Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lasse Tengbjerg Hansen"'
Autor:
Grant McArthur, Paul E.G. Kristjansen, Klaus Stensgaard Frederiksen, Dorthe Lundsgaard, Kresten Skak, Lasse Tengbjerg Hansen, Ulrik Mouritzen, Birte K. Skrumsager, Jonathan Cebon, Michael Millward, Richard F. Kefford, Ben Brady, Ian D. Davis
Purpose: Human interleukin-21 (IL-21) is a class I cytokine that mediates activation of CD8+ T cells, natural killer (NK) cells, and other cell types. We report final clinical and biological results of a phase II study of recombinant human IL-21 (rIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d697d62b9970cc19d254b96f83eeba4
https://doi.org/10.1158/1078-0432.c.6517471
https://doi.org/10.1158/1078-0432.c.6517471
Autor:
Grant McArthur, Paul E.G. Kristjansen, Klaus Stensgaard Frederiksen, Dorthe Lundsgaard, Kresten Skak, Lasse Tengbjerg Hansen, Ulrik Mouritzen, Birte K. Skrumsager, Jonathan Cebon, Michael Millward, Richard F. Kefford, Ben Brady, Ian D. Davis
Supplementary Figures S1-S3 from Clinical and Biological Efficacy of Recombinant Human Interleukin-21 in Patients with Stage IV Malignant Melanoma without Prior Treatment: A Phase IIa Trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cebdd282d68de54e04690086196625c
https://doi.org/10.1158/1078-0432.22440097.v1
https://doi.org/10.1158/1078-0432.22440097.v1
Autor:
Claus Storgaard Sørensen, Maxwell Sehested, Kasper Fugger, Fredrik Johansson, Jiri Bartek, Thomas Helleday, Jiri Lukas, Lasse Tengbjerg Hansen, Randi G. Syljuåsen, Cecilia Lundin
Publikováno v:
Karolinska Institutet
Human checkpoint kinase 1 (Chk1) is an essential kinase required to preserve genome stability. Here, we show that Chk1 inhibition by two distinct drugs, UCN-01 and CEP-3891, or by Chk1 small interfering RNA (siRNA) leads to phosphorylation of ATR tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e2468c3d7e8395ae77379a239ba1e1
https://doi.org/10.1128/mcb.25.9.3553-3562.2005
https://doi.org/10.1128/mcb.25.9.3553-3562.2005
Autor:
Nanna Junker, Julia S. Johansen, Paul E.G. Kristjansen, Lasse Tengbjerg Hansen, Eva Løbner Lund
Publikováno v:
Cancer Science. 96:183-190
YKL-40 is a 40 kDa secreted glycoprotein belonging to the family of 'mammalian chitinase-like proteins', but without chitinase activity. YKL-40 has a proliferative effect on fibroblasts, chondrocytes and synoviocytes, and chemotactic effect on endoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5366ac694749d11d24d213ea9f23b5
https://doi.org/10.1111/j.1349-7006.2005.00026.x
https://doi.org/10.1111/j.1349-7006.2005.00026.x
Autor:
Jaroslaw Dziegielewski, Randi G. Syljuåsen, Jiri Bartek, Claus Storgaard Sørensen, Cecilia Lundin, Thomas Helleday, Lasse Tengbjerg Hansen
Publikováno v:
Nature Cell Biology. 7:195-201
The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replication. However, it is unclear whether Chk1 is involved in the repair of damaged DNA. Here we establish that Chk1 is a key regulator of genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c470f23d522b57e7c48d6fe31610811
https://doi.org/10.1038/ncb1212
https://doi.org/10.1038/ncb1212
Autor:
T. Bocker Edmonston, C. Schmutte, L.J. Rasmussen, T. Thykjaer, L. Nørgård Petersen, Torben F. Ørntoft, Mogens Spang-Thomsen, Richard Fishel, P. Keller, Lasse Tengbjerg Hansen
Publikováno v:
European Journal of Cancer. 39:1456-1467
The role of mismatch repair (MMR) in small-cell lung cancer (SCLC) is controversial, as the phenotype of a MMR-deficiency, microsatellite instability (MSI), has been reported to range from 0 to 76%. We studied the MMR pathway in a panel of 21 SCLC ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9254e0bad2184ed632a3f3c08fac2da3
https://doi.org/10.1016/s0959-8049(03)00306-x
https://doi.org/10.1016/s0959-8049(03)00306-x
Autor:
Hans Skovgaard Poulsen, Thomas Helleday, Lone Petersen, Lasse Tengbjerg Hansen, Claus Storgaard Sørensen, Mogens Spang-Thomsen, Cecilia Lundin
Publikováno v:
University of Copenhagen
Two human small cell lung cancer (SCLC) subpopulations, CPH 54A, and CPH 54B, established from the same patient tumor by in vitro cloning, were investigated. The tumor was classified as intermediate-type SCLC. The cellular sensitivity to ionizing rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1d6b4b9bb3f3444fe1c4721cacd825
https://doi.org/10.1016/s0169-5002(03)00026-6
https://doi.org/10.1016/s0169-5002(03)00026-6
Publikováno v:
Cancer chemotherapy and pharmacology. 56(5)
We examined how the effect of topotecan is modulated by transient hypoxia in three different tumor lines, Lewis lung carcinoma (LLC), U87 human glioblastoma and DMS273 human small cell lung cancer. Four groups of tumor bearing mice were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8316a9cc9378c6202f82c32759b6ac09
https://pubmed.ncbi.nlm.nih.gov/15895231
https://pubmed.ncbi.nlm.nih.gov/15895231
Publikováno v:
International journal of cancer. 105(4)
Etoposide (VP16) is a potent inducer of DNA double-strand breaks (DSBs) and is efficiently used in small cell lung cancer (SCLC) therapy. However, acquired VP16 resistance remains an important barrier to effective treatment. To understand the underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a9c233c634a0cd4763867fe5268b48
https://pubmed.ncbi.nlm.nih.gov/12712436
https://pubmed.ncbi.nlm.nih.gov/12712436
Autor:
Niklas Schultz, Catherine Arnaudeau, Atul Mohindra, Thomas Helleday, Lasse Tengbjerg Hansen, Cecilia Lundin
Publikováno v:
Journal of molecular biology. 328(3)
The RAD51 protein, a eukaryotic homologue of the Escherichia coli RecA protein, plays an important role in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) in mammalian cells. Recent findings suggest that HR may be impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e8e22038640840a1e1116d8a15543f
https://pubmed.ncbi.nlm.nih.gov/12706714
https://pubmed.ncbi.nlm.nih.gov/12706714