A microbial supply chain for production of the anti-cancer drug vinblastine.

Autor: Zhang J; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Hansen LG; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Gudich O; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Viehrig K; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Lassen LMM; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Schrübbers L; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Adhikari KB; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Rubaszka P; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Carrasquer-Alvarez E; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Chen L; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., D'Ambrosio V; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Lehka B; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Haidar AK; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Nallapareddy S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Giannakou K; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Laloux M; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Arsovska D; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Jørgensen MAK; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Chan LJG; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Kristensen M; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Christensen HB; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Sudarsan S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Stander EA; EA2106 Biomolecules and Plant Biotechnology, University of Tours, Tours, France., Baidoo E; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Petzold CJ; Joint BioEnergy Institute, Emeryville, CA, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Wulff T; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., O'Connor SE; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany., Courdavault V; EA2106 Biomolecules and Plant Biotechnology, University of Tours, Tours, France., Jensen MK; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark. mije@biosustain.dtu.dk., Keasling JD; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark. keasling@berkeley.edu.; Joint BioEnergy Institute, Emeryville, CA, USA. keasling@berkeley.edu.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. keasling@berkeley.edu.; Department of Chemical and Biomolecular Engineering, Department of Bioengineering, University of California, Berkeley, CA, USA. keasling@berkeley.edu.; Center for Synthetic Biochemistry, Institute for Synthetic Biology, Shenzhen Institutes of Advanced Technologies, Shenzhen, China. keasling@berkeley.edu.

Publikováno v: Nature [Nature] 2022 Sep; Vol. 609 (7926), pp. 341-347. Date of Electronic Publication: 2022 Aug 31.