Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Laszlo Őrfi"'
Autor:
Judit Hodrea, Minh Ngoc Tran, Balazs Besztercei, Timea Medveczki, Attila J. Szabo, Laszlo Őrfi, Illes Kovacs, Andrea Fekete
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11646 (2023)
Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM
Externí odkaz:
https://doaj.org/article/2292488a7a7a4102a498b302429de4c8
Autor:
Csenge Szász, Domonkos Pap, Beáta Szebeni, Péter Bokrossy, László Őrfi, Attila J. Szabó, Ádám Vannay, Apor Veres-Székely
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17435 (2023)
Tissue fibrosis is characterized by chronic fibroblast activation and consequently excessive accumulation of collagen-rich extracellular matrix. In vitro microplate-based assays are essential to investigate the underlying mechanism and the effect of
Externí odkaz:
https://doaj.org/article/e2b699f041dc490d9d0937fdc22393ac
Autor:
János Garai, Marcell Krekó, László Őrfi, Péter Balázs Jakus, Zoltán Rumbus, Patrik Kéringer, András Garami, Eszter Vámos, Dominika Kovács, Viola Bagóné Vántus, Balázs Radnai, Tamás Lóránd
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1356-1368 (2021)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts a unique tautomerase enzymatic activity that has relevance concerning its multiple functions and its small molecule inhibitors ha
Externí odkaz:
https://doaj.org/article/99c9586e388a44fd96582e44a894d6e8
Autor:
Gábor Bögel, József Murányi, Bálint Szokol, Zoltán Kukor, István Móra, Tamás Kardon, László Őrfi, András Hrabák
Publikováno v:
Heliyon, Vol 8, Iss 1, Pp e08670- (2022)
JAK/STAT pathway plays a well-known role in macrophage polarization, but other signaling routes may also be involved. The aim of this study was to identify new signaling pathways and repolarize macrophages by selected protein kinase inhibitors. HL-60
Externí odkaz:
https://doaj.org/article/8d69a1286fd64981bb1ef2a7c567d0de
Autor:
Zoltán-István Szabó, György Orbán, Enikő Borbás, Dóra Csicsák, Szabina Kádár, Béla Fiser, Máté Dobó, Péter Horváth, Eszter Kiss, Lívia Budai, Judit Dobos, Tamás Pálla, László Őrfi, Gergely Völgyi, Gergő Tóth
Publikováno v:
Heliyon, Vol 7, Iss 7, Pp e07581- (2021)
Pomalidomide (POM), a potent anticancer thalidomide analogue was characterized in terms of cyclodextrin complexation to improve its aqueous solubility and maintain its anti-angiogenic activity. The most promising cyclodextrin derivatives were selecte
Externí odkaz:
https://doaj.org/article/1fba1d2d7e7d45489bb62fcd9fd8138f
Autor:
Apor Veres-Székely, Domonkos Pap, Beáta Szebeni, László Őrfi, Csenge Szász, Csenge Pajtók, Eszter Lévai, Attila J. Szabó, Ádám Vannay
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2119 (2022)
Fibroblasts play a central role in diseases associated with excessive deposition of extracellular matrix (ECM), including idiopathic pulmonary fibrosis. Investigation of different properties of fibroblasts, such as migration, proliferation, and colla
Externí odkaz:
https://doaj.org/article/d74f7a658b174325bfa4fce26dde57e6
Autor:
Gyula Bencze, Szilvia Bencze, Keith D. Rivera, James D. Watson, Mate Hidvegi, Laszlo Orfi, Nicholas K. Tonks, Darryl J. Pappin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c47f7a261d114bd4873160c6a67d63d1
Autor:
Johannes Brägelmann, Marcel A. Dammert, Felix Dietlein, Johannes M. Heuckmann, Axel Choidas, Stefanie Böhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A. French, Martin Peifer, H. Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C. Heukamp, Reinhard Büttner, Daniel Rauh, Bert M. Klebl, Roman K. Thomas, Martin L. Sos
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcin
Externí odkaz:
https://doaj.org/article/65260813004b4d5e8d198b9f59d2baa6
Autor:
Csilla Temesszentandrási-Ambrus, Szilárd Tóth, Rinkee Verma, Péter Bánhegyi, István Szabadkai, Ferenc Baska, Csaba Szántai-Kis, Ruben C Hartkoorn, Mary A Lingerfelt, Balázs Sarkadi, Gergely Szakács, László Őrfi, Valakunja Nagaraja, Sean Ekins, Ágnes Telbisz
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202749 (2018)
Drug resistant tuberculosis (TB) is a major worldwide health problem. In addition to the bacterial mechanisms, human drug transporters limiting the cellular accumulation and the pharmacological disposition of drugs also influence the efficacy of trea
Externí odkaz:
https://doaj.org/article/1a845305b8a4467da0d15ebe921cc693
Autor:
Robert Torka, Kinga Pénzes, Simone Gusenbauer, Christine Baumann, István Szabadkai, Lászlȯ Őrfi, György Kéri, Axel Ullrich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 4, Pp 301-318 (2014)
The Axl receptor tyrosine kinase (RTK) has been established as a strong candidate for targeted therapy of cancer. However, the benefits of targeted therapies are limited due to acquired resistance and activation of alternative RTKs. Therefore, we ask
Externí odkaz:
https://doaj.org/article/a3ed0e9a922e4bc19ad5113c9080010a