Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Laszlo G. Harsing"'
Autor:
Michael Spedding, Claude Sebban, Thérèse M. Jay, Cyril Rocher, Brigitte Tesolin-Decros, Paul Chazot, Esther Schenker, Gabor Szénási, György I. Lévay, Katalin Megyeri, Jozsef Barkóczy, Laszlo G. Hársing, Ian Thomson, Mark O. Cunningham, Miles A. Whittington, Lori-An Etherington, Jeremy J. Lambert, Ferenc A. Antoni, Istvan Gacsályi
Publikováno v:
Cells, Vol 11, Iss 7, p 1181 (2022)
Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal s
Externí odkaz:
https://doaj.org/article/a9ff5b5911fe463bbd0919d101083673
Autor:
Anna Rita Galambos, Zsolt Tamás Papp, Imre Boldizsár, Ferenc Zádor, László Köles, Laszlo G. Harsing, Mahmoud Al-Khrasani
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 421 (2024)
The development of opioid tolerance in patients on long-term opioid analgesic treatment is an unsolved matter in clinical practice thus far. Dose escalation is required to restore analgesic efficacy, but at the price of side effects. Intensive resear
Externí odkaz:
https://doaj.org/article/340e9968d2654450bd70518422b0e2f5
Striking Neurochemical and Behavioral Differences in the Mode of Action of Selegiline and Rasagiline
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13334 (2023)
Selegiline and rasagiline are two selective monoamine oxidase B (MAO-B) inhibitors used in the treatment of Parkinson’s disease. In their clinical application, however, differences in L-dopa-sparing potencies have been observed. The aim of this stu
Externí odkaz:
https://doaj.org/article/c01277dc8d83403b850b9b217cae3c5f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8543 (2022)
The trace amine-associated receptor 1 (TAAR1) is a Gs protein-coupled, intracellularly located metabotropic receptor. Trace and classic amines, amphetamines, act as agonists on TAAR1; they activate downstream signal transduction influencing neurotran
Externí odkaz:
https://doaj.org/article/7270c0a5bc2b4d57a542d615a5def665
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6209 (2021)
Neurodegenerative–neuroinflammatory disorders of the retina seriously hamper human vision. In searching for key factors that contribute to the development of these pathologies, we considered potential interactions among purinergic neuromodulation,
Externí odkaz:
https://doaj.org/article/b41105c9471e48a9866e1fffe31d7b58
Autor:
Amir Mohammadzadeh, Péter P. Lakatos, Mihály Balogh, Ferenc Zádor, Dávid Árpád Karádi, Zoltán S. Zádori, Kornél Király, Anna Rita Galambos, Szilvia Barsi, Pál Riba, Sándor Benyhe, László Köles, Tamás Tábi, Éva Szökő, Laszlo G. Harsing, Mahmoud Al-Khrasani
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2479 (2021)
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding
Externí odkaz:
https://doaj.org/article/78ce24478dcd4e6eb0152d1b4bcae416
Autor:
Laszlo G. Harsing, Marcell Harhai
Publikováno v:
Current Psychiatry Research and Reviews. 18:17-35
Abstract: Being a historical issue that withstands multiple societal control measures, alcohol abuse remains a major healthcare problem. Despite worldwide efforts to limit consumption and educate people about its effects, consumption rates remain unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8d9622a6e9d8c5235bad64e1f45940
https://doi.org/10.2174/2666082218666220126111415
https://doi.org/10.2174/2666082218666220126111415
Autor:
Dezső Schuler, Kornélia Baghy, Péter Ferdinandy, J. Knoll, Peter Hauser, Laszlo G. Harsing, Ildikó Miklya, Zsolt Mervai, Zsuzsa Schaff, S. Eckhardt, Tímea Pócza, Miklós Garami
Publikováno v:
Life Sciences. 182:57-64
First proof to show that (-)-deprenyl/selegiline (DEP), the first selective inhibitor of MAO-B, later identified as the first β-phenylethylamine (PEA)-derived synthetic catecholaminergic activity enhancer (CAE) substance and (2R)-1-(1-benzofuran-2-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeda1f03b77ab8b8bf5da8837a4026b
https://doi.org/10.1016/j.lfs.2017.06.010
https://doi.org/10.1016/j.lfs.2017.06.010
Autor:
Laszlo G. Harsing, Mahmoud Al-Khrasani, Szilvia Barsi, László Köles, Benjamin Hajnal, Kornél Király, Mihaly Balogh, Amir Mohammadzadeh, Zoltán S. Zádori
Publikováno v:
Brain research bulletin. 152
Interneurons operating with glycine neurotransmitter are involved in the regulation of pain transmission in the dorsal horn of the spinal cord. In addition to interneurons, glycine release also occurs from glial cells neighboring glutamatergic synaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d613bd3eea367352673914af598d01
https://pubmed.ncbi.nlm.nih.gov/31302238
https://pubmed.ncbi.nlm.nih.gov/31302238
Autor:
Gyula Simig, Adrienn Pálvölgyi, Szabolcs Kertesz, István Ling, Istvan Gacsalyi, Éva Szabó, Attila Gaál, Michael Spedding, Balázs Mihalik, Gábor Szénási, Delia Belelli, Gabor Gigler, Jeremy J. Lambert, Péter Kiricsi, Lori An Etherington, Balázs Volk, József Barkóczy, Katalin Pallagi, Ferenc A. Antoni, György Lévay, Gábor Kapus, Lilla Papp, Laszlo G. Harsing
Publikováno v:
European Journal of Pharmacology. 764:497-507
Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to produce compounds that potently inhibited the action of GABA on heterologously expressed GABAA receptors con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b449a320bd028d64481cb4dcfd24adf2
https://doi.org/10.1016/j.ejphar.2015.07.005
https://doi.org/10.1016/j.ejphar.2015.07.005