Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lasti, Erfinanda"'
Autor:
Szandor Simmons, Erik Asmus, Weronika Karle, Markus Brack, Corey Wittig, Felix Behrens, Leander Reinshagen, Lasti Erfinanda, Laura Michalick, Patrick Smeele, Charissa van den Brom, Toralf Kaiser, Leif Sander, Ulf Landmesser, Arash Haghikia, Robert Preissner, Harm Bogaard, Martin Witzenrath, Wolfgang Kuebler, Robert Szulcek
Publikováno v:
Physiology. 38
Cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl- channel and ABC transporter; its mutations cause the clinical picture of cystic fibrosis (CF). Of late, CFTR has emerged as an important regulator of platelet function, as CFTR dysfu
Autor:
Erik Asmus, Weronika Karle, Markus C. Brack, Corey Wittig, Felix Behrens, Leander Reinshagen, Moritz Pfeiffer, Sabrina Schulz, Bertina Mandzimba-Maloko, Lasti Erfinanda, Paul L. Perret, Laura Michalick, Patrick J. Smeele, Endry H.T. Lim, Charissa E. van den Brom, Alexander B.A. Vonk, Toralf Kaiser, Norbert Suttorp, Stefan Hippenstiel, Leif E. Sander, Florian Kurth, Ursula Rauch, Ulf Landmesser, Arash Haghikia, Robert Preissner, Harm J. Bogaard, Martin Witzenrath, Wolfgang M. Kuebler, Robert Szulcek, Szandor Simmons
Publikováno v:
Asmus, E, Karle, W, Brack, M C, Wittig, C, Behrens, F, Reinshagen, L, Pfeiffer, M, Schulz, S, Mandzimba-Maloko, B, Erfinanda, L, Perret, P L, Michalick, L, Smeele, P J, Lim, E H T, van den Brom, C E, Vonk, A B A, Kaiser, T, Suttorp, N, Hippenstiel, S, Sander, L E, Kurth, F, Rauch, U, Landmesser, U, Haghikia, A, Preissner, R, Bogaard, H J, Witzenrath, M, Kuebler, W M, Szulcek, R & Simmons, S 2023, ' Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients ', The European respiratory journal, vol. 61, no. 3, 2202009 . https://doi.org/10.1183/13993003.02009-2022
European respiratory journal, 61(3). European Respiratory Society
The European respiratory journal, 61(3):2202009. European Respiratory Society
European respiratory journal, 61(3). European Respiratory Society
The European respiratory journal, 61(3):2202009. European Respiratory Society
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators reduce agonist-induced platelet activation and function. CFTR modulators, such as ivacaftor, present a promising therapeutic strategy in thrombocytopathies, including severe COVID-
Autor:
Lasti Erfinanda, Lin Zou, Birgitt Gutbier, Disi Lei, Katrin Reppe, Luiz Gustavo Teixeira Alves, Laura Kneller, Bill Schneider, Laura Michalick, Diana Fatykhova, Paul Schneider, Wolfgang Liedtke, Eisei Sohara, Timothy J. Mitchell, Andreas Hocke, Stefan Hippenstiel, Marcus A. Mall, Martin Witzenrath, Wolfgang M. Kuebler
Publikováno v:
The FASEB Journal. 36
Autor:
Tian, Jiang, Rudi, Samapati, Sergej, Klassen, Disi, Lei, Lasti, Erfinanda, Vera, Jankowski, Szandor, Simmons, Jun, Yin, Christoph, Arenz, Alexander, Dietrich, Thomas, Gudermann, Dieter, Adam, Michael, Schaefer, Joachim, Jankowski, Veit, Flockerzi, Rolf, Nüsing, Stefan, Uhlig, Wolfgang M, Kuebler
Publikováno v:
The European respiratory journal. 60(4)
Prostaglandin EIn isolated lungs, we measured increases in endothelial calcium (ΔCaPAF-induced ΔCaEP
Autor:
Anna Foryst-Ludwig, Arne Thiele, Laura M. Schreiber, Burkert Pieske, Lasti Erfinanda, Ulrich Kintscher, Wolfgang M. Kuebler, Jana Grune, Robert Klopfleisch, David Lohr, Niklas Beyhoff, Sarah Brix, Arata Tabuchi
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
Subendocardial damage is among the first cardiac manifestations of hypertension and is already present in asymptomatic disease states. Accordingly, markers of subendocardial impairment may f
Subendocardial damage is among the first cardiac manifestations of hypertension and is already present in asymptomatic disease states. Accordingly, markers of subendocardial impairment may f
Autor:
Tian Jiang, Rudi Samapati, Sergej Klassen, Disi Lei, Lasti Erfinanda, Vera Jankowski, Szandor Simmons, Jun Yin, Christoph Arenz, Alexander Dietrich, Thomas Gudermann, Dieter Adam, Michael Schaefer, Joachim Jankowski, Veit Flockerzi, Rolf Nüsing, Stefan Uhlig, Wolfgang M. Kuebler
Publikováno v:
European Respiratory Journal. 60:2102635
BackgroundProstaglandin E2(PGE2) increases pulmonary vascular permeability by activation of the PGE2receptor 3 (EP3), which may explain adverse pulmonary effects of the EP1/EP3receptor agonist sulprostone in patients. In addition, PGE2contributes to
Autor:
Krishnan Ravindran, Franziska Kohse, Lasti Erfinanda, Robert Preissner, Thomas Walther, Kathleen Gallo, Wolfgang M. Kuebler
Publikováno v:
The European respiratory journal. 57(1)
Epidemiological data from the SARS-CoV-2 outbreak suggest sex differences in mortality and vulnerability; however, sex-dependent incidence of acute respiratory distress syndrome (ARDS) remains controversial and the sex-dependent mechanisms of endothe
Autor:
Jasmin Lienau, Wolfgang Liedtke, Birgitt Gutbier, Martin Witzenrath, Zou Lin, Wolfgang M. Kuebler, Katrin Reppe, Lasti Erfinanda, Andreas C. Hocke
Publikováno v:
Acute Critical Care.
Rationale: Pneumonia is the most common cause of acute respiratory distress syndrome (ARDS). Cystic fibrosis transmembrane conductance regulator (CFTR) is downregulated in infectious and inflammatory conditions. Inhibition of CFTR was found increases
Autor:
Laura Michalick, Wolfgang Liedtke, Markus van der Giet, Wolfgang M. Kuebler, Ulrike Weichelt, Lasti Erfinanda
Publikováno v:
Anesthesiology. 126(2)
BackgroundMechanical ventilation can cause lung endothelial barrier failure and inflammation cumulating in ventilator-induced lung injury. Yet, underlying mechanotransduction mechanisms remain unclear. Here, the authors tested the hypothesis that act
Autor:
Jun Yin, Warren L. Lee, Wolfgang M. Kuebler, Wolfgang Liedtke, Lasti Erfinanda, Christine Tang, Laura Michalick, Arata Tabuchi, Geraldine Nouailles, Alexis Vogelzang, Haibo Zhang, Qinghong Dan, Liming Wang, Hermann Kuppe, Katalin Szászi, Andras Kapus, Lu Lv, Martin Witzenrath, Neil M. Goldenberg, Ingrid Fleming, Ori D. Rotstein, Khader Awwad
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
The cation channel transient receptor potential vanilloid (TRPV) 4 is expressed in endothelial and immune cells; however, its role in acute lung injury (ALI) is unclear. The functional relevance of TRPV4 was assessed in vivo, in isolated murine lungs