Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Laszlo, Otvos"'
Autor:
Laszlo Otvos, John D. Wade
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
A quarter of a century ago, designer peptide drugs finally broke through the glass ceiling. Despite the resistance by big pharma, biotechnology companies managed to develop injectable peptide-based drugs, first against orphan or other small volume di
Externí odkaz:
https://doaj.org/article/5be7682e79554e54836b767ca7cbfc50
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The antimicrobial peptide (AMP) ARV-1502 was designed based on naturally occurring short proline-rich AMPs, including pyrrhocoricin and drosocin. Identification of chaperone DnaK as a therapeutic target in Escherichia coli triggered intense research
Externí odkaz:
https://doaj.org/article/956eab2cc0d5433ab9bb234051d62ae7
Autor:
Lenise J. Kim, Mi-Kyung Shin, Huy Pho, Laszlo Otvos, Sergio Tufik, Monica L. Andersen, Luu V. Pham, Vsevolod Y. Polotsky
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundObesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure. Obe
Externí odkaz:
https://doaj.org/article/654bed9a103c4c73901704080baeaddc
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3150 (2022)
Proline-rich antimicrobial peptides (PrAMPs) are promising candidates to treat bacterial infections. The designer peptide ARV-1502 exhibits strong antimicrobial effects against Enterobacteriaceae both in vitro and in vivo. Since the inhibitory effect
Externí odkaz:
https://doaj.org/article/15926fa3ecf54cfb840a3abd84926e0c
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
The designer proline-rich antimicrobial peptide (PrAMP) Chex1-Arg20 amide (ARV-1502) is active against Gram-negative and Gram-positive pathogens in different murine infection models when administered parenterally and possesses a wide therapeutic inde
Externí odkaz:
https://doaj.org/article/048fff53e52c4bba99b93ac0c77da87d
Autor:
Roberta G. Marangoni, Yuri Masui, Feng Fang, Benjamin Korman, Gabriel Lord, Junghwa Lee, Katja Lakota, Jun Wei, Philipp E. Scherer, Laszlo Otvos, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki, Yoshihide Asano, Shinichi Sato, Warren G. Tourtellotte, John Varga
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Skin fibrosis in systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and reduced levels of circulating adiponectin. Since adiponectin has potent regulatory effects on fibroblasts, we sought to assess ad
Externí odkaz:
https://doaj.org/article/6f36cafe22ea4bf78193c98c31cf6636
Autor:
Laszlo Otvos
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic, and small molecule agonists of the adiponectin receptor. Peptide-based adiponec
Externí odkaz:
https://doaj.org/article/ff85c251891f492d881e534382fb3693
Autor:
Lenise J. Kim, Mi-Kyung Shin, Huy Pho, Laszlo Otvos, Sergio Tufik, Monica L. Andersen, Luu V. Pham, Vsevolod Y. Polotsky
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
BackgroundObesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure. Obe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baaceef947faae7cb6a892a0c012683
Autor:
Laszlo Otvos Jr., Eszter Ostorhazi, Dora Szabo, Steven D. Zumbrun, Lynda L. Miller, Stephanie A. Halasohoris, Puvi D. Desai, Sharon M. Int Veldt, Carl N. Kraus
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
As monotherapy, modified proline-rich antimicrobial peptides (PrAMPs) protect animals from experimental bacteremia in a dose-dependent manner. We evaluated the in vitro synergy of a modified PrAMP, A3-APO, a dimer, previously shown to inhibit the 70
Externí odkaz:
https://doaj.org/article/f79604ed68b04feeb322f7ee2debeb9b
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
The APO-type proline-arginine-rich host defense peptides exhibit potent in vitro killing parameters against Enterobacteriaceae but not to other bacteria. Because of the excellent in vivo properties against systemic and local infections, attempts are
Externí odkaz:
https://doaj.org/article/172f9adc4f0644b69b5bccce8843348d