pdf=render
http://europepmc.org/articles/PMC3293830?pdf=render
Autor:
Stacey Hose, Geetha Parthasarathy, Donald J. Zack, Laszlo Hackler, Yuri V. Sergeev, Debasish Sinha, Rhonda Grebe, Souvonik Adhya, Gerard A. Lutty, Cheng Zhang, Gitanjali Sehrawat, Walid Barbour, J. Samuel Zigler, James T. Handa, D. Scott McLeod, Imran Ahmed Bhutto
Publikováno v:
Journal of cell science. 124(Pt 4)
Phagocytosis of the shed outer segment discs of photoreceptors is a major function of the retinal pigmented epithelium (RPE). We demonstrate for the first time that βA3/A1-crystallin, a major structural protein of the ocular lens, is expressed in RP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8789aa9318164c42696776b868cde3d0
https://pubmed.ncbi.nlm.nih.gov/21266465
https://pubmed.ncbi.nlm.nih.gov/21266465