Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Laszlo G Ratkay"'
Autor:
Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb, Charles J. Cohen
Divalent metal transporter 1 (DMT1) cotransports ferrous iron and protons and is the primary mechanism for uptake of non-heme iron by enterocytes. Inhibitors are potentially useful as therapeutic agents to treat iron overload disorders such as heredi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a8fd089f5e95fb80b88ed63e8dd321
https://doi.org/10.1101/2022.09.01.506269
https://doi.org/10.1101/2022.09.01.506269
Autor:
Zaihui Zhang, Jing Zhong, Laszlo G. Ratkay, Jay Thompson, Jianmin Fu, Joseph Sanghara, Rainbow Kwan, Cadieux Jean-Jacques, Y. Paul Goldberg, Maryanne Mattice, Alison Brownlie-Cutts
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
Three distinct series of substituted pyrazole blockers of divalent metal transporter 1 (DMT1) were elaborated from the high-throughput screening pyrazolone hit 1. Preliminary hit-to-lead efforts revealed a preference for electron-withdrawing substitu