Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Laszlo Farkas"'
Autor:
Benjamin S. Johnson, Daniela Farkas, Rabab El-Mergawy, Jessica A. Adair, Ajit Elhance, Moemen Eltobgy, Francesca M. Coan, Lexie Chafin, Jessica A. Joseph, Alex Cornwell, Finny J. Johns, Lorena Rosas, Mauricio Rojas, Laszlo Farkas, Joseph S. Bednash, James D. Londino, Prabir Ray, Anuradha Ray, Valerian Kagan, Janet S. Lee, Bill B. Chen, Rama K. Mallampalli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacte
Externí odkaz:
https://doaj.org/article/2405260ebea942bc953a30e62d0266df
Autor:
Geoffrey Newcomb, Laszlo Farkas
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Our understanding of the pathophysiology of pulmonary arterial hypertension (PAH) has evolved over recent years, with the recognition that endothelial cell (EC) dysfunction and inflammation play an integral role in the development of this disease. EC
Externí odkaz:
https://doaj.org/article/5568f8214a794bf7bd6e77f5bc655d43
Autor:
Richard S. Nho, Cami Rice, Jayendra Prasad, Hannah Bone, Laszlo Farkas, Mauricio Rojas, Jeffrey C. Horowitz
Publikováno v:
Physiological Reports, Vol 11, Iss 17, Pp n/a-n/a (2023)
Abstract Hypoxia, a state of insufficient oxygen availability, promotes cellular lactate production. Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive scar formation, an
Externí odkaz:
https://doaj.org/article/5a709e79e4994df8a6a0a8536a2e0f4a
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Pulmonary arterial hypertension has characteristic changes to the mechanical environment, extracellular matrix, and cellular proliferation. In order to develop a culture system to investigate extracellular matrix (ECM) compositional-dependent changes
Externí odkaz:
https://doaj.org/article/1e28040facd343b99eeb3565e3c342c9
Autor:
Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A.A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105935- (2023)
Summary: Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypert
Externí odkaz:
https://doaj.org/article/8a31db23f5614a919e0d4eb917f3b10d
Autor:
Neil Blanchard, Patrick A. Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D. Cool, Rebecca L. Heise, Robert Freishtat, Laszlo Farkas
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Pulmonary arterial hypertension (PAH) is a progressive, devastating disease, and its main histological manifestation is an occlusive pulmonary arteriopathy. One important functional component of PAH is aberrant endothelial cell (EC) function
Externí odkaz:
https://doaj.org/article/7fa0178ec4104c688ee2af64722585df
Autor:
Laszlo Farkas, Elena A. Goncharova
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 14 (2022)
Externí odkaz:
https://doaj.org/article/b1a131ed576c4ed6a4a8b70dabf48afe
Autor:
Oscar Rosas Mejia, Erin S Gloag, Jianying Li, Marisa Ruane-Foster, Tiffany A Claeys, Daniela Farkas, Shu-Hua Wang, Laszlo Farkas, Gang Xin, Richard T Robinson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010093 (2022)
Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal respiratory infections, the effect of Mtb infection and its associated immu
Externí odkaz:
https://doaj.org/article/c925e85d769645df8dccdacf2959bf23
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Toll-like receptors serve a central role in innate immunity, but they can also modulate cell function in various non-immune cell types including endothelial cells. Endothelial cells are necessary for the organized function of the vascular system, and
Externí odkaz:
https://doaj.org/article/9cb272dfbdda4057baaa51ef3983055c
Autor:
Aneel R Bhagwani, Schuyler Hultman, Daniela Farkas, Rebecca Moncayo, Kaivalya Dandamudi, Arsema K Zadu, Carlyne D Cool, Laszlo Farkas
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213890 (2019)
Uncontrolled proliferation of endothelial cells is essential to the pathogenesis of pulmonary arterial hypertension (PAH). Both proliferation and cytoskeleton reorganization are associated with upregulation of the intermediate filament protein Nestin
Externí odkaz:
https://doaj.org/article/e8c8ed75ac6245148dd33db36adf9bfa